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Journal of Neuroscience, Vol 16, 621-630, Copyright © 1996 by Society for Neuroscience
Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system
AJ MacLennan, EN Vinson, L Marks, DL McLaurin, M Pfeifer and N Lee
Department of Neuroscience, University of Florida Brain Institute, University of Florida College of Medicine, Gainesville 32610-0244, USA.
Ciliary neurotrophic factor receptor alpha (CNTFR alpha) is essential for
normal embryonic development and may be involved in postnatal and adult
neuronal maintenance. In addition, a rapidly growing body of evidence
suggests that CNTFR alpha serves as a site of action for future growth
factor therapeutics capable of treating a wide variety of disorders
resulting from neuronal loss. We raised two polyclonal, anti- CNTFR alpha
antisera against synthetic peptides corresponding to independent regions of
rat CNTFR alpha. Western blot and immunohistochemical analyses indicated
that affinity-purified preparations of both antisera specifically recognize
CNTFR alpha. In the adult brain, the highest levels of CNTFR alpha
immunoreactivity were found in the perikarya, dendrites and, occasionally,
the axons of several distinct classes of neurons including hippocampal
formation neurons, some sensory neurons, and many neurons involved in motor
control. CNTFR alpha immunoreactivity also was concentrated in the
following: perikarya, dendrites, and axons of ventral horn motor neurons in
adult spinal cord; perikarya and axons of adult dorsal root ganglion
neurons; and axons in adult peripheral nerve. In embryonic tissue, the
highest levels of CNTFR alpha immunoreactivity were observed in
differentiating neurons and their processes. Therefore, the present data
suggest that CNTFR alpha serves several diverse functions in adulthood and
during development.
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