 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 675-687, Copyright © 1996 by Society for Neuroscience
Brain-derived neurotrophic factor promotes the differentiation of various hippocampal nonpyramidal neurons, including Cajal-Retzius cells, in organotypic slice cultures
S Marty, P Carroll, A Cellerino, E Castren, V Staiger, H Thoenen and D Lindholm
Department of Neurochemistry, Max Planck Institute for Psychiatry, Martinsried, Germany.
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central
nervous system, where its function is poorly understood. The aim of this
study was to investigate the effects of BDNF on the differentiation of
hippocampal nonpyramidal neurons using organotypic slice cultures prepared
from postnatal rats. The application of BDNF induced an increase in
immunostaining for the microtubule-associated protein (MAP)-2 in
non-pyramidal neurons of the stratum oriens. BDNF promotes the elongation
of the dendrites of these neurons, as demonstrated by analysis after
biocytin labeling. Calbindin-D- and calretinin-containing subgroups of
nonpyramidal cells in the stratum oriens were responsive to BDNF but not to
nerve growth factor, as shown by an increase in the number of neurons
immunostained for these proteins. BDNF also induced an increase in
neuropeptide Y immunostaining of stratum oriens neurons. In contrast, BDNF
had no effect on parvalbumin immunostaining, despite the fact that these
cells express the BDNF receptor trkB. In addition, BDNF increased
calretinin immunoreactivity in Cajal-Retzius cells situated around the
hippocampal fissure. The Cajal-Retzius neurons persisted in slices beyond
the time at which they degenerate in vivo. However, BDNF is not required
for the survival of these cells, because they also persisted in slices from
BDNF knock-out mice. The present results indicate that BDNF exerts an
effect on the morphology of stratum oriens nonpyramidal cells and their
calcium-binding protein levels. BDNF also regulates the calretinin content
of Cajal-Retzius cells but is not necessary for their survival.
This article has been cited by other articles:
|
|
|
|
 
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Physiol Rev,
October 1, 2007;
87(4):
1215 - 1284.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Conrad
What Is the Functional Significance of Chronic Stress-Induced CA3 Dendritic Retraction Within the Hippocampus?
Behav Cogn Neurosci Rev,
March 1, 2006;
5(1):
41 - 60.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G. Gomez-Lira, M. Lamas, H. Romo-Parra, and R. Gutierrez
Programmed and Induced Phenotype of the Hippocampal Granule Cells
J. Neurosci.,
July 27, 2005;
25(30):
6939 - 6946.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Danzer and J. O. McNamara
Localization of Brain-Derived Neurotrophic Factor to Distinct Terminals of Mossy Fiber Axons Implies Regulation of Both Excitation and Feedforward Inhibition of CA3 Pyramidal Cells
J. Neurosci.,
December 15, 2004;
24(50):
11346 - 11355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Patz, J. Grabert, T. Gorba, M. J. Wirth, and P. Wahle
Parvalbumin Expression in Visual Cortical Interneurons Depends on Neuronal Activity and TrkB Ligands during an Early Period of Postnatal Development
Cereb Cortex,
March 1, 2004;
14(3):
342 - 351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Wirth, A. Brun, J. Grabert, S. Patz, and P. Wahle
Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5
Development,
December 1, 2003;
130(23):
5827 - 5838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Jin, H. Hu, P. H. Mathers, and A. Agmon
Brain-Derived Neurotrophic Factor Mediates Activity-Dependent Dendritic Growth in Nonpyramidal Neocortical Interneurons in Developing Organotypic Cultures
J. Neurosci.,
July 2, 2003;
23(13):
5662 - 5673.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Ghoumari, R. Wehrle, C. I. De Zeeuw, C. Sotelo, and I. Dusart
Inhibition of Protein Kinase C Prevents Purkinje Cell Death But Does Not Affect Axonal Regeneration
J. Neurosci.,
May 1, 2002;
22(9):
3531 - 3542.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. S. Pollock, E. Vernon, M. E. Forbes, Q. Yan, Y.-T. Ma, T. Hsieh, R. Robichon, D. O. Frost, and J. E. Johnson
Effects of Early Visual Experience and Diurnal Rhythms on BDNF mRNA and Protein Levels in the Visual System, Hippocampus, and Cerebellum
J. Neurosci.,
June 1, 2001;
21(11):
3923 - 3931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Shetty and D. A. Turner
Fetal Hippocampal Grafts Containing CA3 Cells Restore Host Hippocampal Glutamate Decarboxylase-Positive Interneuron Numbers in a Rat Model of Temporal Lobe Epilepsy
J. Neurosci.,
December 1, 2000;
20(23):
8788 - 8801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Marty, R. Wehrle, and C. Sotelo
Neuronal Activity and Brain-Derived Neurotrophic Factor Regulate the Density of Inhibitory Synapses in Organotypic Slice Cultures of Postnatal Hippocampus
J. Neurosci.,
November 1, 2000;
20(21):
8087 - 8095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. M. Bolton, A. J. Pittman, and D. C. Lo
Brain-Derived Neurotrophic Factor Differentially Regulates Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures
J. Neurosci.,
May 1, 2000;
20(9):
3221 - 3232.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Fawcett, M. A. Alonso-Vanegas, S. J. Morris, F. D. Miller, A. F. Sadikot, and R. A. Murphy
Evidence that Brain-Derived Neurotrophic Factor from Presynaptic Nerve Terminals Regulates the Phenotype of Calbindin-Containing Neurons in the Lateral Septum
J. Neurosci.,
January 1, 2000;
20(1):
274 - 282.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Frerking, R. C. Malenka, and R. A. Nicoll
Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus
J Neurophysiol,
December 1, 1998;
80(6):
3383 - 3386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Alcantara, M. Ruiz, G. D'Arcangelo, F. Ezan, L. de Lecea, T. Curran, C. Sotelo, and E. Soriano
Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse
J. Neurosci.,
October 1, 1998;
18(19):
7779 - 7799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cellerino, G. Pinzon-Duarte, P. Carroll, and K. Kohler
Brain-Derived Neurotrophic Factor Modulates the Development of the Dopaminergic Network in the Rodent Retina
J. Neurosci.,
May 1, 1998;
18(9):
3351 - 3362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Perez and D. B. Kelley
Androgen Mitigates Axotomy-Induced Decreases in Calbindin Expression in Motor Neurons
J. Neurosci.,
October 1, 1997;
17(19):
7396 - 7403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Paysan, A. Kossel, J. Bolz, and J.-M. Fritschy
Area-specific regulation of gamma -aminobutyric acid type A receptor subtypes by thalamic afferents in developing rat neocortex
PNAS,
June 24, 1997;
94(13):
6995 - 7000.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Rutherford, A. DeWan, H. M. Lauer, and G. G. Turrigiano
Brain-Derived Neurotrophic Factor Mediates the Activity-Dependent Regulation of Inhibition in Neocortical Cultures
J. Neurosci.,
June 15, 1997;
17(12):
4527 - 4535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Del Rio, B. Heimrich, H. Super, V. Borrell, M. Frotscher, and E. Soriano
Differential Survival of Cajal-Retzius Cells in Organotypic Cultures of Hippocampus and Neocortex
J. Neurosci.,
November 1, 1996;
16(21):
6896 - 6907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kang and E. M. Schuman
A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
Science,
September 6, 1996;
273(5280):
1402 - 1406.
[Abstract]
|
|
|
|
|
|
|
N. Rocamora, M. Pascual, L. Acsady, L. de Lecea, T. F. Freund, and E. Soriano
Expression of NGF and NT3 mRNAs in Hippocampal Interneurons Innervated by the GABAergic Septohippocampal Pathway
J. Neurosci.,
June 15, 1996;
16(12):
3991 - 4004.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
