 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 688-701, Copyright © 1996 by Society for Neuroscience
Identification and molecular characterization of Unc-33-like phosphoprotein (Ulip), a putative mammalian homolog of the axonal guidance-associated unc-33 gene product
T Byk, T Dobransky, C Cifuentes-Diaz and A Sobel
Institut National de la Sante et de la Recherche Medicale, Paris, France.
The control of neuritic extension and guidance is critical for the
development, maturation, and regeneration of functional neuronal circuits.
We identified a neuronal 64-85 kDa phosphoprotein, the expression of which
in mouse brain is regulated during development, reaching a peak at
approximately 5 d postnatal, when maturation of neurons and synaptic
connections is highly active. The amino acid sequence of the mouse protein
deduced from its cloned cDNA reveals similarities with that of the neuritic
outgrowth- and guidance-related product of the unc-33 gene in
Caenorhabditis elegans. The regulation of its phosphorylation in response
to nerve growth factor, as well as its localization in neurites and growth
cones and at the neuromuscular junction, further indicates that Ulip (for
Unc-33-like phosphoprotein) is not only a structural but likely is also a
functional mammalian homolog of Unc-33, potentially involved in the control
of neuritic outgrowth and axonal guidance.
This article has been cited by other articles:
|
|
|
|
 
L. Cnops, T.-T. Hu, K. Burnat, and L. Arckens
Influence of Binocular Competition on the Expression Profiles of CRMP2, CRMP4, Dyn I, and Syt I in Developing Cat Visual Cortex
Cereb Cortex,
May 1, 2008;
18(5):
1221 - 1231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Patrakitkomjorn, D. Kobayashi, T. Morikawa, M. M. Wilson, N. Tsubota, A. Irie, T. Ozawa, M. Aoki, N. Arimura, K. Kaibuchi, et al.
Neurofibromatosis Type 1 (NF1) Tumor Suppressor, Neurofibromin, Regulates the Neuronal Differentiation of PC12 Cells via Its Associating Protein, CRMP-2
J. Biol. Chem.,
April 4, 2008;
283(14):
9399 - 9413.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K.-Y. Su, W.-L. Chien, W.-M. Fu, I-S. Yu, H.-P. Huang, P.-H. Huang, S.-R. Lin, J.-Y. Shih, Y.-L. Lin, Y.-P. Hsueh, et al.
Mice Deficient in Collapsin Response Mediator Protein-1 Exhibit Impaired Long-Term Potentiation and Impaired Spatial Learning and Memory
J. Neurosci.,
March 7, 2007;
27(10):
2513 - 2524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Z. Alabed, M. Pool, S. O. Tone, and A. E. Fournier
Identification of CRMP4 as a Convergent Regulator of Axon Outgrowth Inhibition
J. Neurosci.,
February 14, 2007;
27(7):
1702 - 1711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Sato, K. Suzuki, H. Yamazaki, and S. Nakanishi
A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells
PNAS,
April 19, 2005;
102(16):
5874 - 5879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Uchida, T. Ohshima, Y. Sasaki, H. Suzuki, S. Yanai, N. Yamashita, F. Nakamura, K. Takei, Y. Ihara, K. Mikoshiba, et al.
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3{beta} phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease
Genes Cells,
February 1, 2005;
10(2):
165 - 179.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hotta, R. Inatome, J. Yuasa-Kawada, Q. Qin, H. Yamamura, and S. Yanagi
Critical Role of Collapsin Response Mediator Protein-associated Molecule CRAM for Filopodia and Growth Cone Development in Neurons
Mol. Biol. Cell,
January 1, 2005;
16(1):
32 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Genter, P. P. Van Veldhoven, A. G. Jegga, B. Sakthivel, S. Kong, K. Stanley, D. P. Witte, C. L. Ebert, and B. J. Aronow
Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system
Physiol Genomics,
December 16, 2003;
16(1):
67 - 81.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. C. Quinn, E. Chen, T. G. Kinjo, G. Kelly, A. W. Bell, R. C. Elliott, P. S. McPherson, and S. Hockfield
TUC-4b, a Novel TUC Family Variant, Regulates Neurite Outgrowth and Associates with Vesicles in the Growth Cone
J. Neurosci.,
April 1, 2003;
23(7):
2815 - 2823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Franken, U. Junghans, V. Rosslenbroich, S. L. Baader, R. Hoffmann, V. Gieselmann, C. Viebahn, and J. Kappler
Collapsin Response Mediator Proteins of Neonatal Rat Brain Interact with Chondroitin Sulfate
J. Biol. Chem.,
January 24, 2003;
278(5):
3241 - 3250.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Shih, S.-C. Yang, T.-M. Hong, A. Yuan, J. J. W. Chen, C.-J. Yu, Y.-L. Chang, Y.-C. Lee, K. Peck, C.-W. Wu, et al.
Collapsin Response Mediator Protein-1 and the Invasion and Metastasis of Cancer Cells
J Natl Cancer Inst,
September 19, 2001;
93(18):
1392 - 1400.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Yoshida, A. Watanabe, and Y. Ihara
Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer's Disease
J. Biol. Chem.,
April 17, 1998;
273(16):
9761 - 9768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Takahashi, F. Nakamura, and S. M. Strittmatter
Neuronal and Non-Neuronal Collapsin-1 Binding Sites in Developing Chick Are Distinct from Other Semaphorin Binding Sites
J. Neurosci.,
December 1, 1997;
17(23):
9183 - 9193.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Gaetano, T. Matsuo, and C. J. Thiele
Identification and Characterization of a Retinoic Acid-regulated Human Homologue of the unc-33-like Phosphoprotein Gene (hUlip) from Neuroblastoma Cells
J. Biol. Chem.,
May 2, 1997;
272(18):
12195 - 12201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-H. Wang and S. M. Strittmatter
A Family of Rat CRMP Genes Is Differentially Expressed in the Nervous System
J. Neurosci.,
October 1, 1996;
16(19):
6197 - 6207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Gu and Y. Ihara
Evidence That Collapsin Response Mediator Protein-2 Is Involved in the Dynamics of Microtubules
J. Biol. Chem.,
June 9, 2000;
275(24):
17917 - 17920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Matsuo, J. K. Stauffer, R. L. Walker, P. Meltzer, and C. J. Thiele
Structure and Promoter Analysis of the Human unc-33-like Phosphoprotein Gene. E-BOX REQUIRED FOR MAXIMAL EXPRESSION IN NEUROBLASTOMA AND MYOBLASTS
J. Biol. Chem.,
May 26, 2000;
275(22):
16560 - 16568.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Fukada, I. Watakabe, J. Yuasa-Kawada, H. Kawachi, A. Kuroiwa, Y. Matsuda, and M. Noda
Molecular Characterization of CRMP5, a Novel Member of the Collapsin Response Mediator Protein Family
J. Biol. Chem.,
November 22, 2000;
275(48):
37957 - 37965.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Inatome, T. Tsujimura, T. Hitomi, N. Mitsui, P. Hermann, S.'i. Kuroda, H. Yamamura, and S. Yanagi
Identification of CRAM, a Novel unc-33 Gene Family Protein That Associates with CRMP3 and Protein-tyrosine Kinase(s) in the Developing Rat Brain
J. Biol. Chem.,
August 25, 2000;
275(35):
27291 - 27302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
