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Journal of Neuroscience, Vol 16, 714-722, Copyright © 1996 by Society for Neuroscience
Modulation of dopamine efflux in the nucleus accumbens after cholinergic stimulation of the ventral tegmental area in intact, pedunculopontine tegmental nucleus-lesioned, and laterodorsal tegmental nucleus-lesioned rats
CD Blaha, LF Allen, S Das, WL Inglis, MP Latimer, SR Vincent and P Winn
Department of Psychology, University of British Columbia, Vancouver, Canada.
Microinjections of the cholinergic receptor agonist nicotine and the
cholinesterase inhibitor neostigmine were made into the ventral tegmental
area (VTA) of urethane-anesthetized rats, and dopamine (DA) efflux in the
nucleus accumbens was measured using in vivo chronoamperometry.
Dose-dependent increases in the chronoamperometric signals corresponding to
increased DA efflux were observed in the nucleus accumbens of normal intact
rats after cholinergic stimulation of the VTA. The source of the
cholinergic input to the VTA was investigated by making excitotoxic lesions
in either the laterodorsal tegmental nucleus (LDTg) or the pedunculopontine
tegmental nucleus (PPTg). Compared with sham-operated control animals,
which showed the same response as intact, nonlesioned rats, ibotenate
lesions of the LDTg attenuated the stimulatory effects of intra-VTA
neostigmine on DA efflux in the nucleus accumbens. In contrast, rats with
ibotenate lesions of the PPTg showed normal nucleus accumbens DA eflux
after intra-VTA injections of neostigmine. Such lesions in the PPTg
attenuate DA efflux in the caudate-putamen stimulated by injections of
neostigmine into the substantia nigra pars compacta (SNc). The present data
show that cholinergic neurons in the LDTg, but not the PPTg, regulate the
activity of DA-containing neurons in the VTA, which complements previous
data showing that cholinergic neurons in the PPTg regulate DA-containing
neurons in the SNc.
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