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Journal of Neuroscience, Vol 16, 853-860, Copyright © 1996 by Society for Neuroscience
Factors regulating the reversibility of long-term potentiation
U Stäubli and D Chun
Center for Neural Science, New York University, New York 10003, USA.
Theta burst stimulation (TBS) produces an extremely stable form of long-
term potentiation (LTP). In contrast, a brief episode of single-pulse
stimulation at theta frequency [theta pulse stimulation (TPS)] has been
demonstrated to reverse LTP in area CA1 of slices and freely moving animals
without causing depression when administered to nonpotentiated pathways.
The present in vitro studies confirm these results and establish that the
susceptibility of LTP to reversal and the degree of depotentiation are
time-dependent. Specifically, a 1 min train of TPS delivered 30 sec after
LTP induction produced an almost complete and lasting depotentiation but
had increasingly less impact at longer delays and virtually no effect at 30
min. Increasing the duration of TPS did not cause more depotentiation.
However, pharmacological facilitation of AMPA receptor-mediated currents
significantly enhanced the strength of the reversal process and allowed TPS
to produce robust depotentiation up to 30 min after LTP induction. The
reversal effect was selective to potentiated synapses receiving TPS, was
reversible, and was not blocked by NMDA receptor antagonism. Additional
experiments indicated that AMPA receptor facilitation promotes
depotentiation by enhancing an active process triggered by TPS that
reverses expression without extending the time course of consolidation.
These results suggest that the mechanisms responsible for LTP reversal are
linked to the amplitude and/or duration of fast excitatory currents
mediated by synaptic AMPA receptors and are effective up to the completion
of LTP stabilization.
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