QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (112) Citing Articles via Google Scholar Google Scholar Articles by Cohen, R. I. Articles by Kessler, J. A. Search for Related Content PubMed PubMed Citation Articles by Cohen, R. I. Articles by Kessler, J. A. Pubmed/NCBI databases Substance via MeSH

 Previous Article  |  Next Article 

Volume 16, Number 20, Issue of October 15, 1996 pp. 6433-6442
Copyright ©1996 Society for Neuroscience

Nerve Growth Factor and Neurotrophin-3 Differentially Regulate the Proliferation and Survival of Developing Rat Brain Oligodendrocytes

Received Feb. 8, 1996; revised July 25, 1996; accepted July 30, 1996.

Rick I. Cohen^1, , Ronen Marmur^2, , William T. Norton^{1, 2}, Mark F. Mehler^{1, 2}, and John A. Kessler^{1, 2}

Departments of ¹ Neurology and ² Neuroscience, and the Rose F. Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, New York 10461

There is increasing evidence that the neurotrophins, particularly nerve growth factor (NGF) and neurotrophin-3 (NT-3), play a role in the regulation of glial development in the CNS. Recent studies have shown that the proliferation of optic nerve-derived O2A progenitors (OLPs) is potentiated by NT-3 in combination with platelet-derived growth factor, whereas NT-3 alone supports the survival of their differentiated progeny (). In this study, we have examined the expression of the high-affinity neurotrophin receptors (trks) and the low-affinity nerve growth factor receptor p75 in developing oligodendrocytes (OLs). In addition, we have examined the effects of NGF and NT-3 on proliferation and survival of OLPs and OLs, respectively. TrkC, the high-affinity NT-3 receptor, and trkA, the high-affinity NGF receptor, are both expressed from the early OLP through the mature OL stage. The truncated form of trkB, lacking the tyrosine kinase domain, and the low-affinity neurotrophin receptor p75 are expressed at low levels in OLPs and are upregulated in mature OLs. NGF and NT-3 both induced the phosphorylation of mitogen-activated protein kinase (MAPK) in OLPs and in OLs. In both OLPs and OLs, NT-3 sustained the activation of MAPK more than NGF. NT-3 enhanced the proliferation of OLPs and supported the survival of OLs. By contrast, unless coadministered with FGF-2, NGF did not exhibit mitogenic effects on OLPs but did enhance the survival of differentiated OLs. Our data demonstrate the presence of functional trkA and trkC in developing OLs and indicate that both NGF and NT-3 have a broad spectrum of developmental actions on cells of the OL lineage.

Key words: neurotrophins; trks; p75; MAP kinase; oligodendrocytes; proliferation; survival

This article has been cited by other articles:

				B. Stankoff, M.-S. Aigrot, F. Noel, A. Wattilliaux, B. Zalc, and C. Lubetzki Ciliary Neurotrophic Factor (CNTF) Enhances Myelin Formation: A Novel Role for CNTF and CNTF-Related Molecules J. Neurosci., November 1, 2002; 22(21): 9221 - 9227. [Abstract] [Full Text] [PDF]

				D. B. Seifer, B. Feng, R. M. Shelden, S. Chen, and C. F. Dreyfus Brain-Derived Neurotrophic Factor: A Novel Human Ovarian Follicular Protein J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 655 - 659. [Abstract] [Full Text] [PDF]

				A. Chang, A. Nishiyama, J. Peterson, J. Prineas, and B. D. Trapp NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions J. Neurosci., September 1, 2000; 20(17): 6404 - 6412. [Abstract] [Full Text] [PDF]

				P. Villoslada, S. L. Hauser, I. Bartke, J. Unger, N. Heald, D. Rosenberg, S. W. Cheung, W. C. Mobley, S. Fisher, and C. P. Genain Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System J. Exp. Med., May 15, 2000; 191(10): 1799 - 1806. [Abstract] [Full Text] [PDF]

				I. Das, J. R. Sparrow, M. I. Lin, E. Shih, T. Mikawa, and B. L. Hempstead Trk C Signaling Is Required for Retinal Progenitor Cell Proliferation J. Neurosci., April 15, 2000; 20(8): 2887 - 2895. [Abstract] [Full Text] [PDF]

				G. Booth, E. Kinrade, and A Hidalgo Glia maintain follower neuron survival during Drosophila CNS development Development, January 1, 2000; 127(2): 237 - 244. [Abstract] [PDF]

				A. Micera, A. Lambiase, P. Rama, and L. Aloe Altered nerve growth factor level in the optic nerve of patients affected by multiple sclerosis Multiple Sclerosis, December 1, 1999; 5(6): 389 - 394. [Abstract] [PDF]

				I. A. Scarisbrick, P. J. Isackson, and A. J. Windebank Differential Expression of Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4/5 in the Adult Rat Spinal Cord: Regulation by the Glutamate Receptor Agonist Kainic Acid J. Neurosci., September 15, 1999; 19(18): 7757 - 7769. [Abstract] [Full Text] [PDF]

				O. Dammann and A. Leviton Brain Damage in Preterm Newborns: Might Enhancement of Developmentally Regulated Endogenous Protection Open a Door for Prevention? Pediatrics, September 1, 1999; 104(3): 541 - 550. [Abstract] [Full Text] [PDF]

				K. J. Chandross, R. I. Cohen, P. Paras Jr, M. Gravel, P. E. Braun, and L. D. Hudson Identification and Characterization of Early Glial Progenitors Using a Transgenic Selection Strategy J. Neurosci., January 15, 1999; 19(2): 759 - 774. [Abstract] [Full Text] [PDF]

				R. Marmur, J. A. Kessler, G. Zhu, S. Gokhan, and M. F. Mehler Differentiation of Oligodendroglial Progenitors Derived from Cortical Multipotent Cells Requires Extrinsic Signals Including Activation of gp130/LIFbeta Receptors J. Neurosci., December 1, 1998; 18(23): 9800 - 9811. [Abstract] [Full Text] [PDF]

				D. M. McTigue, P. J. Horner, B. T. Stokes, and F. H. Gage Neurotrophin-3 and Brain-Derived Neurotrophic Factor Induce Oligodendrocyte Proliferation and Myelination of Regenerating Axons in the Contused Adult Rat Spinal Cord J. Neurosci., July 15, 1998; 18(14): 5354 - 5365. [Abstract] [Full Text] [PDF]

				S. O. Yoon, P. Casaccia-Bonnefil, B. Carter, and M. V. Chao Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival J. Neurosci., May 1, 1998; 18(9): 3273 - 3281. [Abstract] [Full Text] [PDF]

				U. Ladiwala, C. Lachance, S. J. J. Simoneau, A. Bhakar, P. A. Barker, and J. P. Antel p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF J. Neurosci., February 15, 1998; 18(4): 1297 - 1304. [Abstract] [Full Text] [PDF]

				R. Takano, S. Hisahara, K. Namikawa, H. Kiyama, H. Okano, and M. Miura Nerve Growth Factor Protects Oligodendrocytes from Tumor Necrosis Factor-alpha -induced Injury through Akt-mediated Signaling Mechanisms J. Biol. Chem., May 19, 2000; 275(21): 16360 - 16365. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help