 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 16, Number 20, Issue of October 15, 1996 pp. 6490-6503
Copyright ©1996 Society for Neuroscienceµ-Opioid and
-Opioid Receptors Are Expressed in Brainstem Antinociceptive Circuits: Studies Using Immunocytochemistry and Retrograde Tract-Tracing
Received May 16, 1996; revised July 10, 1996; accepted July 23, 1996.
Alexander E. Kalyuzhny, Ulf Arvidsson, Wei Wu, and Martin W. Wessendorf Department of Cell Biology and Neuroanatomy, University of Minnesota, Minneapolis, Minnesota 55455
Opioid-produced antinociception in mammals seems to be mediated in part by pathways originating in the periaqueductal gray (PAG) and the rostroventral medulla (RVM), and these pathways may include serotonergic neurons. In the present study, we examined the relationship of the cloned µ- and
-receptors (MOR1 and DOR1, respectively) to PAG neurons projecting to the RVM, and RVM neurons projecting to the dorsal spinal cord. This was carried out by combining immunocytochemical staining for MOR1, DOR1, and serotonin with fluorescent retrograde tract-tracing. Of 133 retrogradely labeled cells in the RVM, 31% were immunoreactive for MOR1. Of the double-labeled cells, 41% also were immunoreactive for 5HT. Fifty-three percent of retrogradely labeled cells were apposed by DOR1-ir varicosities; 29% of the apposed cells were immunoreactive for 5HT. In the mesencephalon, cells retrogradely labeled from the RVM were usually surrounded by MOR1-ir structures; however, retrogradely labeled cells were never observed to be immunoreactive for MOR1. Similarly, retrogradely labeled cells in the caudal midbrain were seldom, if ever, labeled for DOR1; however, they frequently were apposed by DOR1-ir varicosities. Of 156 retrogradely labeled profiles from three rats, 52 (33%) were apposed by DOR1-ir varicosities. We conclude that both µ- and
Key words: µ-opioid receptors;
This article has been cited by other articles:
S. Maione, K. Starowicz, L. Cristino, F. Guida, E. Palazzo, L. Luongo, F. Rossi, I. Marabese, V. de Novellis, and V. Di Marzo
Functional Interaction Between TRPV1 and {micro}-Opioid Receptors in the Descending Antinociceptive Pathway Activates Glutamate Transmission and Induces Analgesia
J Neurophysiol, May 1, 2009; 101(5): 2411 - 2422.
[Abstract] [Full Text] [PDF]
D. R. Loyd, X. Wang, and A. Z. Murphy
Sex Differences in {micro}-Opioid Receptor Expression in the Rat Midbrain Periaqueductal Gray Are Essential for Eliciting Sex Differences in Morphine Analgesia
J. Neurosci., December 24, 2008; 28(52): 14007 - 14017.
[Abstract] [Full Text] [PDF]
F. Wei, W. Guo, S. Zou, K. Ren, and R. Dubner
Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation
J. Neurosci., October 15, 2008; 28(42): 10482 - 10495.
[Abstract] [Full Text] [PDF]
K. Starowicz, S. Maione, L. Cristino, E. Palazzo, I. Marabese, F. Rossi, V. de Novellis, and V. Di Marzo
Tonic Endovanilloid Facilitation of Glutamate Release in Brainstem Descending Antinociceptive Pathways
J. Neurosci., December 12, 2007; 27(50): 13739 - 13749.
[Abstract] [Full Text] [PDF]
Z.-Q. Zhao, Y.-J. Gao, Y.-G. Sun, C.-S. Zhao, R. W. Gereau IV, and Z.-F. Chen
Central serotonergic neurons are differentially required for opioid analgesia but not for morphine tolerance or morphine reward
PNAS, September 4, 2007; 104(36): 14519 - 14524.
[Abstract] [Full Text] [PDF]
K. T. Sykes, S. R. White, R. W. Hurley, H. Mizoguchi, L. F. Tseng, and D. L. Hammond
Mechanisms Responsible for the Enhanced Antinociceptive Effects of {micro}-Opioid Receptor Agonists in the Rostral Ventromedial Medulla of Male Rats with Persistent Inflammatory Pain
J. Pharmacol. Exp. Ther., August 1, 2007; 322(2): 813 - 821.
[Abstract] [Full Text] [PDF]
J. Fichna, A. Janecka, J. Costentin, and J.-C. Do Rego
The Endomorphin System and Its Evolving Neurophysiological Role
Pharmacol. Rev., March 1, 2007; 59(1): 88 - 123.
[Abstract] [Full Text] [PDF]
Y. Ji, A. Z. Murphy, and R. J. Traub
Sex differences in morphine-induced analgesia of visceral pain are supraspinally and peripherally mediated
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R307 - R314.
[Abstract] [Full Text] [PDF]
J. Ma, Y. Zhang, A. E. Kalyuzhny, and Z. Z. Pan
Emergence of Functional {delta}-Opioid Receptors Induced by Long-Term Treatment with Morphine
Mol. Pharmacol., April 1, 2006; 69(4): 1137 - 1145.
[Abstract] [Full Text] [PDF]
Y.-P. Chen, S.-R. Chen, and H.-L. Pan
Systemic Morphine Inhibits Dorsal Horn Projection Neurons through Spinal Cholinergic System Independent of Descending Pathways
J. Pharmacol. Exp. Ther., August 1, 2005; 314(2): 611 - 617.
[Abstract] [Full Text] [PDF]
S. P. Hack, E. E. Bagley, B. C. H. Chieng, and M. J. Christie
Induction of {delta}-Opioid Receptor Function in the Midbrain after Chronic Morphine Treatment
J. Neurosci., March 23, 2005; 25(12): 3192 - 3198.
[Abstract] [Full Text] [PDF]
T. F. Finnegan, D.-P. Li, S.-R. Chen, and H.-L. Pan
Activation of {micro}-Opioid Receptors Inhibits Synaptic Inputs to Spinally Projecting Rostral Ventromedial Medulla Neurons
J. Pharmacol. Exp. Ther., May 1, 2004; 309(2): 476 - 483.
[Abstract] [Full Text] [PDF]
S. Marinelli, C. W. Vaughan, S. A. Schnell, M. W. Wessendorf, and M. J. Christie
Rostral Ventromedial Medulla Neurons That Project to the Spinal Cord Express Multiple Opioid Receptor Phenotypes
J. Neurosci., December 15, 2002; 22(24): 10847 - 10855.
[Abstract] [Full Text] [PDF]
R. Tao and S. B. Auerbach
Opioid Receptor Subtypes Differentially Modulate Serotonin Efflux in the Rat Central Nervous System
J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 549 - 556.
[Abstract] [Full Text] [PDF]
A. Kalra, M. O. Urban, and K. A. Sluka
Blockade of Opioid Receptors in Rostral Ventral Medulla Prevents Antihyperalgesia Produced by Transcutaneous Electrical Nerve Stimulation (TENS)
J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 257 - 263.
[Abstract] [Full Text]
R. W. Hurley and D. L. Hammond
The Analgesic Effects of Supraspinal {micro} and delta Opioid Receptor Agonists Are Potentiated during Persistent Inflammation
J. Neurosci., February 1, 2000; 20(3): 1249 - 1259.
[Abstract] [Full Text] [PDF]
L C Chiou and L-Y M Huang
Mechanism underlying increased neuronal activity in the rat ventrolateral periaqueductal grey by a {micro}-opioid
J. Physiol., July 15, 1999; 518(2): 551 - 559.
[Abstract] [Full Text] [PDF]
S. A. Schnell, W. A. Staines, and M. W. Wessendorf
Reduction of Lipofuscin-like Autofluorescence in Fluorescently Labeled Tissue
J. Histochem. Cytochem., June 1, 1999; 47(6): 719 - 730.
[Abstract] [Full Text]
A. Hayar and P. G. Guyenet
Pre- and Postsynaptic Inhibitory Actions of Methionine-Enkephalin on Identified Bulbospinal Neurons of the Rat RVL
J Neurophysiol, October 1, 1998; 80(4): 2003 - 2014.
[Abstract] [Full Text] [PDF]
M. Connor and M. J Christie
Modulation of Ca2+ channel currents of acutely dissociated rat periaqueductal grey neurons
J. Physiol., May 15, 1998; 509(1): 47 - 58.
[Abstract] [Full Text] [PDF]
K. Gao, D. O. Chen, J. R. Genzen, and P. Mason
Activation of Serotonergic Neurons in the Raphe Magnus Is Not Necessary for Morphine Analgesia
J. Neurosci., March 1, 1998; 18(5): 1860 - 1868.
[Abstract] [Full Text] [PDF]
S. N. Thorat and D. L. Hammond
Modulation of Nociception by Microinjection of Delta-1 and Delta-2 Opioid Receptor Ligands in the Ventromedial Medulla of the Rat
J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1185 - 1192.
[Abstract] [Full Text]
|
|
|
|
 |
|