 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 16, Number 20, Issue of October 15, 1996 pp. 6526-6536
Copyright ©1996 Society for NeuroscienceRespiratory Neurons Mediating the Breuer-Hering Reflex Prolongation of Expiration in Rat
Received March 6, 1996; revised July 8, 1996; accepted July 25, 1996.
Fumiaki Hayashi, Sharon K. Coles, and Donald R. McCrimmon Department of Physiology, Northwestern University Medical School, Chicago, Illinois 60611-3008
Afferent input from pulmonary stretch receptors is important in the control of the timing of inspiratory and expiratory phases of the respiratory cycle. The current study was undertaken to identify neurons within a column of respiratory neurons in the ventrolateral medulla (termed the ventral respiratory group, VRG) that, when activated by lung inflation, produce the Breuer-Hering (BH) reflex in which lung inflation causes inspiratory termination and expiratory prolongation. Intracellular recordings of VRG neurons revealed three groups of inspiratory (I) and two groups of expiratory (E) neurons similar to previous descriptions: I-augmenting (I-Aug), I-decrementing (I-Dec), I-plateau (I-All), E-augmenting (E-Aug), and E-decrementing (E-Dec) neurons. Low-intensity, low-frequency stimulation of a vagus nerve elicited paucisynaptic EPSPs in E-Dec, I-Aug, and I-All neurons that could be divided into two groups on the basis of latency (2.8 ± 0.1 msec, n = 10; 4.0 ± 0.1 msec, n = 17). IPSPs were elicited in I-Aug and I-All neurons (4.8 ± 0.1 msec, n = 12). However, only E-Dec neurons were depolarized when the BH reflex was activated by lung inflation (7.5 cm H2O) or mimicked by vagus nerve stimulation (50 Hz). All other neurons were hyperpolarized and ceased firing during BH reflex-mediated expiratory prolongation. A subset of E-Dec neurons (termed E-Decearly) discharged before inspiratory termination and could contribute to inspiratory termination. The findings are consistent with the hypothesis that a group of E-Dec neurons receives a paucisynaptic (probably disynaptic) input from pulmonary afferents and, in turn, inhibits inspiratory neurons, thereby lengthening expiration.
Key words: Breuer-Hering reflex; control of breathing; pulmonary stretch receptor; respiratory pattern; vagus nerve; ventral respiratory group
This article has been cited by other articles:
M. Dutschmann, M. Mörschel, I. A. Rybak, and T. E. Dick
Learning to breathe: control of the inspiratory\#8211;expiratory phase transition shifts from sensory- to central-dominated during postnatal development in rats
J. Physiol., October 15, 2009; 587(20): 4931 - 4948.
[Abstract] [Full Text] [PDF]
M. Morschel and M. Dutschmann
Pontine respiratory activity involved in inspiratory/expiratory phase transition
Phil Trans R Soc B, September 12, 2009; 364(1529): 2517 - 2526.
[Abstract] [Full Text] [PDF]
S. M. MacDonald, C. Tin, G. Song, and C.-S. Poon
Use-dependent learning and memory of the Hering\#8211;Breuer inflation reflex in rats
Exp Physiol, February 1, 2009; 94(2): 269 - 278.
[Abstract] [Full Text] [PDF]
S. Wittmeier, G. Song, J. Duffin, and C.-S. Poon
Pacemakers handshake synchronization mechanism of mammalian respiratory rhythmogenesis
PNAS, November 18, 2008; 105(46): 18000 - 18005.
[Abstract] [Full Text] [PDF]
A. Y. Fong and J. T. Potts
Neurokinin-1 Receptors Modulate the Excitability of Expiratory Neurons in the Ventral Respiratory Group
J Neurophysiol, February 1, 2008; 99(2): 900 - 914.
[Abstract] [Full Text] [PDF]
T. S. Moreira, A. C. Takakura, E. Colombari, and P. G. Guyenet
Activation of 5-Hydroxytryptamine Type 3 Receptor-Expressing C-Fiber Vagal Afferents Inhibits Retrotrapezoid Nucleus Chemoreceptors in Rats
J Neurophysiol, December 1, 2007; 98(6): 3627 - 3637.
[Abstract] [Full Text] [PDF]
A. C. Takakura, T. S. Moreira, G. H. West, J. M. Gwilt, E. Colombari, R. L. Stornetta, and P. G. Guyenet
GABAergic Pump Cells of Solitary Tract Nucleus Innervate Retrotrapezoid Nucleus Chemoreceptors
J Neurophysiol, July 1, 2007; 98(1): 374 - 381.
[Abstract] [Full Text] [PDF]
T. S. Moreira, A. C. Takakura, E. Colombari, G. H. West, and P. G. Guyenet
Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors
J. Physiol., April 1, 2007; 580(1): 285 - 300.
[Abstract] [Full Text] [PDF]
G. M. Stettner, P. Huppke, C. Brendel, D. W. Richter, J. Gartner, and M. Dutschmann
Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice
J. Physiol., March 15, 2007; 579(3): 863 - 876.
[Abstract] [Full Text] [PDF]
A. Y. Fong and J. T. Potts
Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea
J. Physiol., September 15, 2006; 575(3): 869 - 885.
[Abstract] [Full Text] [PDF]
L. Kubin, G. F. Alheid, E. J. Zuperku, and D. R. McCrimmon
Central pathways of pulmonary and lower airway vagal afferents
J Appl Physiol, August 1, 2006; 101(2): 618 - 627.
[Abstract] [Full Text] [PDF]
P. M. Lalley
Opiate slowing of feline respiratory rhythm and effects on putative medullary phase-regulating neurons
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1387 - R1396.
[Abstract] [Full Text] [PDF]
J. A. N. Fisher, V. A. Marchenko, A. G. Yodh, and R. F. Rogers
Spatiotemporal Activity Patterns During Respiratory Rhythmogenesis in the Rat Ventrolateral Medulla
J Neurophysiol, March 1, 2006; 95(3): 1982 - 1991.
[Abstract] [Full Text] [PDF]
M. B. Harris and W. M. St.-John
Phasic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R450 - R455.
[Abstract] [Full Text] [PDF]
M. Krolo, V. Tonkovic-Capin, A. G. Stucke, E. A. Stuth, F. A. Hopp, C. Dean, and E. J. Zuperku
Subtype Composition and Responses of Respiratory Neurons in the Pre-Botzinger Region to Pulmonary Afferent Inputs in Dogs
J Neurophysiol, May 1, 2005; 93(5): 2674 - 2687.
[Abstract] [Full Text] [PDF]
M. L Dallas, L. Atkinson, C. J Milligan, N. P Morris, D. I Lewis, S. A Deuchars, and J. Deuchars
Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii
J. Physiol., February 1, 2005; 562(3): 655 - 672.
[Abstract] [Full Text] [PDF]
N. M. Mellen, M. Roham, and J. L. Feldman
Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms
J. Physiol., May 1, 2004; 556(3): 859 - 874.
[Abstract] [Full Text] [PDF]
E. F. Bailey and R. F. Fregosi
Coordination of intrinsic and extrinsic tongue muscles during spontaneous breathing in the rat
J Appl Physiol, February 1, 2004; 96(2): 440 - 449.
[Abstract] [Full Text] [PDF]
K. Ezure, I. Tanaka, and M. Kondo
Glycine Is Used as a Transmitter by Decrementing Expiratory Neurons of the Ventrolateral Medulla in the Rat
J. Neurosci., October 1, 2003; 23(26): 8941 - 8948.
[Abstract] [Full Text] [PDF]
M. B. Harris and W. M. St.-John
Tonic pulmonary stretch receptor feedback modulates both eupnea and gasping in an in situ rat preparation
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2003; 285(1): R215 - R221.
[Abstract] [Full Text] [PDF]
A Monnier, G F Alheid, and D R McCrimmon
Defining ventral medullary respiratory compartments with a glutamate receptor agonist in the rat
J. Physiol., May 1, 2003; 548(3): 859 - 874.
[Abstract] [Full Text] [PDF]
D. L. Young, F. L. Eldridge, and C.-S. Poon
Integration-differentiation and gating of carotid afferent traffic that shapes the respiratory pattern
J Appl Physiol, March 1, 2003; 94(3): 1213 - 1229.
[Abstract] [Full Text] [PDF]
K. Ezure, I. Tanaka, and Y. Saito
Activity of Brainstem Respiratory Neurones just before the Expiration-Inspiration Transition in the Rat
J. Physiol., March 1, 2003; 547(2): 629 - 640.
[Abstract] [Full Text] [PDF]
A. M. Wasserman, M. Ferreira Jr., N. Sahibzada, Y. M. Hernandez, and R. A. Gillis
GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1423 - R1441.
[Abstract] [Full Text] [PDF]
M Dutschmann and J F R Paton
Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat
J. Physiol., September 1, 2002; 543(2): 643 - 653.
[Abstract] [Full Text] [PDF]
Y. Saito, K. Ezure, and I. Tanaka
Swallowing-related activities of respiratory and non-respiratory neurons in the nucleus of solitary tract in the rat
J. Physiol., May 1, 2002; 540(3): 1047 - 1060.
[Abstract] [Full Text] [PDF]
M. Dutschmann and J. F. R. Paton
Trigeminal reflex regulation of the glottis depends on central glycinergic inhibition in the rat
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R999 - R1005.
[Abstract] [Full Text] [PDF]
N. M. Mellen and J. L. Feldman
Phasic Vagal Sensory Feedback Transforms Respiratory Neuron Activity In Vitro
J. Neurosci., September 15, 2001; 21(18): 7363 - 7371.
[Abstract] [Full Text] [PDF]
H. Burnet, M. Bevengut, F. Chakri, C. Bou-Flores, P. Coulon, S. Gaytan, R. Pasaro, and G. Hilaire
Altered Respiratory Activity and Respiratory Regulations in Adult Monoamine Oxidase A-Deficient Mice
J. Neurosci., July 15, 2001; 21(14): 5212 - 5221.
[Abstract] [Full Text] [PDF]
E F Bailey, C L Jones, J C Reeder, D D Fuller, and R F Fregosi
Effect of pulmonary stretch receptor feedback and CO2 on upper airway and respiratory pump muscle activity in the rat
J. Physiol., April 15, 2001; 532(2): 525 - 534.
[Abstract] [Full Text] [PDF]
H. Burnet and G. Hilaire
Pulmonary stretch receptor discharges and vagal regulation of respiration differ between two mouse strains
J. Physiol., September 1, 1999; 519(2): 581 - 590.
[Abstract] [Full Text] [PDF]
Z. Li, K. F. Morris, D. M. Baekey, R. Shannon, and B. G. Lindsey
Responses of Simultaneously Recorded Respiratory-Related Medullary Neurons to Stimulation of Multiple Sensory Modalities
J Neurophysiol, July 1, 1999; 82(1): 176 - 187.
[Abstract] [Full Text] [PDF]
Z. Dogas, M. Krolo, E. A. Stuth, M. Tonkovic-Capin, F. A. Hopp, D. R. McCrimmon, and E. J. Zuperku
Differential Effects of GABAA Receptor Antagonists in the Control of Respiratory Neuronal Discharge Patterns
J Neurophysiol, November 1, 1998; 80(5): 2368 - 2377.
[Abstract] [Full Text] [PDF]
J. Orem and E. H. Vidruk
Activity of medullary respiratory neurons during ventilator-induced apnea in sleep and wakefulness
J Appl Physiol, March 1, 1998; 84(3): 922 - 932.
[Abstract] [Full Text] [PDF]
Y. Saito, K. Ezure, and I. Tanaka
Swallowing-related activities of respiratory and non-respiratory neurons in the nucleus of solitary tract in the rat
J. Physiol., May 1, 2002; 540(3): 1047 - 1060.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|