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Volume 16, Number 21, Issue of November 1, 1996 pp. 6687-6694
Copyright ©1996 Society for Neuroscience

Cloning and Functional Expression of a Drosophila Metabotropic Glutamate Receptor Expressed in the Embryonic CNS

Received June 26, 1996; revised Aug. 7, 1996; accepted Aug. 12, 1996.

Marie-Laure Parmentier, Jean-Philippe Pin, Joël Bockaert, and Yves Grau

Unité Propre de Recherche-Centre National de la Recherche Scientifique 9023, Mécanismes Moléculaires des Communications Cellulaires, Centre de Pharmacologie-Endrocrinologie, 34094 Montpellier Cedex 5, France

The excitatory neurotransmitter glutamate plays important roles in the mammalian brain, ranging from synaptic plasticity to memory. To mediate these functions, glutamate activates two types of receptors: ligand-gated channels and metabotropic receptors coupled to G-proteins. Both families of glutamate receptors share no sequence homology and possess original structural features compared with other ligand-gated channels and G-protein-coupled receptors, respectively. Glutamate-gated receptor-channel subunits have already been characterized in invertebrates. Here we report the cloning and functional characterization of an invertebrate metabotropic glutamate receptor (DmGluRA) isolated from Drosophila melanogaster. This receptor displays 45 and 43% amino acid sequence identity with its mammalian homologs mGluR3 and mGluR2, respectively. Moreover, its pharmacology and transduction mechanisms are surprisingly similar to those of mGluR2 and mGluR3. DmGluRA is expressed in the CNS of the late embryo. These results indicate that the original structural features of both glutamate receptor types are conserved from insects to mammals and suggest that the functions of these receptors have been highly conserved during evolution.

Key words: CNS; Drosophila melanogaster; glutamate; G-protein coupling; metabotropic glutamate receptor; embryogenesis; adenylyl cyclase inhibition




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