 |
 Previous Article | Next Article 
Volume 16, Number 21,
Issue of November 1, 1996
pp. 6807-6829
Copyright ©1996 Society for Neuroscience
Amino Acid Signatures in the Primate Retina
Received June 24, 1996; revised Aug. 1, 1996; accepted Aug. 14, 1996.
Michael Kalloniatis1,
Robert E. Marc2, and
Ralph
F. Murry2
1 Department of Optometry and Vision Sciences,
University of Melbourne, Parkville, Victoria 3052, Australia, and
2 John Moran Eye Center, University of Utah, Salt Lake
City, Utah 84132
Pattern recognition of amino acid signals partitions virtually all
of the macaque retina into 16 separable biochemical theme classes, some
further divisible by additional criteria. The photoreceptor bipolar
cellganglion cell pathway is composed of six separable theme
classes, each possessing a characteristic glutamate signature. Neuronal
aspartate and glutamine levels are always positively correlated with
glutamate signals, implying that they largely represent glutamate
precursor pools. Amacrine cells may be parsed into four
glycine-dominated (including one glycine/GABA immunoreactive
population) and four GABA-dominated populations. Horizontal cells in
central retina possess a distinctive GABA signature, although their
GABA content is constitutively lower than that of amacrine cells and
shows both regional and sample variability. Finally, a
taurine-glutamine signature defines Müller's cells. We thus
have established the fundamental biochemical signatures of the primate
retina along with multiple metabolic subtypes for each neurochemical
class and demonstrated that virtually all neuronal space can be
accounted for by cells bearing characteristic glutamate, GABA, or
glycine signatures.
Key words:
immunocytochemistry;
neurotransmitters;
retina;
primate;
vision;
glutamate;
GABA;
glycine;
taurine;
aspartate;
glutamine;
pattern recognition
This article has been cited by other articles:
|
|
|
|
 
N. Terada, N. Ohno, S. Saitoh, Y. Saitoh, and S. Ohno
Immunoreactivity of Glutamate in Mouse Retina Inner Segment of Photoreceptors With In Vivo Cryotechnique
J. Histochem. Cytochem.,
September 1, 2009;
57(9):
883 - 888.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Li, J. Lim, M. D. Jacobs, J. Kistler, and P. J. Donaldson
Regional Differences in Cystine Accumulation Point to a Sutural Delivery Pathway to the Lens Core
Invest. Ophthalmol. Vis. Sci.,
March 1, 2007;
48(3):
1253 - 1260.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Casini, D. W. Rickman, and N. C. Brecha
Expression of the {gamma}-Aminobutyric Acid (GABA) Plasma Membrane Transporter-1 in Monkey and Human Retina.
Invest. Ophthalmol. Vis. Sci.,
April 1, 2006;
47(4):
1682 - 1690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Arai, Y. Yamada, T. Asaka, and M. Tachibana
Light-Evoked Oscillatory Discharges in Retinal Ganglion Cells Are Generated by Rhythmic Synaptic Inputs
J Neurophysiol,
August 1, 2004;
92(2):
715 - 725.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Loeliger, T. Briscoe, G. Lambert, J. Caddy, A. Rehn, S. Dieni, and S. Rees
Chronic Placental Insufficiency Affects Retinal Development in the Guinea Pig
Invest. Ophthalmol. Vis. Sci.,
July 1, 2004;
45(7):
2361 - 2367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. McMahon, O. S. Packer, and D. M. Dacey
The Classical Receptive Field Surround of Primate Parasol Ganglion Cells Is Mediated Primarily by a Non-GABAergic Pathway
J. Neurosci.,
April 14, 2004;
24(15):
3736 - 3745.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Marc and B. W. Jones
Molecular Phenotyping of Retinal Ganglion Cells
J. Neurosci.,
January 15, 2002;
22(2):
413 - 427.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hill, M. Kalloniatis, and S.-S. Tan
Cellular Diversity in Mouse Neocortex Revealed by Multispectral Analysis of Amino Acid Immunoreactivity
Cereb Cortex,
August 1, 2001;
11(8):
679 - 690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Hill, M. Kalloniatis, and S.-S. Tan
Glutamate, GABA and Precursor Amino Acids in Adult Mouse Neocortex: Cellular Diversity Revealed by Quantitative Immunocytochemistry
Cereb Cortex,
November 1, 2000;
10(11):
1132 - 1142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Sherry and E. Townes-Anderson
Rapid Glutamatergic Alterations in the Neural Retina Induced by Retinal Detachment
Invest. Ophthalmol. Vis. Sci.,
August 1, 2000;
41(9):
2779 - 2790.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
D. I. Vaney, J. C. Nelson, and D. V. Pow
Neurotransmitter Coupling through Gap Junctions in the Retina
J. Neurosci.,
December 15, 1998;
18(24):
10594 - 10602.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Tian, T. N. Hwang, and D. R. Copenhagen
Analysis of Excitatory and Inhibitory Spontaneous Synaptic Activity in Mouse Retinal Ganglion Cells
J Neurophysiol,
September 1, 1998;
80(3):
1327 - 1340.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
