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Next Article 
Volume 16, Number 22,
Issue of November 15, 1996
pp. 7099-7108
Copyright ©1996 Society for Neuroscience
Dynamics of Induction and Expression of Long-Term Synaptic
Facilitation in Aplysia
Received May 28, 1996; revised July 12, 1996; accepted Aug. 21, 1996.
Juliane Mauelshagen,
Gretchen R. Parker, and
Thomas J. Carew
Department of Psychology, Yale University, New Haven, Connecticut
06520
Serotonin (5HT)-induced short-term facilitation and long-term
facilitation (STF and LTF) of the monosynaptic connection between tail
sensory neurons (SNs) and motor neurons (MNs) in Aplysia
have been useful in delineating possible cellular mechanisms
contributing to short-term and long-term memory. Previous work from our
laboratory showed that LTF can be produced in the absence of STF,
suggesting that these processes may be functionally independent. In the
present study, we explored this hypothesis by examining the temporal
relationship between STF and LTF. We recorded intracellularly from
pairs of monosynaptically connected SNs and MNs in isolated
pleural-pedal ganglia. In the first experimental series, we followed
the time course of LTF across a 24 hr period after its induction by
five applications of 10 µM 5HT. STF completely decayed to
baseline several hours before the expression of LTF. This biphasic
expression profile of STF and LTF further supports the hypothesis that
LTF is not a simple elaboration of STF. In the second experimental
series, we monitored the immediate expression of facilitation during
and after different numbers of 5HT applications. We identified a
rapidly decaying STF (lasting 15-30 min) after one to four pulses of
50 µM 5HT and a unique, prolonged intermediate-term
facilitation (ITF; lasting up to 90 min) after five pulses of 50 µM 5HT. These results raise the possibility that STF,
ITF, and LTF may reflect components of different memory phases in the
intact animal.
Key words:
Aplysia;
short-term facilitation;
long-term
facilitation;
time course;
sensory neurons;
serotonin;
memory
induction;
memory expression;
memory phases
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