QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (40) Citing Articles via Google Scholar Google Scholar Articles by Kidd, S. A. Articles by Kelly, J. B. Search for Related Content PubMed PubMed Citation Articles by Kidd, S. A. Articles by Kelly, J. B.

 Previous Article  |  Next Article 

Volume 16, Number 22, Issue of November 15, 1996 pp. 7390-7397
Copyright ©1996 Society for Neuroscience

Contribution of the Dorsal Nucleus of the Lateral Lemniscus to Binaural Responses in the Inferior Colliculus of the Rat: Interaural Time Delays

Received July 3, 1996; revised Aug. 27, 1996; accepted Aug. 30, 1996.

Sean A. Kidd and Jack B. Kelly

Laboratory of Sensory Neuroscience, Institute of Neuroscience and Department of Psychology, Carleton University, Ottawa, Ontario, Canada K1S 5B6

The contribution of the dorsal nucleus of the lateral lemniscus (DNLL) to binaural responses in the inferior colliculus of the rat was determined for a wide range of interaural time differences (ITDs). Single-unit action potentials were recorded from the inferior colliculus before and after local injection of the excitatory amino acid antagonist kynurenic acid into the DNLL. Binaural properties were determined by manipulating the time difference between paired clicks delivered to the ears ipsilateral and contralateral to the recording site. The probability of an action potential decreased as contralateral stimulation was delayed, relative to ipsilateral stimulation. These data generated a sigmoidal ITD curve for delays between 1.0 and +1.0 msec. By extending the time intervals beyond 1 msec, it was possible to determine the trailing edge of the inhibition produced by ipsilateral stimulation. The duration of the inhibitory effect varied from cell to cell but lasted as long as 20 msec in some cases. Injection of kynurenic acid into the DNLL contralateral to the recording site reduced the extent of both short (0-1 msec) and long-lasting (1-20 msec) inhibition in the inferior colliculus. No effect was seen after injections ipsilateral to the recording site. The data demonstrate that the DNLL plays an important role in shaping ITD responses in the inferior colliculus and contributes to both the short and long-lasting inhibition produced by stimulation of the ipsilateral ear.

Key words: binaural processing; sound localization; precedence effect; auditory spatial perception; interaural time difference

This article has been cited by other articles:

				K. A. Davis, O. Lomakin, and M. J. Pesavento Response Properties of Single Units in the Dorsal Nucleus of the Lateral Lemniscus of Decerebrate Cats J Neurophysiol, September 1, 2007; 98(3): 1475 - 1488. [Abstract] [Full Text] [PDF]

				I. Siveke, M. Pecka, A. H. Seidl, S. Baudoux, and B. Grothe Binaural Response Properties of Low-Frequency Neurons in the Gerbil Dorsal Nucleus of the Lateral Lemniscus J Neurophysiol, September 1, 2006; 96(3): 1425 - 1440. [Abstract] [Full Text] [PDF]

				D. J. Tollin, L. C. Populin, and T. C. T. Yin Neural Correlates of the Precedence Effect in the Inferior Colliculus of Behaving Cats J Neurophysiol, December 1, 2004; 92(6): 3286 - 3297. [Abstract] [Full Text] [PDF]

				E. E. Bauer, A. Klug, and G. D. Pollak Spectral Determination of Responses to Species-Specific Calls in the Dorsal Nucleus of the Lateral Lemniscus J Neurophysiol, October 1, 2002; 88(4): 1955 - 1967. [Abstract] [Full Text] [PDF]

				D. McAlpine and A. R. Palmer Blocking GABAergic Inhibition Increases Sensitivity to Sound Motion Cues in the Inferior Colliculus J. Neurosci., February 15, 2002; 22(4): 1443 - 1453. [Abstract] [Full Text] [PDF]

				R. Y. Litovsky and B. Delgutte Neural Correlates of the Precedence Effect in the Inferior Colliculus: Effect of Localization Cues J Neurophysiol, February 1, 2002; 87(2): 976 - 994. [Abstract] [Full Text] [PDF]

				R. M. Burger and G. D. Pollak Reversible Inactivation of the Dorsal Nucleus of the Lateral Lemniscus Reveals Its Role in the Processing of Multiple Sound Sources in the Inferior Colliculus of Bats J. Neurosci., July 1, 2001; 21(13): 4830 - 4843. [Abstract] [Full Text] [PDF]

				J. B. Kelly and S. A. Kidd NMDA and AMPA Receptors in the Dorsal Nucleus of the Lateral Lemniscus Shape Binaural Responses in Rat Inferior Colliculus J Neurophysiol, March 1, 2000; 83(3): 1403 - 1414. [Abstract] [Full Text] [PDF]

				A. Klug, E. E. Bauer, and G. D. Pollak Multiple Components of Ipsilaterally Evoked Inhibition in the Inferior Colliculus J Neurophysiol, August 1, 1999; 82(2): 593 - 610. [Abstract] [Full Text] [PDF]

				J. P. Oswald, A. Klug, and T. J. Park Interaural Intensity Difference Processing in Auditory Midbrain Neurons: Effects of a Transient Early Inhibitory Input J. Neurosci., February 1, 1999; 19(3): 1149 - 1163. [Abstract] [Full Text] [PDF]

				D. McAlpine, D. Jiang, T. M. Shackleton, and A. R. Palmer Convergent Input from Brainstem Coincidence Detectors onto Delay-Sensitive Neurons in the Inferior Colliculus J. Neurosci., August 1, 1998; 18(15): 6026 - 6039. [Abstract] [Full Text] [PDF]

				X. W. Fu, B. L. Brezden, and S. H. Wu Hyperpolarization-Activated Inward Current in Neurons of the Rat's Dorsal Nucleus of the Lateral Lemniscus In Vitro J Neurophysiol, November 1, 1997; 78(5): 2235 - 2245. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help