 |
Next Article 
Volume 16, Number 23,
Issue of December 1, 1996
pp. 7407-7415
Copyright ©1996 Society for Neuroscience
Cloning and Characterization of Postsynaptic Density 93, a Nitric
Oxide Synthase Interacting Protein
Received July 8, 1996; revised Sept. 4, 1996; accepted Sept. 9, 1996.
Jay E. Brenman,
Karen S. Christopherson,
Sarah E. Craven,
Aaron W. McGee, and
David S. Bredt
Department of Physiology and Programs in Biomedical Sciences and
Neuroscience, University of California at San Francisco School of
Medicine, San Francisco, California 94143-0444
Nitric oxide (NO) formation in brain is regulated by the
calcium/calmodulin dependence of neuronal NO synthase (nNOS). Calcium influx through NMDA-type glutamate receptors is efficiently coupled to
nNOS activity, whereas many other intracellular calcium pathways are
poorly coupled. To elucidate possible mechanisms responsible for this
coupling, we performed yeast two-hybrid screening to identify proteins
that interact with nNOS. Two nNOS interacting proteins were identified:
the postsynaptic density proteins PSD-93 and PSD-95. Here, we report
the cloning and characterization of PSD-93. PSD-93 is expressed in
discrete neuronal populations as well as in specific non-neuronal
cells, and it exhibits complex molecular diversity attributable to
tissue-specific alternative splicing. PSD-93, like PSD-95, binds to
nNOS and to the NMDA receptor 2B. PSD-93, however, is unique among
PSD-95/SAP-90 family members in its expression in Purkinje neuron cell
bodies and dendrites. We also demonstrate that the PDZ domain at the N
terminus of nNOS is required, but it is not sufficient for interaction
with PSD-93/95. Given that PSD-93 and PSD-95 each contain multiple
potential binding sites for nNOS and the NMDA receptor, complexes
involving oligomers of PSD-93/95 may help account for the functional as
well as the physical coupling of nNOS to NMDA receptors.
Key words:
neuronal nitric oxide synthase;
NMDA receptor;
postsynaptic density;
Purkinje neurons;
glutamate;
calcium
This article has been cited by other articles:
|
|
|
|
 
J. O. Eshcol, A. M. S. Harding, T. Hattori, V. Costa, M. J. Welsh, and C. J. Benson
Acid-sensing ion channel 3 (ASIC3) cell surface expression is modulated by PSD-95 within lipid rafts
Am J Physiol Cell Physiol,
September 1, 2008;
295(3):
C732 - C739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. W.T. Liu and P. L. Huang
Cardiovascular roles of nitric oxide: A review of insights from nitric oxide synthase gene disrupted mice
Cardiovasc Res,
January 1, 2008;
77(1):
19 - 29.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Cui, A. Hayashi, H.-S. Sun, M. P. Belmares, C. Cobey, T. Phan, J. Schweizer, M. W. Salter, Y. T. Wang, R. A. Tasker, et al.
PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors
J. Neurosci.,
September 12, 2007;
27(37):
9901 - 9915.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. I. Charych, B. F. Akum, J. S. Goldberg, R. J. Jornsten, C. Rongo, J. Q. Zheng, and B. L. Firestein
Activity-Independent Regulation of Dendrite Patterning by Postsynaptic Density Protein PSD-95
J. Neurosci.,
October 4, 2006;
26(40):
10164 - 10176.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Gsell, M. Burke, D. Wiedermann, G. Bonvento, A. C. Silva, F. Dauphin, C. Buhrle, M. Hoehn, and W. Schwindt
Differential Effects of NMDA and AMPA Glutamate Receptors on Functional Magnetic Resonance Imaging Signals and Evoked Neuronal Activity during Forepaw Stimulation of the Rat.
J. Neurosci.,
August 15, 2006;
26(33):
8409 - 8416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Melnik, M. Wright, J. A. Tanner, T. Tsintsadze, V. Tsintsadze, A. D. Miller, and N. Lozovaya
Diadenosine Polyphosphate Analog Controls Postsynaptic Excitation in CA3-CA1 Synapses via a Nitric Oxide-Dependent Mechanism
J. Pharmacol. Exp. Ther.,
August 1, 2006;
318(2):
579 - 588.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. T. Parent, N. Y. Barnes, Y. Taniguchi, G. Thinakaran, and S. S. Sisodia
Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function
J. Neurosci.,
February 9, 2005;
25(6):
1540 - 1549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. A. Waxman and D. R. Lynch
N-methyl-D-aspartate Receptor Subtypes: Multiple Roles in Excitotoxicity and Neurological Disease
Neuroscientist,
February 1, 2005;
11(1):
37 - 49.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Cao, J. I. Viholainen, C. Dart, H. K. Warwick, M. L. Leyland, and M. J. Courtney
The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death
J. Cell Biol.,
January 3, 2005;
168(1):
117 - 126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Dreyer, M. Schleicher, A. Tappe, K. Schilling, T. Kuner, G. Kusumawidijaja, W. Muller-Esterl, S. Oess, and R. Kuner
Nitric Oxide Synthase (NOS)-Interacting Protein Interacts with Neuronal NOS and Regulates Its Distribution and Activity
J. Neurosci.,
November 17, 2004;
24(46):
10454 - 10465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Leyland and C. Dart
An Alternatively Spliced Isoform of PSD-93/Chapsyn 110 Binds to the Inwardly Rectifying Potassium Channel, Kir2.1
J. Biol. Chem.,
October 15, 2004;
279(42):
43427 - 43436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-X. Tao and R. A. Johns
NEURONAL PDZ DOMAINS: A Promising New Molecular Target for Inhaled Anesthetics?
Mol. Interv.,
August 1, 2004;
4(4):
215 - 221.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Temburni, M. M. Rosenberg, N. Pathak, R. McConnell, and M. H. Jacob
Neuronal Nicotinic Synapse Assembly Requires the Adenomatous Polyposis Coli Tumor Suppressor Protein
J. Neurosci.,
July 28, 2004;
24(30):
6776 - 6784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Paliege, D. Mizel, C. Medina, A. Pasumarthy, Y. G. Huang, S. Bachmann, J. P. Briggs, J. B. Schnermann, and T. Yang
Inhibition of nNOS expression in the macula densa by COX-2-derived prostaglandin E2
Am J Physiol Renal Physiol,
July 1, 2004;
287(1):
F152 - F159.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Morabito, M. Sheng, and L.-H. Tsai
Cyclin-Dependent Kinase 5 Phosphorylates the N-Terminal Domain of the Postsynaptic Density Protein PSD-95 in Neurons
J. Neurosci.,
January 28, 2004;
24(4):
865 - 876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Parker, S. Zhao, D. S. Bredt, J. R. Sanes, and G. Feng
PSD93 Regulates Synaptic Stability at Neuronal Cholinergic Synapses
J. Neurosci.,
January 14, 2004;
24(2):
378 - 388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Jiang, D. Mu, R. A. Sheldon, D. V. Glidden, and D. M. Ferriero
Neonatal Hypoxia-Ischemia Differentially Upregulates MAGUKs and Associated Proteins in PSD-93-Deficient Mouse Brain
Stroke,
December 1, 2003;
34(12):
2958 - 2963.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nada, T. Shima, H. Yanai, H. Husi, S. G. N. Grant, M. Okada, and T. Akiyama
Identification of PSD-93 as a Substrate for the Src Family Tyrosine Kinase Fyn
J. Biol. Chem.,
November 28, 2003;
278(48):
47610 - 47621.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Fang, Y.-X. Tao, F. He, M. Zhang, C. F. Levine, P. Mao, F. Tao, C.-L. Chou, S. Sadegh-Nasseri, and R. A. Johns
Synaptic PDZ Domain-mediated Protein Interactions Are Disrupted by Inhalational Anesthetics
J. Biol. Chem.,
September 19, 2003;
278(38):
36669 - 36675.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-X. Tao, G. Rumbaugh, G.-D. Wang, R. S. Petralia, C. Zhao, F. W. Kauer, F. Tao, M. Zhuo, R. J. Wenthold, S. N. Raja, et al.
Impaired NMDA Receptor-Mediated Postsynaptic Function and Blunted NMDA Receptor-Dependent Persistent Pain in Mice Lacking Postsynaptic Density-93 Protein
J. Neurosci.,
July 30, 2003;
23(17):
6703 - 6712.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Clinton, V. Haroutunian, K. L. Davis, and J. H. Meador-Woodruff
Altered Transcript Expression of NMDA Receptor-Associated Postsynaptic Proteins in the Thalamus of Subjects With Schizophrenia
Am J Psychiatry,
June 1, 2003;
160(6):
1100 - 1109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Rumbaugh, G.-M. Sia, C. C. Garner, and R. L. Huganir
Synapse-Associated Protein-97 Isoform-Specific Regulation of Surface AMPA Receptors and Synaptic Function in Cultured Neurons
J. Neurosci.,
June 1, 2003;
23(11):
4567 - 4576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. K. Seabold, A. Burette, I. A. Lim, R. J. Weinberg, and J. W. Hell
Interaction of the Tyrosine Kinase Pyk2 with the N-Methyl-D-aspartate Receptor Complex via the Src Homology 3 Domains of PSD-95 and SAP102
J. Biol. Chem.,
April 18, 2003;
278(17):
15040 - 15048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Olsen and D. S. Bredt
Functional Analysis of the Nucleotide Binding Domain of Membrane-associated Guanylate Kinases
J. Biol. Chem.,
February 21, 2003;
278(9):
6873 - 6878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Sekerkova, P. A. Loomis, B. Changyaleket, L. Zheng, R. Eytan, B. Chen, E. Mugnaini, and J. R. Bartles
Novel Espin Actin-Bundling Proteins Are Localized to Purkinje Cell Dendritic Spines and Bind the Src Homology 3 Adapter Protein Insulin Receptor Substrate p53
J. Neurosci.,
February 15, 2003;
23(4):
1310 - 1319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. I. Nedvetsky, W. C. Sessa, and H. H. H. W. Schmidt
There's NO binding like NOS binding: Protein-protein interactions in NO/cGMP signaling
PNAS,
December 24, 2002;
99(26):
16510 - 16512.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Wu, J. E. Nash, P. Zamorano, and C. C. Garner
Interaction of SAP97 with Minus-end-directed Actin Motor Myosin VI. IMPLICATIONS FOR AMPA RECEPTOR TRAFFICKING
J. Biol. Chem.,
August 16, 2002;
277(34):
30928 - 30934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Chetkovich, R. C. Bunn, S.-H. Kuo, Y. Kawasaki, M. Kohwi, and D. S. Bredt
Postsynaptic Targeting of Alternative Postsynaptic Density-95 Isoforms by Distinct Mechanisms
J. Neurosci.,
August 1, 2002;
22(15):
6415 - 6425.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. A. Lim, D. D. Hall, and J. W. Hell
Selectivity and Promiscuity of the First and Second PDZ Domains of PSD-95 and Synapse-associated Protein 102
J. Biol. Chem.,
June 7, 2002;
277(24):
21697 - 21711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Inanobe, A. Fujita, M. Ito, H. Tomoike, K. Inageda, and Y. Kurachi
Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses
Am J Physiol Cell Physiol,
June 1, 2002;
282(6):
C1396 - C1403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Y. Hung and M. Sheng
PDZ Domains: Structural Modules for Protein Complex Assembly
J. Biol. Chem.,
February 15, 2002;
277(8):
5699 - 5702.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Miyagi, T. Yamashita, M. Fukaya, T. Sonoda, T. Okuno, K. Yamada, M. Watanabe, Y. Nagashima, I. Aoki, K. Okuda, et al.
Delphilin: a Novel PDZ and Formin Homology Domain-Containing Protein that Synaptically Colocalizes and Interacts with Glutamate Receptor delta 2 Subunit
J. Neurosci.,
February 1, 2002;
22(3):
803 - 814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Imamura, S. Maeda, T. Doi, and Y. Fujiyoshi
Ligand Binding of the Second PDZ Domain Regulates Clustering of PSD-95 with the Kv1.4 Potassium Channel
J. Biol. Chem.,
January 25, 2002;
277(5):
3640 - 3646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. McGee, J. R. Topinka, K. Hashimoto, R. S. Petralia, S. Kakizawa, F. Kauer, A. Aguilera-Moreno, R. J. Wenthold, M. Kano, and D. S. Bredt
PSD-93 Knock-Out Mice Reveal That Neuronal MAGUKs Are Not Required for Development or Function of Parallel Fiber Synapses in Cerebellum
J. Neurosci.,
May 1, 2001;
21(9):
3085 - 3091.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E.-D. El-Husseini, E. Schnell, D. M. Chetkovich, R. A. Nicoll, and D. S. Bredt
PSD-95 Involvement in Maturation of Excitatory Synapses
Science,
November 17, 2000;
290(5495):
1364 - 1368.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Maudsley, A. M. Zamah, N. Rahman, J. T. Blitzer, L. M. Luttrell, R. J. Lefkowitz, and R. A. Hall
Platelet-Derived Growth Factor Receptor Association with Na+/H+ Exchanger Regulatory Factor Potentiates Receptor Activity
Mol. Cell. Biol.,
November 15, 2000;
20(22):
8352 - 8363.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. S. Mandir, M. F. Poitras, A. R. Berliner, W. J. Herring, D. B. Guastella, A. Feldman, G. G. Poirier, Z.-Q. Wang, T. M. Dawson, and V. L. Dawson
NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase
J. Neurosci.,
November 1, 2000;
20(21):
8005 - 8011.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Walikonis, O. N. Jensen, M. Mann, D. W. Provance Jr, J. A. Mercer, and M. B. Kennedy
Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry
J. Neurosci.,
June 1, 2000;
20(11):
4069 - 4080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Shin, Y.-P. Hsueh, F.-C. Yang, E. Kim, and M. Sheng
An Intramolecular Interaction between Src Homology 3 Domain and Guanylate Kinase-Like Domain Required for Channel Clustering by Postsynaptic Density-95/SAP90
J. Neurosci.,
May 15, 2000;
20(10):
3580 - 3587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Sans, R. S. Petralia, Y.-X. Wang, J. Blahos II, J. W. Hell, and R. J. Wenthold
A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses
J. Neurosci.,
February 1, 2000;
20(3):
1260 - 1271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. El-Husseini, S. E. Craven, D. M. Chetkovich, B. L. Firestein, E. Schnell, C. Aoki, and D. S. Bredt
Dual Palmitoylation of PSD-95 Mediates Its Vesiculotubular Sorting, Postsynaptic Targeting, and Ion Channel Clustering
J. Cell Biol.,
January 10, 2000;
148(1):
159 - 172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Claudepierre, C Dalloz, D Mornet, K Matsumura, J Sahel, and A Rendon
Characterization of the intermolecular associations of the dystrophin-associated glycoprotein complex in retinal Muller glial cells
J. Cell Sci.,
January 10, 2000;
113(19):
3409 - 3417.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Sattler, Z. Xiong, W.-Y. Lu, J. F. MacDonald, and M. Tymianski
Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity
J. Neurosci.,
January 1, 2000;
20(1):
22 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Wang
Regulation of the ROMK channel: interaction of the ROMK with associate proteins
Am J Physiol Renal Physiol,
December 1, 1999;
277(6):
F826 - F831.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Lim, S. Naisbitt, J. Yoon, J.-I. Hwang, P.-G. Suh, M. Sheng, and E. Kim
Characterization of the Shank Family of Synaptic Proteins. MULTIPLE GENES, ALTERNATIVE SPLICING, AND DIFFERENTIAL EXPRESSION IN BRAIN AND DEVELOPMENT
J. Biol. Chem.,
October 8, 1999;
274(41):
29510 - 29518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Boeckers, M. R. Kreutz, C. Winter, W. Zuschratter, K.-H. Smalla, L. Sanmarti-Vila, H. Wex, K. Langnaese, J. Bockmann, C. C. Garner, et al.
Proline-Rich Synapse-Associated Protein-1/Cortactin Binding Protein 1 (ProSAP1/CortBP1) Is a PDZ-Domain Protein Highly Enriched in the Postsynaptic Density
J. Neurosci.,
August 1, 1999;
19(15):
6506 - 6518.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hayashi, M. Nishio, Y. Naito, H. Yokokura, Y. Nimura, H. Hidaka, and Y. Watanabe
Regulation of Neuronal Nitric-oxide Synthase by Calmodulin Kinases
J. Biol. Chem.,
July 16, 1999;
274(29):
20597 - 20602.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Sattler, Z. Xiong, W. Lu, M. Hafner, J. F. MacDonald, and M. Tymianski
Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein
Science,
June 11, 1999;
284(5421):
1845 - 1848.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. W. Roche, C. D. Ly, R. S. Petralia, Y.-X. Wang, A. W. McGee, D. S. Bredt, and R. J. Wenthold
Postsynaptic Density-93 Interacts with the delta 2 Glutamate Receptor Subunit at Parallel Fiber Synapses
J. Neurosci.,
May 15, 1999;
19(10):
3926 - 3934.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. L. Firestein and D. S. Bredt
Interaction of Neuronal Nitric-oxide Synthase and Phosphofructokinase-M
J. Biol. Chem.,
April 9, 1999;
274(15):
10545 - 10550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Zhang, L. Vazquez, M. Apperson, and M. B. Kennedy
Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus
J. Neurosci.,
January 1, 1999;
19(1):
96 - 108.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Veltkamp, F. Domoki, F. Bari, T. M. Louis, D. W. Busija, and F. M. Faraci
Inhibitors of Protein Synthesis Preserve the N-Methyl-D-Aspartate–Induced Cerebral Arteriolar Dilation After Ischemia in Piglets • Editorial Comment
Stroke,
January 1, 1999;
30(1):
148 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Inglis, F. Furia, K. E. Zuckerman, S. M. Strittmatter, and R. G. Kalb
The Role of Nitric Oxide and NMDA Receptors in the Development of Motor Neuron Dendrites
J. Neurosci.,
December 15, 1998;
18(24):
10493 - 10501.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-S. Fan, Q. Zhang, M. Li, H. Tochio, T. Yamazaki, M. Shimizu, and M. Zhang
Protein Inhibitor of Neuronal Nitric-oxide Synthase, PIN, Binds to a 17-Amino Acid Residue Fragment of the Enzyme
J. Biol. Chem.,
December 11, 1998;
273(50):
33472 - 33481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Koulen, E. L. Fletcher, S. E. Craven, D. S. Bredt, and H. Wassle
Immunocytochemical Localization of the Postsynaptic Density Protein PSD-95 in the Mammalian Retina
J. Neurosci.,
December 1, 1998;
18(23):
10136 - 10149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kimura, S. Uchiyama, H. E. Takahashi, and K. Shibuki
cAMP-Dependent Long-Term Potentiation of Nitric Oxide Release from Cerebellar Parallel Fibers in Rats
J. Neurosci.,
November 1, 1998;
18(21):
8551 - 8558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Brenman, J. R. Topinka, E. C. Cooper, A. W. McGee, J. Rosen, T. Milroy, H. J. Ralston, and D. S. Bredt
Localization of Postsynaptic Density-93 to Dendritic Microtubules and Interaction with Microtubule-Associated Protein 1A
J. Neurosci.,
November 1, 1998;
18(21):
8805 - 8813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bhardwaj, M. Sawada, E. D. London, R. C. Koehler, R. J. Traystman, J. R. Kirsch, and F. M. Faraci
Potent {varsigma}1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl) Piperidine Modulates Basal and N-Methyl-D-Aspartate–Evoked Nitric Oxide Production In Vivo • Editorial Comment
Stroke,
November 1, 1998;
29(11):
2404 - 2411.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. H. Gee, S. A. Sekely, C. Lombardo, A. Kurakin, S. C. Froehner, and B. K. Kay
Cyclic Peptides as Non-carboxyl-terminal Ligands of Syntrophin PDZ Domains
J. Biol. Chem.,
August 21, 1998;
273(34): | |
