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Volume 16, Number 23, Issue of December 1, 1996 pp. 7638-7648
Copyright ©1996 Society for Neuroscience

Restriction in Cell Fates of Developing Spinal Cord Cells Transplanted to Neural Crest Pathways

Received Aug. 7, 1996; accepted Sept. 5, 1996.

eljka Korade and Eric Frank

Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261

At early neural tube stages, individual stem cells can generate neural crest cells as well as dorsal or ventral spinal cord cells. To determine whether this pluripotency is lost as development proceeds, we back-transplanted quail spinal cells from different developmental stages and different spinal locations into the crest migratory pathways of st 16-20 chicken host embryos. The transplanted spinal cells from st 27 dorsal cord and st 18 ventral cord differentiated within the new crest environment into sensory and sympathetic neurons, satellite and Schwann cells, and melanocytes. St 27 ventral cells still generated several crest derivatives but not sensory or sympathetic neurons. This loss in ability to produce neurons correlates with the end of neurogenesis in ventral cord. The end of neurogenesis in the cord, therefore, results from an intrinsic change in the potential of spinal neuroepithelial cells to generate neurons.

Key words: neuroepithelial cells; cell fate; cell determination; neural crest; spinal cord; transplantation

This article has been cited by other articles:

				M. H. M. Sailer, T. G. Hazel, D. M. Panchision, D. J. Hoeppner, M. E. Schwab, and R. D. G. McKay BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells J. Cell Sci., December 15, 2005; 118(24): 5849 - 5860. [Abstract] [Full Text] [PDF]

				K Sharma and E Frank Sensory axons are guided by local cues in the developing dorsal spinal cord Development, January 2, 1998; 125(4): 635 - 643. [Abstract] [PDF]

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