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Volume 16, Number 23,
Issue of December 1, 1996
pp. 7649-7660
Copyright ©1996 Society for Neuroscience
The Expression Pattern of the Transcription Factor Phox2
Delineates Synaptic Pathways of the Autonomic Nervous System
Received July 9, 1996; revised Sept. 4, 1996; accepted Sept. 9, 1996.
Marie-Catherine Tiveron,
Marie-Rose Hirsch, and
Jean-François Brunet
Laboratoire de Génétique et Physiologie du
Développement, Institut de Biologie du Développement de
Marseille, Centre National de la Recherche Scientifique-Institut
National de la Santé et de la Recherche
Médicale-Université de la Méditerranée, Luminy
Case 907, 13288 Marseille Cedex 09, France
Many transcription factors, and most prominently among them,
homeodomain proteins, are expressed in specific groups of cells in the
developing nervous system in patterns that suggest their involvement in
neural fate determination. How various aspects of neural identity are
controlled by such transcription factors, or sets of them, is still
mostly unknown. It has been shown previously that Phox2 is such a
homeodomain protein, expressed exclusively in differentiated groups of
neurons or their precursors, and that its expression correlated with
that of the noradrenaline synthesis enzyme dopamine- -hydroxylase.
Here we confirm this striking correlation at the single-cell level with
the use of an anti-Phox2 antibody. Moreover, we uncover a second,
nonmutually exclusive correlative clue to the Phox2 expression pattern:
a high proportion of Phox2-expressing cells are involved in, or located
in areas involved in, synaptic circuits, i.e., that of the medullary
control reflexes of autonomic functions. This suggests that Phox2 could
be involved in the establishment of these circuits.
Key words:
homeodomain proteins;
autonomic nervous system;
synapse;
neurotransmitter;
dopamine--hydroxylase;
choline acetyltransferase;
sympathetic system;
parasympathetic system
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