WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Introducing ALZET?ew Model 2006 Pump
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by LeSauteur, L.
Right arrow Articles by Saragovi, H. U.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by LeSauteur, L.
Right arrow Articles by Saragovi, H. U.
Right arrowPubmed/NCBI databases
*Substance via MeSH

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 16, 1308-1316, Copyright © 1996 by Society for Neuroscience

ARTICLE

Potent human p140-TrkA agonists derived from an anti-receptor monoclonal antibody

L LeSauteur, S Maliartchouk, H Le Jeune, R Quirion and HU Saragovi
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

Monoclonal antibody (mAb) 5C3 directed against human p140 TrkA is a structural and functional mimic of nerve growth factor (NGF) and an artificial receptor agonist. mAb 5C3 binds in the NGF-docking site and, like NGF, it promotes TrkA internalization, TrkA and phosphatidylinositol-3 kinase tyrosine phosphorylation, and increased transformation of TrkA-expressing fibroblasts. More important, mAb 5C3 protects human TrkA-expressing cells from apoptotic death in serum-free media. Interestingly, agonistic activity is observed with monomeric F(ab) 5C3 fragments. mAb 5C3 (Kd approximately 2 nM) was used to study features of ligand binding by TrkA and the distribution of TrkA protein in normal human brain.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
L. Ivanisevic, W. Zheng, S. B. Woo, K. E. Neet, and H. U. Saragovi
TrkA Receptor "Hot Spots" for Binding of NT-3 as a Heterologous Ligand
J. Biol. Chem., June 8, 2007; 282(23): 16754 - 16763.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Varsano, M.-Q. Dong, I. Niesman, H. Gacula, X. Lou, T. Ma, J. R. Testa, J. R. Yates III, and M. G. Farquhar
GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling
Mol. Cell. Biol., December 1, 2006; 26(23): 8942 - 8952.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. D. Qian, J. Zhang, X.-Y. Tan, A. Wood, D. Gill, and S. Cho
Novel Agonist Monoclonal Antibodies Activate TrkB Receptors and Demonstrate Potent Neurotrophic Activities.
J. Neurosci., September 13, 2006; 26(37): 9394 - 9403.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Moog-Lutz, J. Degoutin, J. Y. Gouzi, Y. Frobert, N. B.-d. Carvalho, J. Bureau, C. Creminon, and M. Vigny
Activation and Inhibition of Anaplastic Lymphoma Kinase Receptor Tyrosine Kinase by Monoclonal Antibodies and Absence of Agonist Activity of Pleiotrophin
J. Biol. Chem., July 15, 2005; 280(28): 26039 - 26048.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Motegi, J. Fujimoto, M. Kotani, H. Sakuraba, and T. Yamamoto
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth
J. Cell Sci., July 1, 2004; 117(15): 3319 - 3329.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. M. Campbell, V. Bovenzi, and M. Szyf
Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo
Carcinogenesis, April 1, 2004; 25(4): 499 - 507.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. Yan, Y. Liang, K. D. Nylander, J. Wong, R. M. Rudavsky, H. U. Saragovi, and N. F. Schor
p75-Nerve Growth Factor as an Antiapoptotic Complex: Independence versus Cooperativity in Protection from Enediyne Chemotherapeutic Agents
Mol. Pharmacol., April 1, 2002; 61(4): 710 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. Guillemard and H. U. Saragovi
Taxane-Antibody Conjugates Afford Potent Cytotoxicity, Enhanced Solubility, and Tumor Target Selectivity
Cancer Res., January 1, 2001; 61(2): 694 - 699.
[Abstract] [Full Text]

Home page
 J. Leukoc. Biol.Home page
A. la Sala, S. Corinti, M. Federici, H. U. Saragovi, and G. Girolomoni
Ligand activation of nerve growth factor receptor TrkA protects monocytes from apoptosis
J. Leukoc. Biol., July 1, 2000; 68(1): 104 - 110.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
S. Maliartchouk, T. Debeir, N. Beglova, A. C. Cuello, K. Gehring, and H. U. Saragovi
Genuine Monovalent Ligands of TrkA Nerve Growth Factor Receptors Reveal a Novel Pharmacological Mechanism of Action
J. Biol. Chem., March 31, 2000; 275(14): 9946 - 9956.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Maliartchouk, Y. Feng, L. Ivanisevic, T. Debeir, A. C. Cuello, K. Burgess, and H. U. Saragovi
A Designed Peptidomimetic Agonistic Ligand of TrkA Nerve Growth Factor Receptors
Mol. Pharmacol., February 1, 2000; 57(2): 385 - 391.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
A. Cattaneo, S. Capsoni, E. Margotti, M. Righi, E. Kontsekova, P. Pavlik, P. Filipcik, and M. Novak
Functional Blockade of Tyrosine Kinase A in the Rat Basal Forebrain by a Novel Antagonistic Anti-Receptor Monoclonal Antibody
J. Neurosci., November 15, 1999; 19(22): 9687 - 9697.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. U. Saragovi, W. Zheng, S. Maliartchouk, G. M. DiGugliemo, Y. R. Mawal, A. Kamen, S. B. Woo, A. C. Cuello, T. Debeir, and K. E. Neet
A TrkA-selective, Fast Internalizing Nerve Growth Factor-Antibody Complex Induces Trophic but Not Neuritogenic Signals
J. Biol. Chem., December 25, 1998; 273(52): 34933 - 34940.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Maliartchouk and H. U. Saragovi
Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands
J. Neurosci., August 15, 1997; 17(16): 6031 - 6037.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Shanmugam, M. S. Featherstone, and H. U. Saragovi
Residues Flanking the HOX YPWM Motif Contribute to Cooperative Interactions with PBX
J. Biol. Chem., July 25, 1997; 272(30): 19081 - 19087.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-