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Journal of Neuroscience, Vol 16, 1770-1779, Copyright © 1996 by Society for Neuroscience
CEPU-1, a novel immunoglobulin superfamily molecule, is expressed by developing cerebellar Purkinje cells
F Spaltmann and T Brummendorf
Max-Planck-Institut fur Entwicklungsbiologie, Tubingen, Germany.
Proteins of the immunoglobulin superfamily (IgSF) are involved in a variety
of specific cell-cell interactions in the developing nervous system. We
used a systematic approach, based on the PCR, to identify and characterize
new members of this protein family in the developing chick nervous system.
In this study, we report on CEPU-1, a new IgSF protein that is strongly
expressed in developing Purkinje neurons in the cerebellum and is
detectable on the dendrites, somata, and axons of these cells. The timing
of CEPU-1 expression coincides with the growth of the dendritic tree--after
the Purkinje cells have finished their migration from the ventricular zone.
CEPU-1 is a 51 kDa glycoprotein comprised of three Ig-like domains of the
C2 subcategory and is anchored to the plasma membrane via a
post-translationally attached glycosyl-phosphatidylinositol moiety. The
protein shows high sequence similarity to the neurotrimin glycoprotein (78%
identity), to the opioid-binding cell adhesion molecule (or OBCAM; 68%
identity), and to the limbic system-associated membrane protein (or LAMP;
54% identity). Our results suggest that CEPU-1 may serve as a cellular
identification marker that is specific for developing Purkinje cells.
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