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Journal of Neuroscience, Vol 16, 1877-1893, Copyright © 1996 by Society for Neuroscience
Basal amygdaloid complex afferents to the rat nucleus accumbens are compartmentally organized
CI Wright, AV Beijer and HJ Groenewegen
Graduate School Neurosciences Amsterdam, Department of Anatomy and Embryology, Vrije Universiteit, Amsterdam, The Netherlands.
The basal amygdaloid complex (BAC) topographically projects to the nucleus
accumbens (Acb) in patchy, inhomogeneous patterns. These termination
patterns may be related to the histological features of the Acb that define
the shell, core, and adjacent ventral caudate-putamen (CPv), and the
ventral striatal compartments providing output to different autonomic,
motor, and endocrine targets. Knowledge of the relationships of BAC
afferents with these compartments is essential for understanding the
activities of amygdalostriatal circuits. Therefore, anterograde tracing
experiments were performed, combined with calbindin- D28K (CaB)
immunohistochemistry or Nissl staining. The results demonstrated that the
caudal parvicellular basal amygdala (Bpc) projected primarily to cell
clusters in the dorsal shell of the medial Acb, and to patches in the
core/CPv. Fibers from the caudal accessory basal nucleus (AB) selectively
reached CaB-immunoreactive cell clusters in the ventral shell, avoiding the
core/CPv. The rostral AB projected to the same ventral shell compartments
as the caudal AB; in addition, dense terminations were found in the matrix
of the core/CPv, avoiding the patches. Caudal magnocellular basal amygdala
(Bmg) fibers reached ventral parts of the shell, including the
CaB-immunoreactive cell clusters. The caudal Bmg projected strongly to the
patches of the core/CPv, evading the matrix. Finally, the rostral Bmg
densely innervated the moderately CaB-immunoreactive lateral shell and the
patches of the core/CPv, largely avoiding the matrix. These results
indicate the specific compartmental relationships of the patchy BAC
terminations and suggest that BAC subregions differentially influence
particular ventral striatal outputs.
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