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Journal of Neuroscience, Vol 16, 2057-2063, Copyright © 1996 by Society for Neuroscience

ARTICLE

A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice

U Frey, M Muller and D Kuhl
Federal Institute for Neurobiology, Magdeburg, Germany.

The establishment of hippocampal long-term (LTP) requires protein and mRNA synthesis, suggesting that neuronal activity resulting in LTP initiates a cascade of gene expression. The expression of the gene for the extracellular serine protease tissue plasminogen activator (t-PA) is induced during LTP. Here we analyze long-lasting LTP (L-LTP,>4 hr)in CA1 hippocampal slices of mice homozygous for disrupted t-PA genes. Although mutant mice appear to exhibit long-term potentiation, we provide evidence that these mice are devoid of conventional homosynaptic L-LTP at the Schaffer collateral-CA1 pyramidal cell synapse. Most remarkably, t-PA-deficient mice exhibit a different form of long-lasting potentiation that is characterized by an NMDA receptor- dependent modification of GABA transmission in the CA1 region.


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