 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 2283-2293, Copyright © 1996 by Society for Neuroscience
Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall
ES Anton, RS Cameron and P Rakic
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510-8001, USA.
To identify glial membrane proteins that contribute to the process of
neuronal migration in the developing brain, we developed a polyclonal
antiserum (D4) and a monoclonal antibody (NJPA1: neuron-glial junctional
polypeptide antibody) that recognize membrane proteins localized to the
plasmalemmal junction between migrating neurons and adjacent radial glial
fibers (Cameron and Rakic, 1994). Here, we show that in the developing
cerebral cortex, immunoreactivity for these junctional polypeptides is
present throughout the neuronal migratory pathway but becomes minimal or
absent where radial glial cell processes enter the marginal zone region,
the barrier at which newly arrived neurons normally stop their migration
and detach from their glial fiber substrate. We thus tested, using imprints
of embryonic cerebral wall and slice preparations, whether the junctional
membrane proteins detected by our antibodies contribute to the regulation
of neuronal migration in the cerebral cortex. The rate of neuronal
migration on glial cell substrates was reduced significantly in the
presence of D4 or NJPA1 antibodies. Antibody exposure typically led to the
withdrawal of leading processes, changes in microtubular organization and,
in some instances, to detachment of neurons from their glial cell
substrates. These results suggest that the polypeptides recognized by the
D4 and NJPA1 antibodies are essential for the maintenance of normal
neuronal migration. Dismantling of neuron-glial cell junctional domains
formed by these membrane proteins may underlie neuronal cell detachment
from glial migratory substrates at the interface between cortical plate and
marginal zone in the developing cerebral wall.
This article has been cited by other articles:
|
|
|
|
 
J. M. Weimer, Y. Yokota, A. Stanco, D. J. Stumpo, P. J. Blackshear, and E.S. Anton
MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex
Development,
September 1, 2009;
136(17):
2965 - 2975.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Causeret, M. Terao, T. Jacobs, Y. V. Nishimura, Y. Yanagawa, K. Obata, M. Hoshino, and M. Nikolic
The p21-Activated Kinase Is Required for Neuronal Migration in the Cerebral Cortex
Cereb Cortex,
April 1, 2009;
19(4):
861 - 875.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. Howard, Zhicheng Mo, R. Filipovic, A. R. Moore, S. D. Antic, and N. Zecevic
Radial Glia Cells in the Developing Human Brain
Neuroscientist,
October 1, 2008;
14(5):
459 - 473.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. S. Schmid, R. Jo, S. Shelton, J. A. Kreidberg, and E. S. Anton
Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development
Cereb Cortex,
October 1, 2005;
15(10):
1632 - 1636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. McManus and J. A. Golden
Topical Review: Neuronal Migration in Developmental Disorders
J Child Neurol,
April 1, 2005;
20(4):
280 - 286.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. S. Schmid, S. Shelton, A. Stanco, Y. Yokota, J. A. Kreidberg, and E. S. Anton
{alpha}3{beta}1 integrin modulates neuronal migration and placement during early stages of cerebral cortical development
Development,
December 15, 2004;
131(24):
6023 - 6031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Sidera, M. Samiotaki, E. Yfanti, G. Panayotou, and E. Patsavoudi
Involvement of Cell Surface HSP90 in Cell Migration Reveals a Novel Role in the Developing Nervous System
J. Biol. Chem.,
October 29, 2004;
279(44):
45379 - 45388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Siegenthaler and M. W. Miller
Transforming Growth Factor {beta}1 Modulates Cell Migration in Rat Cortex: Effects of Ethanol
Cereb Cortex,
July 1, 2004;
14(7):
791 - 802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. F. McManus and J. A. Golden
Topical Review: Neuronal Migration in Developmental Disorders
J Child Neurol,
March 1, 2004;
19(3):
280 - 286.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Y. Jossin, M. Ogawa, C. Metin, F. Tissir, and A. M. Goffinet
Inhibition of Src Family Kinases and Non-Classical Protein Kinases C Induce a Reeler-Like Malformation of Cortical Plate Development
J. Neurosci.,
October 29, 2003;
23(30):
9953 - 9959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Rakic
Developmental and Evolutionary Adaptations of Cortical Radial Glia
Cereb Cortex,
June 1, 2003;
13(6):
541 - 549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Adams, T. Tomoda, M. Cooper, G. Dietz, and M. E. Hatten
Mice that lack astrotactin have slowed neuronal migration
Development,
March 4, 2003;
129(4):
965 - 972.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Rao, K. Wong, M. Ward, C. Jurgensen, and J. Y. Wu
Neuronal migration and molecular conservation with leukocyte chemotaxis
Genes & Dev.,
December 1, 2002;
16(23):
2973 - 2984.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Yacubova and H. Komuro
Intrinsic Program for Migration of Cerebellar Granule Cells In Vitro
J. Neurosci.,
July 15, 2002;
22(14):
5966 - 5981.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Thelen, V. Kedar, A. K. Panicker, R.-S. Schmid, B. R. Midkiff, and P. F. Maness
The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins
J. Neurosci.,
June 15, 2002;
22(12):
4918 - 4931.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Meyer
Book Review: Human Neocortical Development: The Importance of Embryonic and Early Fetal Events
Neuroscientist,
August 1, 2001;
7(4):
303 - 314.
[Abstract]
[PDF]
|
|
|
|
|
|
|
N. Zecevic and P. Rakic
Development of Layer I Neurons in the Primate Cerebral Cortex
J. Neurosci.,
August 1, 2001;
21(15):
5607 - 5619.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Super, J. A. Del Rio, A. Martinez, P. Perez-Sust, and E. Soriano
Disruption of Neuronal Migration and Radial Glia in the Developing Cerebral Cortex Following Ablation of Cajal-Retzius Cells
Cereb Cortex,
June 1, 2000;
10(6):
602 - 613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Heffron and J. A. Golden
DM-GRASP Is Necessary for Nonradial Cell Migration during Chick Diencephalic Development
J. Neurosci.,
March 15, 2000;
20(6):
2287 - 2294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Meyer, A. M. Goffinet, and A. Fairen
Feature Article: What is a Cajal-Retzius cell? A Reassessment of a Classical Cell Type Based on Recent Observations in the Developing Neocortex
Cereb Cortex,
December 1, 1999;
9(8):
765 - 775.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Aboitiz
Feature Article: Comparative Development of the Mammalian Isocortex and the Reptilian Dorsal Ventricular Ridge. Evolutionary Considerations
Cereb Cortex,
December 1, 1999;
9(8):
783 - 791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Millen, J. H. Millonig, R. J. T. Wingate, J. Alder, and M. E. Hatten
Neurogenetics of the Cerebellar System
J Child Neurol,
September 1, 1999;
14(9):
574 - 581.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. M. Mulrenin, J. W. Witkin, and A.-J. Silverman
Embryonic Development of the Gonadotropin-Releasing Hormone (GnRH) System in the Chick: A Spatio-Temporal Analysis of GnRH Neuronal Generation, Site of Origin, and Migration
Endocrinology,
January 1, 1999;
140(1):
422 - 433.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Alcantara, M. Ruiz, G. D'Arcangelo, F. Ezan, L. de Lecea, T. Curran, C. Sotelo, and E. Soriano
Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse
J. Neurosci.,
October 1, 1998;
18(19):
7779 - 7799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Komuro and P. Rakic
Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
J. Neurosci.,
February 15, 1998;
18(4):
1478 - 1490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Rice, M Sheldon, G D'Arcangelo, K Nakajima, D Goldowitz, and T Curran
Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
Development,
January 9, 1998;
125(18):
3719 - 3729.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. L. Cameron, J. W. Ruffin, R. Bollag, H. Rasmussen, and R. S. Cameron
Identification of Caveolin and Caveolin-Related Proteins in the Brain
J. Neurosci.,
December 15, 1997;
17(24):
9520 - 9535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Anton, M. Marchionni, K. Lee, and P Rakic
Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex
Development,
January 9, 1997;
124(18):
3501 - 3510.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Golden, J. Zitz, K McFadden, and C. Cepko
Cell migration in the developing chick diencephalon
Development,
January 9, 1997;
124(18):
3525 - 3533.
[Abstract]
[PDF]
|
|
|
|
|
