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Journal of Neuroscience, Vol 16, 2452-2462, Copyright © 1996 by Society for Neuroscience
Myelin basic protein gene expression in neurons: developmental and regional changes in protein targeting within neuronal nuclei, cell bodies, and processes
CF Landry, JA Ellison, TM Pribyl, C Campagnoni, K Kampf and AT Campagnoni
Mental Retardation Research Center, Neuropsychiatric Institute, University of California at Los Angeles School of Medicine, California 90024, USA.
The myelin basic protein (MBP) gene is part of the golli-mbp gene complex.
In mouse, the golli-mbp gene produces two families of mRNAs from different
transcription start sites that generate either MBPs or golli proteins
(which contain MBP sequences in addition to unique peptide sequences). In
situ hybridization and immunocytochemical analyses indicate that golli
products are expressed in selected neuronal populations in postnatal mouse
brain, in addition to oligodendrocytes, as shown earlier. The principal
subcellular location of golli proteins in neurons was in axonal and
dendritic processes. In a small subset of neurons, golli proteins were
located in nuclei. With development and neuronal maturation, golli-mbp
expression decreased and/or there was a striking shift in subcellular
localization from nuclei and cell soma to the cell processes in specific
neuronal populations. Golli protein was localize in neurites of migrating
cerebellar granule cells, but it shifted to a nuclear localization when the
cells took up residence in the internal granule cell layer. In some
regions, (e.g., olfactory bulb and cerebellum) golli proteins were
expressed over the entire postnatal period examined (birth to 75 d). The
unique patterns of developmental expression within individual populations
of neurons, and the unusual shift in subcellular localization of golli
proteins with neuronal migration and maturation, suggest a complex
regulation of this gene at both the transcriptional and posttranslational
levels. The data also suggest that the cellular function(s) of the golli
proteins is very different from the structurally related MBPs.
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