 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 2605-2611, Copyright © 1996 by Society for Neuroscience
The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain
BH Westerink, HF Kwint and JB deVries
Department of Medicinal Chemistry, University Center for Pharmacy, University of Groningen, The Netherlands.
Receptor-specific compounds were applied by retrograde microdialysis to the
ventral tegmental area (VTA) of the rat brain. The effect of the
intrategmental infusions on extracellular dopamine in the ipsilateral
nucleus accumbens were recorded with a second microdialysis probe.
Intrategmental infusion of muscimol (10-40 microM) or baclofen (50 microM)
decreased extracellular dopamine in the nucleus accumbens. Intrategmental
infusion of NMDA (1 mM, 15 min) or kainate (50 microM, 15 min) increased
extracellular dopamine in the nucleus accumbens. The effects of the
excitatory amino acids were suppressed by co-infusion of MK-801 (1 MM),
(+)-3-amino-1-hydroxy-2-pyrrolidone [(+)-HA966; 1 mM],
(+/-)-3(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP; 100
microM), and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX;300 microM).
Intrategmental infusion of of carbachol (50 microM) increased extracellular
dopamine in the nucleus accumbens. These results provide evidence for
localization of GABAA, GABAB NMDA, non-NMDA, and cholinergic receptors on
dopamine neurons in the VTA. Infusions of CPP, (+)-MK-801, (+)-HA966, CNQX,
mecamylamine, atropine, or 3-[[(3,4-
dichlorophenyl)methyl]propyl](diethoxymethyl) phosphonic acid (CGP 52432)
into the VTA did not modify extracellular dopamine in the nucleus
accumbens. Infusion of bicuculline (50 microM) and (-)- sulpiride (50
microM) was followed by an increase in extracellular dopamine in the
nucleus accumbens. These data suggest that dopamine neurons in the VTA are
tonically inhibited by GABA and dopamine by acting on GABAA, and D2
receptors, respectively. A tonic stimulation by glutamatergic or
cholinergic neurons was not detected. Finally, results on A10 neurons are
compared with earlier data on A9 neurons. A striking difference was found
in that GABAA-dopamine interactions are indirect in the substantia nigra
and direct in the VTA.
This article has been cited by other articles:
|
|
|
|
 
C. R. Yang and L. Chen
Targeting Prefrontal Cortical Dopamine D1 and N-Methyl-D-Aspartate Receptor Interactions in Schizophrenia Treatment
Neuroscientist,
October 1, 2005;
11(5):
452 - 470.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. LARSSON, L. EDSTROM, L. SVENSSON, B. SODERPALM, and J. A. ENGEL
VOLUNTARY ETHANOL INTAKE INCREASES EXTRACELLULAR ACETYLCHOLINE LEVELS IN THE VENTRAL TEGMENTAL AREA IN THE RAT
Alcohol Alcohol.,
September 1, 2005;
40(5):
349 - 358.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Riegel and C. R. Lupica
Independent Presynaptic and Postsynaptic Mechanisms Regulate Endocannabinoid Signaling at Multiple Synapses in the Ventral Tegmental Area
J. Neurosci.,
December 8, 2004;
24(49):
11070 - 11078.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto, B. M. Witkin, A. Zangen, and R. A. Wise
Rewarding Effects of AMPA Administration into the Supramammillary or Posterior Hypothalamic Nuclei But Not the Ventral Tegmental Area
J. Neurosci.,
June 23, 2004;
24(25):
5758 - 5765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Michel, J. M. Robillard, and L.-E. Trudeau
Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors
J. Physiol.,
April 15, 2004;
556(2):
429 - 445.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. A. Yun, K. T. Wakabayashi, H. L. Fields, and S. M. Nicola
The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues
J. Neurosci.,
March 24, 2004;
24(12):
2923 - 2933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Leite-Morris, E. Y. Fukudome, M. H. Shoeb, and G. B. Kaplan
GABAB Receptor Activation in the Ventral Tegmental Area Inhibits the Acquisition and Expression of Opiate-Induced Motor Sensitization
J. Pharmacol. Exp. Ther.,
February 1, 2004;
308(2):
667 - 678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Will, E. B. Franzblau, and A. E. Kelley
Nucleus Accumbens {micro}-Opioids Regulate Intake of a High-Fat Diet via Activation of a Distributed Brain Network
J. Neurosci.,
April 1, 2003;
23(7):
2882 - 2888.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ikemoto and R. A. Wise
Rewarding Effects of the Cholinergic Agents Carbachol and Neostigmine in the Posterior Ventral Tegmental Area
J. Neurosci.,
November 15, 2002;
22(22):
9895 - 9904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Colombo, S. Serra, G. Brunetti, G. Atzori, M. Pani, G. Vacca, G. Addolorato, W. Froestl, M. A. M. Carai, and G. L. Gessa
THE GABAB RECEPTOR AGONISTS BACLOFEN AND CGP 44532 PREVENT ACQUISITION OF ALCOHOL DRINKING BEHAVIOUR IN ALCOHOL-PREFERRING RATS
Alcohol Alcohol.,
September 1, 2002;
37(5):
499 - 503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Georges and G. Aston-Jones
Activation of Ventral Tegmental Area Cells by the Bed Nucleus of the Stria Terminalis: A Novel Excitatory Amino Acid Input to Midbrain Dopamine Neurons
J. Neurosci.,
June 15, 2002;
22(12):
5173 - 5187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Shalev, J. W. Grimm, and Y. Shaham
Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review
Pharmacol. Rev.,
March 1, 2002;
54(1):
1 - 42.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Cornish, M. Nakamura, and P. W. Kalivas
Dopamine-Independent Locomotion Following Blockade of N-Methyl-D-aspartate Receptors in the Ventral Tegmental Area
J. Pharmacol. Exp. Ther.,
July 1, 2001;
298(1):
226 - 233.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. R. Vorel, X. Liu, R. J. Hayes, J. A. Spector, and E. L. Gardner
Relapse to Cocaine-Seeking After Hippocampal Theta Burst Stimulation
Science,
May 11, 2001;
292(5519):
1175 - 1178.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. D. Stanwood, R. P. Artymyshyn, M.-P. Kung, H. F. Kung, I. Lucki, and P. McGonigle
Quantitative Autoradiographic Mapping of Rat Brain Dopamine D3 Binding with [125I]7-OH-PIPAT: Evidence for the Presence of D3 Receptors on Dopaminergic and Nondopaminergic Cell Bodies and Terminals
J. Pharmacol. Exp. Ther.,
December 1, 2000;
295(3):
1223 - 1231.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
G. D. Stanwood, I. Lucki, and P. McGonigle
Differential Regulation of Dopamine D2 and D3 Receptors by Chronic Drug Treatments
J. Pharmacol. Exp. Ther.,
December 1, 2000;
295(3):
1232 - 1240.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. J. Millan, A. Gobert, K. Bervoets, J.-M. Rivet, S. Veiga, and M. Brocco
Induction of Spontaneous Tail-Flicks in Rats by Blockade of Transmission at N-Methyl-D-Aspartate Receptors: Roles of Multiple Monoaminergic Receptors in Relation to the Actions of Antipsychotic Agents
J. Pharmacol. Exp. Ther.,
February 1, 2000;
292(2):
672 - 683.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Z.-B. You, T. M. Tzschentke, E. Brodin, and R. A. Wise
Electrical Stimulation of the Prefrontal Cortex Increases Cholecystokinin, Glutamate, and Dopamine Release in the Nucleus Accumbens: an In Vivo Microdialysis Study in Freely Moving Rats
J. Neurosci.,
August 15, 1998;
18(16):
6492 - 6500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Adams and B. Moghaddam
Corticolimbic Dopamine Neurotransmission Is Temporally Dissociated from the Cognitive and Locomotor Effects of Phencyclidine
J. Neurosci.,
July 15, 1998;
18(14):
5545 - 5554.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.H.C. Westerink, P. Enrico, J. Feimann, and J.B. De Vries
The Pharmacology of Mesocortical Dopamine Neurons: A Dual-Probe Microdialysis Study in the Ventral Tegmental Area and Prefrontal Cortex of the Rat Brain
J. Pharmacol. Exp. Ther.,
April 1, 1998;
285(1):
143 - 154.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
B. Bontempi and F. R. Sharp
Systemic Morphine-Induced Fos Protein in the Rat Striatum and Nucleus Accumbens Is Regulated by µ Opioid Receptors in the Substantia Nigra and Ventral Tegmental Area
J. Neurosci.,
November 1, 1997;
17(21):
8596 - 8612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
