 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 2716-2723, Copyright © 1996 by Society for Neuroscience
Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation
CJ Woolf, QP Ma, A Allchorne and S Poole
Department of Anatomy and Developmental Biology, University College London, United Kingdom.
The contribution of nerve growth factor (NGF) to inflammatory hyperalgesia
potentially could be mediated by any of the three peripheral cell types
that express trkA, the high-affinity NGF receptor: inflammatory cells,
sympathetic neurons, and primary sensory neurons. To investigate their
relative involvement, the effects of sympathectomy and mast cell
degranulation were examined on the local inflammation produced by an
intraplantar injection of complete Freund's adjuvant in the adult rat.
Sympathectomy, produced by neonatal guanethidine treatment, elevated basal
NGF levels in the skin but did not attenuate a further increase in NGF
during inflammation. Although the onset of inflammatory hyperalgesia was
delayed in sympathectomized animals, peak sensitivity was not affected and
was still NGF-dependent. In contrast, mast cell degranulation produced by
several days of treatment with the cationic secretagogue compound 48/80,
while also increasing basal NGF levels, prevented a further increase in NGF
levels and attenuated hypersensitivity during inflammation. Neither
manipulation modified the inflammatory upregulation of interleukin- 1beta.
We conclude that sympathetic neurons contribute transiently to inflammatory
hyperalgesia, but that mast cells and sensory neurons are important sites
for the sustained action of NGF in producing increased sensitivity during
inflammation.
This article has been cited by other articles:
|
|
|
|
 
A. N. Akopian, N. B. Ruparel, A. Patwardhan, and K. M. Hargreaves
Cannabinoids Desensitize Capsaicin and Mustard Oil Responses in Sensory Neurons via TRPA1 Activation
J. Neurosci.,
January 30, 2008;
28(5):
1064 - 1075.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Thacker, A. K. Clark, F. Marchand, and S. B. McMahon
Pathophysiology of Peripheral Neuropathic Pain: Immune Cells and Molecules
Anesth. Analg.,
September 1, 2007;
105(3):
838 - 847.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. D. Nicol and M. R. Vasko
Unraveling the Story of NGF-mediated Sensitization of Nociceptive Sensory Neurons: ON or OFF the Trks?
Mol. Interv.,
February 1, 2007;
7(1):
26 - 41.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Oda, S. Ikari, T. Matsuno, Y. Morimune, M. Nagahama, and J. Sakurai
Signal Transduction Mechanism Involved in Clostridium perfringens Alpha-Toxin-Induced Superoxide Anion Generation in Rabbit Neutrophils.
Infect. Immun.,
May 1, 2006;
74(5):
2876 - 2886.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Lotz and J. A. Ulrich
Innervation, Inflammation, and Hypermobility May Characterize Pathologic Disc Degeneration: Review of Animal Model Data
J. Bone Joint Surg. Am.,
April 1, 2006;
88(suppl_2):
76 - 82.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Obata, H. Yamanaka, Y. Dai, T. Tachibana, T. Fukuoka, A. Tokunaga, H. Yoshikawa, and K. Noguchi
Differential Activation of Extracellular Signal-Regulated Protein Kinase in Primary Afferent Neurons Regulates Brain-Derived Neurotrophic Factor Expression after Peripheral Inflammation and Nerve Injury
J. Neurosci.,
May 15, 2003;
23(10):
4117 - 4126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Afonso, E. R. Tulman, Z. Lu, L. Zsak, G. F. Kutish, and D. L. Rock
The Genome of Fowlpox Virus
J. Virol.,
April 15, 2000;
74(8):
3815 - 3831.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. J. Mannion, M. Costigan, I. Decosterd, F. Amaya, Q.-P. Ma, J. C. Holstege, R.-R. Ji, A. Acheson, R. M. Lindsay, G. A. Wilkinson, et al.
Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity
PNAS,
August 3, 1999;
96(16):
9385 - 9390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. G. Murphy, L. S. Borthwick, R. S. Johnston, G. Kuchel, and P. M. Richardson
Nature of the Retrograde Signal from Injured Nerves that Induces Interleukin-6 mRNA in Neurons
J. Neurosci.,
May 15, 1999;
19(10):
3791 - 3800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. de VRIES, M. C. DESSING, F. ENGELS, P. A. J. HENRICKS, and F. P. NIJKAMP
Nerve Growth Factor Induces a Neurokinin-1 Receptor- Mediated Airway Hyperresponsiveness in Guinea Pigs
Am. J. Respir. Crit. Care Med.,
May 1, 1999;
159(5):
1541 - 1544.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Fjell, T. R. Cummins, K. Fried, J. A. Black, and S. G. Waxman
In Vivo NGF Deprivation Reduces SNS Expression and TTX-R Sodium Currents in IB4-Negative DRG Neurons
J Neurophysiol,
February 1, 1999;
81(2):
803 - 810.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Zhou, Q. Zhang, C. Stein, and M. Schäfer
Contribution of Opioid Receptors on Primary Afferent Versus Sympathetic Neurons to Peripheral Opioid Analgesia
J. Pharmacol. Exp. Ther.,
August 1, 1998;
286(2):
1000 - 1006.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Costigan, R. J. Mannion, G. Kendall, S. E. Lewis, J. A. Campagna, R. E. Coggeshall, J. Meridith-Middleton, S. Tate, and C. J. Woolf
Heat Shock Protein 27: Developmental Regulation and Expression after Peripheral Nerve Injury
J. Neurosci.,
August 1, 1998;
18(15):
5891 - 5900.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. R. Banner, P. H. Patterson, A. Allchorne, S. Poole, and C. J. Woolf
Leukemia Inhibitory Factor Is an Anti-Inflammatory and Analgesic Cytokine
J. Neurosci.,
July 15, 1998;
18(14):
5456 - 5462.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Calza, L. Giardino, M. Pozza, A. Micera, and L. Aloe
Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis
PNAS,
April 1, 1997;
94(7):
3368 - 3373.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Frick, D. L. Price, V. E. Koliatsos, and A. L. Markowska
The Effects of Nerve Growth Factor on Spatial Recent Memory in Aged Rats Persist after Discontinuation of Treatment
J. Neurosci.,
April 1, 1997;
17(7):
2543 - 2550.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Steiner, G. S. Hamilton, D. T. Ross, H. L. Valentine, H. Guo, M. A. Connolly, S. Liang, C. Ramsey, J.-H. J. Li, W. Huang, et al.
Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
PNAS,
March 4, 1997;
94(5):
2019 - 2024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R.-R. Ji and F. Rupp
Phosphorylation of Transcription Factor CREB in Rat Spinal Cord after Formalin-Induced Hyperalgesia: Relationship to c-fos Induction
J. Neurosci.,
March 1, 1997;
17(5):
1776 - 1785.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
.gif?ad=17923&adview=true)
