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Journal of Neuroscience, Vol 16, 2724-2739, Copyright © 1996 by Society for Neuroscience
Contributions of individual layer 6 pyramidal neurons to local circuitry in macaque primary visual cortex
AK Wiser and EM Callaway
Department of physiology, University of Colorado School of Medicine, Denver, Colorado 80262, USA.
We have studied the contributions of individual layer 6 pyramidal neurons
in macaque primary visual cortex to local cortical circuitry by
intracellular labeling and analysis of the morphologies of 58 neurons.
These neurons are separated based on the laminar specificity of axonal and
dendritic arbors into two classes, class I and class II, and into several
types within these classes. Class I neurons project axons heavily and
predominantly to layer 4C, whereas class II neurons have axonal projections
primarily to layers other than 4C. Only 16 of the 58 neurons in our sample
(28 percent) project to the white matter. Class I projection neurons are
found at the top and bottom of layer 6, suggesting that they project to the
lateral geniculate nucleus, whereas class II projection neurons are located
in the middle of layer 6, suggesting that they project to the claustrum.
The different types of class I neurons are distinguished from one another
based on the sublaminar specificity of their axonal and dendritic arbors
within layer 4, where they are biased toward compartments dominated by
input from different functional streams. They are also distinct in their
distributions within the depth of layer 6. The distinctive characteristics
of the neuronal types we have identified suggest that each receives input
from different sources and projects to a set of targets that is
functionally appropriate. Thus, each type is likely to contribute uniquely
to computations within V1 and extrinsically.
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