 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 16, 2767-2779, Copyright © 1996 by Society for Neuroscience
Spatiotemporal properties of short-term plasticity sensorimotor thalamocortical pathways of the rat
MA Castro-Alamancos and BW Connors
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.
Each region of neocortex receives synaptic input from several thalamic
nuclei, but the response properties of thalamocortical pathways may differ.
We have studied the frontoparietal (motor and somatosensory) neocortex of
the rat and have examined the responses induced by stimulating two
convergent thalamocortical projections originating in the ventrolateral
(VL) nucleus and ventroposterior lateral (VPL) nucleus. Depth recordings
and current-source density (CSD) analysis revealed two primary responses
with different laminar and temporal patterns when VL and VPL were
stimulated. Single shocks to VL produced a characteristic small current
sink in layer V, which strongly enhanced in response to a second pulse
delivered within a 50-200 msec interval (i.e., the augmenting response). In
contrast, a shock to VPL evoked a large current sink that originated in
layer IV, spread strongly into the supragranular layers, and was almost
abolished in response to a second pulse at intervals of <200 msec (i.e.,
the decremental response). Control experiments determined that these
responses could not be attributed to the antidromic firing of
corticothalamic cells, intrathalamic mechanisms, or anesthesia. Topographic
response maps were obtained from a grid of 30 sites across frontoparietal
cortex. One shock to VL excited a very limited cortical region, but an
augmenting response evoked 50-200 msec later spread at approximately 1
m/sec to synchronize the activity across an area up to 25 times larger. In
contrast, a single shock to VPL activated a relatively large area, but the
area activated by a second shock delivered within 200 msec was much
smaller. We conclude that overlapping thalamocortical projections,
originating in different thalamic nuclei, have distinct spatiotemporal
response characteristics that may serve the functional specializations of
these pathways.
This article has been cited by other articles:
|
|
|
|
 
S. R. Jones, D. L. Pritchett, S. M. Stufflebeam, M. Hamalainen, and C. I. Moore
Neural Correlates of Tactile Detection: A Combined Magnetoencephalography and Biophysically Based Computational Modeling Study
J. Neurosci.,
October 3, 2007;
27(40):
10751 - 10764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Quairiaux, M. Armstrong-James, and E. Welker
Modified Sensory Processing in the Barrel Cortex of the Adult Mouse After Chronic Whisker Stimulation
J Neurophysiol,
March 1, 2007;
97(3):
2130 - 2147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Iremonger, T. R. Anderson, B. Hu, and Z. H. T. Kiss
Cellular Mechanisms Preventing Sustained Activation of Cortex During Subcortical High-Frequency Stimulation
J Neurophysiol,
August 1, 2006;
96(2):
613 - 621.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Reig, R. Gallego, L. G. Nowak, and M. V. Sanchez-Vives
Impact of Cortical Network Activity on Short-term Synaptic Depression
Cereb Cortex,
May 1, 2006;
16(5):
688 - 695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hirata and M. A. Castro-Alamancos
Relief of Synaptic Depression Produces Long-Term Enhancement in Thalamocortical Networks
J Neurophysiol,
April 1, 2006;
95(4):
2479 - 2491.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Bereshpolova, C. R. Stoelzel, A. G. Gusev, T. Bezdudnaya, and H. A. Swadlow
The impact of a corticotectal impulse on the awake superior colliculus.
J. Neurosci.,
February 22, 2006;
26(8):
2250 - 2259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gervasoni, S.-C. Lin, S. Ribeiro, E. S. Soares, J. Pantoja, and M. A. L. Nicolelis
Global Forebrain Dynamics Predict Rat Behavioral States and Their Transitions
J. Neurosci.,
December 8, 2004;
24(49):
11137 - 11147.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Reichova and S. M. Sherman
Somatosensory Corticothalamic Projections: Distinguishing Drivers From Modulators
J Neurophysiol,
October 1, 2004;
92(4):
2185 - 2197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ganguly and D. Kleinfeld
Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
PNAS,
August 17, 2004;
101(33):
12348 - 12353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Werk and C. A. Chapman
Long-term Potentiation of Polysynaptic Responses in Layer V of the Sensorimotor Cortex Induced by Theta-patterned Tetanization in the Awake Rat
Cereb Cortex,
May 1, 2003;
13(5):
500 - 507.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Dauper, T. Peschel, C. Schrader, C. Kohlmetz, G. Joppich, W. Nager, R. Dengler, and J. D. Rollnik
Effects of subthalamic nucleus (STN) stimulation on motor cortex excitability
Neurology,
September 10, 2002;
59(5):
700 - 706.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. A. Swadlow, A. G. Gusev, and T. Bezdudnaya
Activation of a Cortical Column by a Thalamocortical Impulse
J. Neurosci.,
September 1, 2002;
22(17):
7766 - 7773.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. K. M. Meeren, J. P. M. Pijn, E. L. J. M. Van Luijtelaar, A. M. L. Coenen, and F. H. Lopes da Silva
Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats
J. Neurosci.,
February 15, 2002;
22(4):
1480 - 1495.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Steriade
Impact of Network Activities on Neuronal Properties in Corticothalamic Systems
J Neurophysiol,
July 1, 2001;
86(1):
1 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Ego-Stengel, D. E. Shulz, S. Haidarliu, R. Sosnik, and E. Ahissar
Acetylcholine-Dependent Induction and Expression of Functional Plasticity in the Barrel Cortex of the Adult Rat
J Neurophysiol,
July 1, 2001;
86(1):
422 - 437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Castro-Alamancos
Origin of Synchronized Oscillations Induced by Neocortical Disinhibition In Vivo
J. Neurosci.,
December 15, 2000;
20(24):
9195 - 9206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. E. Fanselow and M. A. L. Nicolelis
Behavioral Modulation of Tactile Responses in the Rat Somatosensory System
J. Neurosci.,
September 1, 1999;
19(17):
7603 - 7616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Reinagel, D. Godwin, S. M. Sherman, and C. Koch
Encoding of Visual Information by LGN Bursts
J Neurophysiol,
May 1, 1999;
81(5):
2558 - 2569.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Steriade, I. Timofeev, F. Grenier, and N. Durmuller
Role of Thalamic and Cortical Neurons in Augmenting Responses and Self-Sustained Activity: Dual Intracellular Recordings In Vivo
J. Neurosci.,
August 15, 1998;
18(16):
6425 - 6443.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Computational Models of Thalamocortical Augmenting Responses
J. Neurosci.,
August 15, 1998;
18(16):
6444 - 6465.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. S. Chance, S. B. Nelson, and L. F. Abbott
Synaptic Depression and the Temporal Response Characteristics of V1 Cells
J. Neurosci.,
June 15, 1998;
18(12):
4785 - 4799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Timofeev and M. Steriade
Cellular Mechanisms Underlying Intrathalamic Augmenting Responses of Reticular and Relay Neurons
J Neurophysiol,
May 1, 1998;
79(5):
2716 - 2729.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Cellular and Network Models for Intrathalamic Augmenting Responses During 10-Hz Stimulation
J Neurophysiol,
May 1, 1998;
79(5):
2730 - 2748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Buzsaki and A. Kandel
Somadendritic Backpropagation of Action Potentials in Cortical Pyramidal Cells of the Awake Rat
J Neurophysiol,
March 1, 1998;
79(3):
1587 - 1591.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Varela, K. Sen, J. Gibson, J. Fost, L. F. Abbott, and S. B. Nelson
A Quantitative Description of Short-Term Plasticity at Excitatory Synapses in Layer 2/3 of Rat Primary Visual Cortex
J. Neurosci.,
October 15, 1997;
17(20):
7926 - 7940.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kandel and G. Buzsaki
Cellular-Synaptic Generation of Sleep Spindles, Spike-and-Wave Discharges, and Evoked Thalamocortical Responses in the Neocortex of the Rat
J. Neurosci.,
September 1, 1997;
17(17):
6783 - 6797.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Steriade and I. Timofeev
Short-Term Plasticity during Intrathalamic Augmenting Responses in Decorticated Cats
J. Neurosci.,
May 15, 1997;
17(10):
3778 - 3795.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Castro-Alamancos and B. W. Connors
Cellular Mechanisms of the Augmenting Response: Short-Term Plasticity in a Thalamocortical Pathway
J. Neurosci.,
December 1, 1996;
16(23):
7742 - 7756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
