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Volume 17, Number 1,
Issue of January 1, 1997
pp. 204-215
Copyright ©1997 Society for Neuroscience
Functional Properties of AMPA and NMDA Receptors Expressed in
Identified Types of Basal Ganglia Neurons
Received July 22, 1996; revised Oct. 7, 1996; accepted Oct. 17, 1996.
Thomas Götz1,
Udo Kraushaar1, 3,
Jörg Geiger1, 3,
Joachim Lübke2,
Thomas Berger1, and
Peter Jonas1
1 Physiologisches Institut der Universität
Freiburg, 2 Anatomisches Institut der Universität
Freiburg, and 3 Institut für Biologie III der
Universität Freiburg, 79104 Freiburg, Germany
AMPA- and NMDA-type glutamate receptors (AMPARs and NMDARs) mediate
excitatory synaptic transmission in the basal ganglia and may
contribute to excitotoxic injury. We investigated the functional
properties of AMPARs and NMDARs expressed by six main types of basal
ganglia neurons in acute rat brain slices (principal neurons and
cholinergic interneurons of striatum, GABAergic and dopaminergic
neurons of substantia nigra, globus pallidus neurons, and subthalamic
nucleus neurons) using fast application of glutamate to nucleated and
outside-out membrane patches. AMPARs in different types of basal
ganglia neurons were functionally distinct. Those expressed in striatal
principal neurons exhibited the slowest gating (desensitization time
constant  = 11.5 msec, 1 mM glutamate, 22°C), whereas
those in striatal cholinergic interneurons showed the fastest gating
(desensitization time constant = 3.6 msec). The lowest
Ca2+ permeability of AMPARs was observed in nigral
dopaminergic neurons (PCa/PNa = 0.10), whereas the highest Ca2+ permeability was found in
subthalamic nucleus neurons
(PCa/PNa = 1.17). NMDARs of different types of basal ganglia neurons were less
variable in their functional properties; those expressed in nigral
dopaminergic neurons exhibited the slowest gating (deactivation time
constant of predominant fast component 1 = 150 msec, 100 µM glutamate), and those of globus pallidus neurons
showed the fastest gating (1 = 67 msec). The
Mg2+ block of NMDARs was similar; the average chord
conductance ratio g 60mV/g+40mV
was 0.18-0.22 in 100 µM external Mg2+.
Hence, AMPARs expressed in different types of basal ganglia neurons are
markedly diverse, whereas NMDARs are less variable in functional
properties that are relevant for excitatory synaptic transmission and
neuronal vulnerability.
Key words:
AMPA receptors;
NMDA receptors;
deactivation;
desensitization;
Ca2+ permeability;
Mg2+ block;
basal ganglia neurons;
fast application;
glutamate
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