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Volume 17, Number 1, Issue of January 1, 1997 pp. 277-295
Copyright ©1997 Society for NeuroscienceMaturation of Neuronal Form and Function in a Mouse Thalamo-Cortical Circuit
Received July 7, 1996; revised Oct. 10, 1996; accepted Oct. 14, 1996.
Richard A. Warren and Edward G. Jones Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, and Neural Systems Laboratory, Frontier Research Program in Brain Mechanisms of Mind and Behavior, The Institute for Physical and Chemical Research, Wako, Saitama 351-01, Japan
Postnatal development of physiological properties underlying slow intrathalamic oscillations was studied by whole-cell recording from synaptically coupled neurons of the reticular nucleus (RTN) and ventral posterior nucleus (VPN) of mouse brain slices in vitro and compared with the morphological development of dye-injected cells. Between postnatal days 3 and 11 (P3-P11), progressive changes in RTN and VPN neurons included shortening of the membrane time constant, decreasing input resistance, and lowering of the resting membrane potential (RMP). Low-threshold Ca2+ spikes (LTS) were present from P3, but their capacity to sustain multispike bursts was limited before P11. Synaptic responses were evoked in RTN and VPN neurons by electrical stimulation of the internal capsule from P3. Younger RTN neurons responded with a single spike, but their capacity to fire bursts gradually improved as the RMP reached levels below the LTS activation potential. Concomitantly, as the reversal potential of the inhibitory postsynaptic potential in VPN neurons became more negative, its capacity to deinactivate the LTS increased, and rebound bursts that could maintain oscillations were produced; sustained oscillations became the typical response to internal capsule stimulation at P12. The functional maturation of the intrathalamic circuitry, particularly between P10 and P14, occurs in parallel with the morphological maturation (size, dendritic growth, and dendritic field structure) of individual RTN and VPN neurons, as studied by confocal microscopy. Maturation of RTN cells led that of VPN cells by 2-3 d. The appearance of intrathalamic oscillations is probably correlated with the appearance of slow-wave sleep in postnatal animals.
Key words: reticular nucleus; ventral posterior nucleus; whole-cell recording; oscillations; injected cells; sleep
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