 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 17, Number 1, Issue of January 1, 1997 pp. 438-458
Copyright ©1997 Society for NeuroscienceAnatomic Organization of the Basilar Pontine Projections from Prefrontal Cortices in Rhesus Monkey
Received July 12, 1996; revised Oct. 10, 1996; accepted Oct. 16, 1996.
Jeremy D. Schmahmann1 and Deepak N. Pandya2 1 Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, and 2 Harvard Neurological Unit, Beth Israel Hospital, Boston, Massachusetts 02114, and Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02114
In our ongoing attempt to determine the anatomic substrates that could support a cerebellar contribution to cognitive processing, we investigated the prefrontal cortical projections to the basilar pons. A detailed understanding of these pathways is needed, because the prefrontal cortex is critical for a number of complex cognitive operations, and the corticopontine projection is the obligatory first step in the corticopontocerebellar circuit. Prefrontopontine connections were studied using the autoradiographic technique in rhesus monkey. The pontine projections were most prominent and occupied the greatest rostrocaudal extent of the pons when derived from the dorsolateral prefrontal convexity, including areas 8Ad, 9/46d, and 10. Lesser pontine projections were observed from the medial prefrontal convexity and area 45B in the inferior limb of the arcuate sulcus. In contrast, ventral prefrontal and orbitofrontal cortices did not demonstrate pontine projections. The prefrontopontine terminations were located preferentially in the paramedian nucleus and in the medial parts of the peripeduncular nucleus, but each cortical area appeared to have a unique complement of pontine nuclei with which it is connected. The existence of these corticopontine pathways from prefrontal areas concerned with multiple domains of higher-order processing is consistent with the hypothesis that the cerebellum is an essential node in the distributed corticosubcortical neural circuits subserving cognitive operations.
Key words: frontal lobe; pons; cerebellum; connections; anatomy; behavior; cognition
This article has been cited by other articles:
F. M. Krienen and R. L. Buckner
Segregated Fronto-Cerebellar Circuits Revealed by Intrinsic Functional Connectivity
Cereb Cortex, October 1, 2009; 19(10): 2485 - 2497.
[Abstract] [Full Text] [PDF]
J. X. O'Reilly, C. F. Beckmann, V. Tomassini, N. Ramnani, and H. Johansen-Berg
Distinct and Overlapping Functional Zones in the Cerebellum Defined by Resting State Functional Connectivity
Cereb Cortex, August 14, 2009; (2009) bhp157v1.
[Abstract] [Full Text] [PDF]
B. E. Kalmbach, T. Ohyama, J. C. Kreider, F. Riusech, and M. D. Mauk
Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning
Learn. Mem., January 7, 2009; 16(1): 86 - 95.
[Abstract] [Full Text] [PDF]
J. Parker, A. Mitchell, A. Kalpakidou, M. Walshe, H.-Y. Jung, C. Nosarti, P. Santosh, L. Rifkin, J. Wyatt, R. M. Murray, et al.
Cerebellar growth and behavioural & neuropsychological outcome in preterm adolescents
Brain, May 1, 2008; 131(5): 1344 - 1351.
[Abstract] [Full Text] [PDF]
J. Tanji and E. Hoshi
Role of the Lateral Prefrontal Cortex in Executive Behavioral Control
Physiol Rev, January 1, 2008; 88(1): 37 - 57.
[Abstract] [Full Text] [PDF]
M. Petrides and D. N. Pandya
Efferent Association Pathways from the Rostral Prefrontal Cortex in the Macaque Monkey
J. Neurosci., October 24, 2007; 27(43): 11573 - 11586.
[Abstract] [Full Text] [PDF]
Y. Moriguchi, J. Decety, T. Ohnishi, M. Maeda, T. Mori, K. Nemoto, H. Matsuda, and G. Komaki
Empathy and Judging Other's Pain: An fMRI Study of Alexithymia
Cereb Cortex, September 1, 2007; 17(9): 2223 - 2234.
[Abstract] [Full Text] [PDF]
G.K. Spanos, E.A. Wilde, E.D. Bigler, H.B. Cleavinger, M.A. Fearing, H.S. Levin, X. Li, and J.V. Hunter
Cerebellar Atrophy after Moderate-to-Severe Pediatric Traumatic Brain Injury
AJNR Am. J. Neuroradiol., March 1, 2007; 28(3): 537 - 542.
[Abstract] [Full Text] [PDF]
M.-C. Huang, S.-M. Wang, Y.-W. Hsu, H.-C. Lin, C.-Y. Chi, and C.-C. Liu
Long-term Cognitive and Motor Deficits After Enterovirus 71 Brainstem Encephalitis in Children
Pediatrics, December 1, 2006; 118(6): e1785 - e1788.
[Abstract] [Full Text] [PDF]
K. Lasek, R. Lencer, C. Gaser, J. Hagenah, U. Walter, A. Wolters, N. Kock, S. Steinlechner, M. Nagel, C. Zuhlke, et al.
Morphological basis for the spectrum of clinical deficits in spinocerebellar ataxia 17 (SCA17)
Brain, September 1, 2006; 129(9): 2341 - 2352.
[Abstract] [Full Text] [PDF]
N. Ramnani, T. E.J. Behrens, H. Johansen-Berg, M. C. Richter, M. A. Pinsk, J. L.R. Andersson, P. Rudebeck, O. Ciccarelli, W. Richter, A. J. Thompson, et al.
The Evolution of Prefrontal Inputs to the Cortico-pontine System: Diffusion Imaging Evidence from Macaque Monkeys and Humans
Cereb Cortex, June 1, 2006; 16(6): 811 - 818.
[Abstract] [Full Text] [PDF]
K. H. Taber, P. L. Strick, and R. A. Hurley
Rabies and the Cerebellum: New Methods for Tracing Circuits in the Brain
J Neuropsychiatry Clin Neurosci, May 1, 2005; 17(2): 133 - 139.
[Full Text] [PDF]
I. Tanibuchi and P. S. Goldman-Rakic
Comparison of Oculomotor Neuronal Activity in Paralaminar and Mediodorsal Thalamus in the Rhesus Monkey
J Neurophysiol, January 1, 2005; 93(1): 614 - 619.
[Abstract] [Full Text] [PDF]
R. Hester and H. Garavan
Executive Dysfunction in Cocaine Addiction: Evidence for Discordant Frontal, Cingulate, and Cerebellar Activity
J. Neurosci., December 8, 2004; 24(49): 11017 - 11022.
[Abstract] [Full Text] [PDF]
M. Eckert
Neuroanatomical Markers for Dyslexia: A Review of Dyslexia Structural Imaging Studies
Neuroscientist, August 1, 2004; 10(4): 362 - 371.
[Abstract] [PDF]
J. D. Schmahmann
Disorders of the Cerebellum: Ataxia, Dysmetria of Thought, and the Cerebellar Cognitive Affective Syndrome
J Neuropsychiatry Clin Neurosci, August 1, 2004; 16(3): 367 - 378.
[Abstract] [Full Text] [PDF]
E. Hoshi and J. Tanji
Area-Selective Neuronal Activity in the Dorsolateral Prefrontal Cortex for Information Retrieval and Action Planning
J Neurophysiol, June 1, 2004; 91(6): 2707 - 2722.
[Abstract] [Full Text] [PDF]
J. D. Schmahmann, R. Ko, and J. MacMore
The human basis pontis: motor syndromes and topographic organization
Brain, June 1, 2004; 127(6): 1269 - 1291.
[Abstract] [Full Text] [PDF]
B. Greger, S. A. Norris, and W. T. Thach
Spike Firing in the Lateral Cerebellar Cortex Correlated With Movement and Motor Parameters Irrespective of the Effector Limb
J Neurophysiol, January 1, 2004; 91(1): 576 - 582.
[Abstract] [Full Text]
R. M. Kelly and P. L. Strick
Cerebellar Loops with Motor Cortex and Prefrontal Cortex of a Nonhuman Primate
J. Neurosci., September 10, 2003; 23(23): 8432 - 8444.
[Abstract] [Full Text] [PDF]
M. Steinlin, S. Imfeld, P. Zulauf, E. Boltshauser, K.-O. Lovblad, A. R. Luthy, W. Perrig, and F. Kaufmann
Neuropsychological long-term sequelae after posterior fossa tumour resection during childhood
Brain, September 1, 2003; 126(9): 1998 - 2008.
[Abstract] [Full Text] [PDF]
E. V. Sullivan, M. J. Rosenbloom, K. L. Serventi, A. Deshmukh, and A. Pfefferbaum
Effects of Alcohol Dependence Comorbidity and Antipsychotic Medication on Volumes of the Thalamus and Pons in Schizophrenia
Am J Psychiatry, June 1, 2003; 160(6): 1110 - 1116.
[Abstract] [Full Text] [PDF]
M. A. Eckert, C. M. Leonard, T. L. Richards, E. H. Aylward, J. Thomson, and V. W. Berninger
Anatomical correlates of dyslexia: frontal and cerebellar findings
Brain, February 1, 2003; 126(2): 482 - 494.
[Abstract] [Full Text] [PDF]
A. Bischoff-Grethe, R. B. Ivry, and S. T. Grafton
Cerebellar Involvement in Response Reassignment Rather Than Attention
J. Neurosci., January 15, 2002; 22(2): 546 - 553.
[Abstract] [Full Text] [PDF]
J. Parvizi, S. W. Anderson, C. O. Martin, H. Damasio, and A. R. Damasio
Pathological laughter and crying: A link to the cerebellum
Brain, September 1, 2001; 124(9): 1708 - 1719.
[Abstract] [Full Text] [PDF]
F. A. Middleton and P. L. Strick
Cerebellar Projections to the Prefrontal Cortex of the Primate
J. Neurosci., January 15, 2001; 21(2): 700 - 712.
[Abstract] [Full Text] [PDF]
D. Riva and C. Giorgi
The cerebellum contributes to higher functions during development: Evidence from a series of children surgically treated for posterior fossa tumours
Brain, May 1, 2000; 123(5): 1051 - 1061.
[Abstract] [Full Text] [PDF]
R. A. Carper and E. Courchesne
Inverse correlation between frontal lobe and cerebellum sizes in children with autism
Brain, April 1, 2000; 123(4): 836 - 844.
[Abstract] [Full Text] [PDF]
K. Burk, C. Globas, S. Bosch, S. Graber, M. Abele, A. Brice, J. Dichgans, I. Daum, and T. Klockgether
Cognitive deficits in spinocerebellar ataxia 2
Brain, April 1, 1999; 122(4): 769 - 777.
[Abstract] [Full Text] [PDF]
J. E. Desmond, J. D. E. Gabrieli, A. D. Wagner, B. L. Ginier, and G. H. Glover
Lobular Patterns of Cerebellar Activation in Verbal Working-Memory and Finger-Tapping Tasks as Revealed by Functional MRI
J. Neurosci., December 15, 1997; 17(24): 9675 - 9685.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|