WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (87)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roeper, J.
Right arrow Articles by Pongs, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roeper, J.
Right arrow Articles by Pongs, O.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*CALCIUM COMPOUNDS
*CALCIUM, ELEMENTAL
*POTASSIUM

Next Article 

Volume 17, Number 10, Issue of May 15, 1997 pp. 3379-3391
Copyright ©1997 Society for Neuroscience

Frequency-Dependent Inactivation of Mammalian A-Type K+ Channel KV1.4 Regulated by Ca2+/Calmodulin-Dependent Protein Kinase

Received Aug. 10, 1996; revised Feb. 18, 1997; accepted Feb. 24, 1997.

Jochen Roeper, Christoph Lorra, and Olaf Pongs

Zentrum für Molekulare Neurobiologie, Martinistrasse 52, D-20246 Hamburg, Germany

Ca2+/calmodulin dependent protein kinase (CaMKII) and protein phosphatase 2B (calcineurin) are key enzymes in the regulation of synaptic strength, controlling the phosphorylation status of pre- and postsynaptic target proteins. Here, we show that the inactivation gating of the Shaker-related fast-inactivating KV channel, Kv1.4 is controlled by CaMKII and the calcineurin/inhibitor-1 protein phosphatase cascade. CaMKII phosphorylation of an amino-terminal residue of KV1.4 leads to slowing of inactivation gating and accelerated recovery from N-type inactivated states. In contrast, dephosphorylation of this residue induces a fast inactivating mode of KV1.4 with time constants of inactivation 5 to 10 times faster compared with the CaMKII-phosphorylated form. Dephosphorylated KV1.4 channels also display slowed and partial recovery from inactivation with increased trapping of KV1.4 channels in long-absorbing C-type inactivated states. In consequence, dephosphorylated KV1.4 displays a markedly increased tendency to undergo cumulative inactivation during repetitive stimulation. The balance between phosphorylated and dephosphorylated KV1.4 channels is regulated by changes in intracellular Ca2+ concentration rendering KV1.4 inactivation gating Ca2+-sensitive. The reciprocal CaMKII and calcineurin regulation of cumulative inactivation of presynaptic KV1.4 may provide a novel mechanism to regulate the critical frequency for presynaptic spike broadening and induction of synaptic plasticity.

Key words: voltage-activated K channels; Shaker; N-type inactivation; C-type inactivation; phosphorylation; CaMKII; calcineurin; protein phosphatase; synapse




This article has been cited by other articles:


Home page
 Circ Arrhythm ElectrophysiolHome page
S. Wagner, E. Hacker, E. Grandi, S. L. Weber, N. Dybkova, S. Sossalla, T. Sowa, L. Fabritz, P. Kirchhof, D. M. Bers, et al.
Ca/Calmodulin Kinase II Differentially Modulates Potassium Currents
Circ Arrhythm Electrophysiol, June 1, 2009; 2(3): 285 - 294.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
P. Lirk, M. Poroli, M. Rigaud, A. Fuchs, P. Fillip, C.-Y. Huang, M. Ljubkovic, D. Sapunar, and Q. Hogan
Modulators of Calcium Influx Regulate Membrane Excitability in Rat Dorsal Root Ganglion Neurons
Anesth. Analg., August 1, 2008; 107(2): 673 - 685.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
A. R. Brennan, B. Dolinsky, M.-A. T. Vu, M. Stanley, M. F. Yeckel, and A. F.T. Arnsten
Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory
Learn. Mem., February 19, 2008; 15(3): 93 - 96.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
K.-S. Park, J.-W. Yang, E. Seikel, and J. S. Trimmer
Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels
Physiology, February 1, 2008; 23(1): 49 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
R. S. Vest, K. D. Davies, H. O'Leary, J. D. Port, and K. U. Bayer
Dual Mechanism of a Natural CaMKII Inhibitor
Mol. Biol. Cell, December 1, 2007; 18(12): 5024 - 5033.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
P. K. Dash, A. N. Moore, N. Kobori, and J. D. Runyan
Molecular activity underlying working memory
Learn. Mem., August 9, 2007; 14(8): 554 - 563.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. E. D. J. ter Keurs and P. A. Boyden
Calcium and Arrhythmogenesis
Physiol Rev, April 1, 2007; 87(2): 457 - 506.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Chen, J. D. Bohanick, M. Nishihara, J. K. Seamans, and C. R. Yang
Dopamine D1/5 Receptor-Mediated Long-Term Potentiation of Intrinsic Excitability in Rat Prefrontal Cortical Neurons: Ca2+-Dependent Intracellular Signaling
J Neurophysiol, March 1, 2007; 97(3): 2448 - 2464.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
O. Colinas, M. Gallego, R. Setien, J. R. Lopez-Lopez, M. T. Perez-Garcia, and O. Casis
Differential modulation of Kv4.2 and Kv4.3 channels by calmodulin-dependent protein kinase II in rat cardiac myocytes
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1978 - H1987.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. A.G. van der Heyden, T. J.M. Wijnhoven, and T. Opthof
Molecular aspects of adrenergic modulation of the transient outward current
Cardiovasc Res, August 1, 2006; 71(3): 430 - 442.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Ueda and C.-F. Wu
Distinct frequency-dependent regulation of nerve terminal excitability and synaptic transmission by IA and IK potassium channels revealed by Drosophila Shaker and Shab mutations.
J. Neurosci., June 7, 2006; 26(23): 6238 - 6248.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Rezazadeh, T. W. Claydon, and D. Fedida
KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor, Is a Direct Extracellular Blocker of Voltage-Gated Potassium Channels
J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 292 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. P. Patel and D. L. Campbell
Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms
J. Physiol., November 15, 2005; 569(1): 7 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-J. Kim, W. S. Choi, J. S. M. Han, G. Warnock, D. Fedida, and C. H. S. McIntosh
A Novel Mechanism for the Suppression of a Voltage-gated Potassium Channel by Glucose-dependent Insulinotropic Polypeptide: PROTEIN KINASE A-DEPENDENT ENDOCYTOSIS
J. Biol. Chem., August 5, 2005; 280(31): 28692 - 28700.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
J. D. Runyan, A. N. Moore, and P. K. Dash
A role for prefrontal calcium-sensitive protein phosphatase and kinase activities in working memory
Learn. Mem., March 1, 2005; 12(2): 103 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. P. Sergeant, S. Ohya, J. A. Reihill, B. A. Perrino, G. C. Amberg, Y. Imaizumi, B. Horowitz, K. M. Sanders, and S. D. Koh
Regulation of Kv4.3 currents by Ca2+/calmodulin-dependent protein kinase II
Am J Physiol Cell Physiol, February 1, 2005; 288(2): C304 - C313.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. W. Varga, L.-L. Yuan, A. E. Anderson, L. A. Schrader, G.-Y. Wu, J. R. Gatchel, D. Johnston, and J. D. Sweatt
Calcium-Calmodulin-Dependent Kinase II Modulates Kv4.2 Channel Expression and Upregulates Neuronal A-Type Potassium Currents
J. Neurosci., April 7, 2004; 24(14): 3643 - 3654.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. X. Sun, J. J. L. Hodge, Y. Zhou, M. Nguyen, and L. C. Griffith
The eag Potassium Channel Binds and Locally Activates Calcium/Calmodulin-dependent Protein Kinase II
J. Biol. Chem., March 12, 2004; 279(11): 10206 - 10214.
[Abstract] [Full Text] [PDF]

Home page
 J Exp BotHome page
I. Cherel
Regulation of K+ channel activities in plants: from physiological to molecular aspects
J. Exp. Bot., February 1, 2004; 55(396): 337 - 351.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. R. Fernandez, E. Morales, A. J. Rashid, R. J. Dunn, and R. W. Turner
Inactivation of Kv3.3 Potassium Channels in Heterologous Expression Systems
J. Biol. Chem., October 17, 2003; 278(42): 40890 - 40898.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. N. Nitabach, D. A. Llamas, I. J. Thompson, K. A. Collins, and T. C. Holmes
Phosphorylation-Dependent and Phosphorylation-Independent Modes of Modulation of Shaker Family Voltage-Gated Potassium Channels by Src Family Protein Tyrosine Kinases
J. Neurosci., September 15, 2002; 22(18): 7913 - 7922.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Balla, B. Hoch, P. Karczewski, and I. E. Blasig
Calcium/Calmodulin-dependent Protein Kinase IIdelta 2 and gamma Isoforms Regulate Potassium Currents of Rat Brain Capillary Endothelial Cells under Hypoxic Conditions
J. Biol. Chem., June 7, 2002; 277(24): 21306 - 21314.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Hu, L.-R. Shao, S. Chavoshy, N. Gu, M. Trieb, R. Behrens, P. Laake, O. Pongs, H. G. Knaus, O. P. Ottersen, et al.
Presynaptic Ca2+-Activated K+ Channels in Glutamatergic Hippocampal Terminals and Their Role in Spike Repolarization and Regulation of Transmitter Release
J. Neurosci., December 15, 2001; 21(24): 9585 - 9597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. C. Amberg, S. D. Koh, B. A. Perrino, W. J. Hatton, and K. M. Sanders
Regulation of A-type potassium channels in murine colonic myocytes by phosphatase activity
Am J Physiol Cell Physiol, December 1, 2001; 281(6): C2020 - C2028.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Malin and J. M. Nerbonne
Molecular Heterogeneity of the Voltage-Gated Fast Transient Outward K+ Current, IAf, in Mammalian Neurons
J. Neurosci., October 15, 2001; 21(20): 8004 - 8014.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. Bahring, L. M Boland, A. Varghese, M. Gebauer, and O. Pongs
Kinetic analysis of open- and closed-state inactivation transitions in human Kv4.2 A-type potassium channels
J. Physiol., August 15, 2001; 535(1): 65 - 81.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. A Greenwood, J. Ledoux, and N. Leblanc
Differential regulation of Ca2+-activated Cl- currents in rabbit arterial and portal vein smooth muscle cells by Ca2+-calmodulin-dependent kinase
J. Physiol., July 15, 2001; 534(2): 395 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. Rusnak and P. Mertz
Calcineurin: Form and Function
Physiol Rev, October 1, 2000; 80(4): 1483 - 1521.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. C. Sansom, R. Ma, P. K. Carmines, and D. A. Hall
Regulation of Ca2+-activated K+ channels by multifunctional Ca2+/calmodulin-dependent protein kinase
Am J Physiol Renal Physiol, August 1, 2000; 279(2): F283 - F288.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. L. McAnelly and H. H. Zakon
Coregulation of Voltage-Dependent Kinetics of Na+ and K+ Currents in Electric Organ
J. Neurosci., May 1, 2000; 20(9): 3408 - 3414.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. Herzig and J. Neumann
Effects of Serine/Threonine Protein Phosphatases on Ion Channels in Excitable Membranes
Physiol Rev, January 1, 2000; 80(1): 173 - 210.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Tessier, P. Karczewski, E.-G. Krause, Y. Pansard, C. Acar, M. Lang-Lazdunski, J.-J. Mercadier, and S. N. Hatem
Regulation of the Transient Outward K+ Current by Ca2+/Calmodulin-Dependent Protein Kinases II in Human Atrial Myocytes
Circ. Res., October 29, 1999; 85(9): 810 - 819.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Zhu, C. H. Gelband, P. Posner, and C. Sumners
Angiotensin II Decreases Neuronal Delayed Rectifier Potassium Current: Role of Calcium/Calmodulin-Dependent Protein Kinase II
J Neurophysiol, September 1, 1999; 82(3): 1560 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Peretz, A. Sobko, and B. Attali
Tyrosine kinases modulate K+ channel gating in mouse Schwann cells
J. Physiol., September 1, 1999; 519(2): 373 - 384.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. Qian and P. Saggau
Activity-dependent modulation of K+ currents at presynaptic terminals of mammalian central synapses
J. Physiol., September 1, 1999; 519(2): 427 - 437.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. D. Koh, B. A Perrino, W. J Hatton, J. L Kenyon, and K. M Sanders
Novel regulation of the A-type K+ current in murine proximal colon by calcium-calmodulin-dependent protein kinase II
J. Physiol., May 15, 1999; 517(1): 75 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. D. Wickenden, T. J. Jegla, R. Kaprielian, and P. H. Backx
Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle
Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1599 - H1607.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
M. V. Brahmajothi, D. L. Campbell, R. L. Rasmusson, M. J. Morales, J. S. Trimmer, J. M. Nerbonne, and H. C. Strauss
Distinct Transient Outward Potassium Current (Ito) Phenotypes and Distribution of Fast-inactivating Potassium Channel Alpha Subunits in Ferret Left Ventricular Myocytes
J. Gen. Physiol., April 1, 1999; 113(4): 581 - 600.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Leicher, R. Bahring, D. Isbrandt, and O. Pongs
Coexpression of the KCNA3B Gene Product with Kv1.5 Leads to a Novel A-type Potassium Channel
J. Biol. Chem., December 25, 1998; 273(52): 35095 - 35101.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Meiri, M.-K. Sun, Z. Segal, and D. L. Alkon
Memory and long-term potentiation (LTP) dissociated: Normal spatial memory despite CA1 LTP elimination with Kv1.4 antisense
PNAS, December 8, 1998; 95(25): 15037 - 15042.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. J. Berman and L. Maler
Interaction of GABAB-Mediated Inhibition With Voltage-Gated Currents of Pyramidal Cells: Computational Mechanism of a Sensory Searchlight
J Neurophysiol, December 1, 1998; 80(6): 3197 - 3213.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Peretz, I. Abitbol, A. Sobko, C.-F. Wu, and B. Attali
A Ca2+/Calmodulin-Dependent Protein Kinase Modulates Drosophila Photoreceptor K+ Currents: A Role in Shaping the Photoreceptor Potential
J. Neurosci., November 15, 1998; 18(22): 9153 - 9162.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. D. Whim and L. K. Kaczmarek
Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell Neurons
J. Neurosci., November 15, 1998; 18(22): 9171 - 9180.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. Barros, D. Gomez-Varela, C. G Viloria, T. Palomero, T. Giraldez, and P. de la Pena
Modulation of human erg K+ channel gating by activation of a G protein-coupled receptor and protein kinase C
J. Physiol., September 1, 1998; 511(2): 333 - 346.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
E. J. Beck, R. G. Sorensen, S. J. Slater, and M. Covarrubias
Interactions between Multiple Phosphorylation Sites in the Inactivation Particle of a K+ Channel: Insights into the Molecular Mechanism of Protein Kinase C Action
J. Gen. Physiol., July 1, 1998; 112(1): 71 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. L. Rasmusson, M. J. Morales, S. Wang, S. Liu, D. L. Campbell, M. V. Brahmajothi, and H. C. Strauss
Inactivation of Voltage-Gated Cardiac K+ Channels
Circ. Res., April 20, 1998; 82(7): 739 - 750.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. C. Cooper, A. Milroy, Y. N. Jan, L. Y. Jan, and D. H. Lowenstein
Presynaptic Localization of Kv1.4-Containing A-Type Potassium Channels Near Excitatory Synapses in the Hippocampus
J. Neurosci., February 1, 1998; 18(3): 965 - 974.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Bahring, J. Dannenberg, H. C. Peters, T. Leicher, O. Pongs, and D. Isbrandt
Conserved Kv4 N-terminal Domain Critical for Effects of Kv Channel-interacting Protein 2.2 on Channel Expression and Gating
J. Biol. Chem., June 22, 2001; 276(26): 23888 - 23894.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Wang, B. Yang, Y. Zhang, H. Han, J. Wang, H. Shi, and Z. Wang
Different Subtypes of alpha 1-Adrenoceptor Modulate Different K+ Currents via Different Signaling Pathways in Canine Ventricular Myocytes
J. Biol. Chem., October 26, 2001; 276(44): 40811 - 40816.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-