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Volume 17, Number 10,
Issue of May 15, 1997
pp. 3778-3795
Copyright ©1997 Society for Neuroscience
Short-Term Plasticity during Intrathalamic Augmenting Responses
in Decorticated Cats
Received Nov. 5, 1996; revised Jan. 28, 1997; accepted Feb. 21, 1997.
Mircea Steriade and
Igor Timofeev
Laboratoire de Neurophysiologie, Faculté de Médecine,
Université Laval, Quebec, Canada G1K 7P4
The intrathalamic mechanisms of frequency-dependent augmenting
responses were investigated in decorticated cats by means of intracellular recordings from thalamocortical (TC) neurons in ventrolateral (VL) nucleus, including simultaneous impalements from two TC neurons. Pulse trains (10 Hz) applied to VL nucleus elicited two types of augmenting responses: (1) in 68% of cells, the
incremental responses occurred on a progressive depolarization associated with the decrease in IPSPs produced by preceding stimuli in
the train; (2) in the remaining cells, progressively growing low-threshold (LT) responses resulted from the enhancement of Cl -dependent IPSPs, giving rise to postinhibitory rebound
bursts, followed by a self-sustained sequence of spindle waves.
Although in some TC cells the augmenting responses developed from LT
responses once the latter reached a given level of depolarization,
other neurons displayed augmenting responses immediately after the
early antidromic spike that depolarized the neuron to the required
level, without an intermediate step of LT rebound. Repeated pulse
trains led to a progressive and persistent increase in slow
depolarizing responses of TC cells, as well as to a persistent and
prolonged decrease in the amplitudes of the IPSPs. On the basis of
parallel experiments, we propose that the two types of augmentation in TC cells are a result of contrasting responses of thalamic reticular neurons evoked by repetitive thalamic stimuli: decremental responses, which may account for disinhibition leading to depolarizing responses in TC cells, and incremental responses, explaining the progressive hyperpolarization of TC cells. These data demonstrate that
frequency-dependent changes in neuronal excitability are present in the
thalamus of a decorticated hemisphere and suggest that short-term
plasticity processes in the gateway to the cerebral cortex may
decisively influence cortical excitability during repetitive
responses.
Key words:
augmenting;
plasticity;
thalamus;
intracellular;
high-threshold;
low-threshold
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