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Volume 17, Number 11, Issue of June 1, 1997 pp. 4282-4292
Copyright ©1997 Society for Neuroscience

Selective Expression of Dopamine D₃ Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain

Received Oct. 28, 1996; revised March 14, 1997; accepted March 21, 1997.

Jorge Diaz¹, Sophie Ridray¹, Virginie Mignon², Nathalie Griffon², Jean-Charles Schwartz², and Pierre Sokoloff²

¹ Laboratoire de Physiologie, Université René Descartes, 75006 Paris, France, and ² Unité de Neurobiologie et Pharmacologie de l'Institut National de la Santé et de la Recherche Médicale, Centre Paul Broca, 75014 Paris, France

We studied by in situ hybridization histochemistry the expression of D₃ receptor (D₃R) mRNA at various stages of rat brain development. The first expression of D₃R mRNA was detected at embryonic day 14 (E14) in the striatal and rhinencephalic neuroepithelia and throughout the tectal neuroepithelium. From E16 to E19 D₃R mRNA expression extended along a rostrocaudal axis to additional proliferative ventricular zones of the basal forebrain, including the neuroepithelia of the olfactory bulb, nucleus accumbens, septum, and amygdala, whereas D₁ and D₂ receptor (D₁R and D₂R) mRNAs were expressed predominantly by migrating neuroblasts and/or differentiating striatal neurons. Only a few neuroblasts, migrating in the lateral cortical stream or developing as cerebellar Purkinje cells, expressed D₃R mRNA from E18. At birth D₃R expression mRNA appeared in differentiating neuronal fields of the nucleus accumbens and medial mamillary body primordia and on P5 reached a distribution similar to that found in adult. In addition, a transient upregulation was detected on P5 in the medial mamillary bodies, parietofrontal cortex, and olfactory tubercle. In the adult brain D₃R gene expression continued in the striatal proliferative subventricular zone. The late expression D₃R mRNA in neurons, after achievement of dopamine innervation, supports the existence of a regulating factor released from dopamine neurons, as suggested by denervation studies in the adult. The sustained and abundant D₃R gene expression, predominantly in germinative neuroepithelial zones actively involved in neurogenesis of most basal forebrain structures, supports the hypothesis of a neurogenetic but minor morphogenetic modulatory role for the D₃R during CNS development.

Key words: in situ hybridization; neuroepithelium; neurogenesis; forebrain development; dopamines; D₃R mRNA

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