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Volume 17, Number 11, Issue of June 1, 1997 pp. 4367-4381
Copyright ©1997 Society for Neuroscience

Transient Changes in Flocculonodular Lobe Protein Kinase C Expression during Vestibular Compensation

Received Jan. 16, 1997; revised March 4, 1997; accepted March 7, 1997.

Mark M. Goto¹, Guillermo G. Romero², and Carey D. Balaban^{1, 3}

Departments of ¹ Otolaryngology, ² Pharmacology, and ³ Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

Protein kinase C (PKC) is a family of intracellular signal transduction enzymes, comprising isoforms that vary in sensitivity to calcium, arachidonic acid, and diacylglycerol. PKC isoforms , , and  are expressed by cerebellar Purkinje cells and neurons in the cerebellar nuclei and vestibular nuclei of the Long-Evans rat. In control rats, these PKCs are distributed symmetrically in the flocculonodular-lobe Purkinje cells. Behavioral recovery from vestibular dysfunction produced by unilateral labyrinthectomy (UL) is accompanied by asymmetric expression of PKC isoforms in these regions within 6 hr after UL. These expression changes were localized within parasagittal regions of the flocculus and nodulus. The distribution of PKC, -, and - were identical, suggesting that they are coregulated in cerebellar Purkinje cells during this early compensatory period. The pattern of Purkinje cell PKC expression returned to the control, symmetric distribution within 24 hr after UL. It is hypothesized that these regional changes in Purkinje cell PKC expression are an early intracellular signal contributing to vestibular compensation. In particular, regulation of PKC expression may contribute to changes in the efficacy of cerebellar synaptic plasticity during the acute post-UL period.

Key words: vestibular compensation; protein kinase C; cerebellum; labyrinthectomy; Purkinje cells; signal transduction proteins

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