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Volume 17, Number 11,
Issue of June 1, 1997
pp. 4398-4405
Copyright ©1997 Society for Neuroscience
The Low-Affinity Neurotrophin Receptor p75 Regulates the Function
But Not the Selective Survival of Specific Subpopulations of Sensory
Neurons
Received Nov. 27, 1996; revised Feb. 21, 1997; accepted March 14, 1997.
Cheryl L. Stucky and
Martin Koltzenburg
Department of Neurology, University of Würzburg, D-97080
Würzburg, Germany
Mice with a targeted deletion of the low-affinity neurotrophin
receptor p75 (p75 /) exhibit a 50% loss of large- and
small-diameter sensory neurons in the dorsal root ganglion. Using
neurophysiological recording techniques, we now show that p75 is not
required for the survival of specific, functionally defined
subpopulations of sensory neurons. Rather, p75/ mice exhibit losses
of neurons that subserve nociceptive as well as non-nociceptive
functions. The receptive properties of large myelinated afferent fibers
were normal in p75/ mice. However, the receptive properties of
subpopulations of afferent fibers with thin myelinated or unmyelinated
axons were strikingly impaired in mice lacking p75. Furthermore, the presence of p75 is required for normal mechanotransduction in C fibers
and D-hair receptors and normal heat sensitivity in A-fiber nociceptors.
Key words:
NGF;
BDNF;
NT-3;
NT-4;
nociceptor;
dorsal root ganglion;
apoptosis;
mechanosensation;
electrophysiology
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