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Volume 17, Number 12, Issue of June 15, 1997 pp. 4652-4661
Copyright ©1997 Society for Neuroscience

Identification and Functional Characterization of a K+ Channel alpha -Subunit with Regulatory Properties Specific to Brain

Received Oct. 22, 1996; revised March 27, 1997; accepted April 8, 1997.

Antonio Castellano1, Maria D. Chiara1, Britt Mellström2, Antonio Molina1, Francisco Monje1, José R. Naranjo2, and José López-Barneo1

1 Facultad de Medicina, Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, E-41009, Sevilla, Spain, and 2 Instituto Cajal, Consejo Superior de Investigaciones Científicas, E-28006, Madrid, Spain

The physiological diversity of K+ channels mainly depends on the expression of several genes encoding different alpha -subunits. We have cloned a new K+ channel alpha -subunit (Kv2.3r) that is unable to form functional channels on its own but that has a major regulatory function. Kv2.3r can coassemble selectively with other alpha -subunits to form functional heteromultimeric K+ channels with kinetic properties that differ from those of the parent channels. Kv2.3r is expressed exclusively in the brain, being concentrated particularly in neocortical neurons. The functional expression of this regulatory alpha -subunit represents a novel mechanism without precedents in voltage-gated channels, which might contribute to further increase the functional diversity of K+ channels necessary to specify the intrinsic electrical properties of individual neurons.

Key words: K+ channels; alpha -subunit; cloning; regulatory mechanism; channel diversity; neurons




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