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Volume 17, Number 12, Issue of June 15, 1997 pp. 4734-4743
Copyright ©1997 Society for Neuroscience

Neurexin Is Expressed on Nerves, But Not at Nerve Terminals, in the Electric Organ

Received March 3, 1997; revised April 1, 1997; accepted April 9, 1997.

Anthony B. Russell and Steven S. Carlson

Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195

Neurexins are highly variable transmembrane proteins hypothesized to be nerve terminal-specific cell adhesion molecules. As a test of the hypothesis that neurexin is restricted to the nerve terminal, we examined neurexins in the electric organ of the elasmobranch electric fish. Specific antibodies generated against the intracellular domain of electric fish neurexin were used in immunocytochemical and Western blot analyses of the electromotor neurons that innervate the electric organ. Our results indicate that neurexin is not expressed at electric organ nerve terminals, as expected by the neurexin hypothesis. Instead, neurexin is expressed by electromotor neurons and on myelinated axons. This neurexin has a molecular weight of 140 kDa, consistent with an -neurexin. In addition, we find that perineurial cells of the electromotor nerve also express a neurexin. These cells surround bundles of axons to form a diffusion barrier and are thought to be a special form of fibroblast. The results of the study argue against a universal role for neurexins as nerve terminal-specific proteins but suggest that neurexins are involved in axon-Schwann cell and perineurial cell interactions.

Key words: neurexin; electric organ; Torpedo; Narcine; electromotor nucleus; glutathione S-transferase; perineurium, Schwann cell

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