WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (281)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lu, Y.-M.
Right arrow Articles by Roder, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, Y.-M.
Right arrow Articles by Roder, J. C.

 Previous Article  |  Next Article 

Volume 17, Number 13, Issue of July 1, 1997 pp. 5196-5205
Copyright ©1997 Society for Neuroscience

Mice Lacking Metabotropic Glutamate Receptor 5 Show Impaired Learning and Reduced CA1 Long-Term Potentiation (LTP) But Normal CA3 LTP

Received Nov. 11, 1996; revised April 8, 1997; accepted April 11, 1997.

You-Ming Lu1, Zhengping Jia1, Christopher Janus1, Jeffrey T. Henderson1, Robert Gerlai1, J. Martin Wojtowicz2, and John C. Roder1

1 Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada, and 2 Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other glutamate receptors. The CNS revealed normal development of gross anatomical features. To examine synaptic functions we measured evoked field EPSPs in the hippocampal slice. Measures of presynaptic function, such as paired pulse facilitation in mutant CA1 neurons, were normal. The response of mutant CA1 neurons to low concentrations of (1S,3R)-1-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) was missing, which suggests that mGluR5 may be the primary high affinity ACPD receptor in these neurons. Long-term potentiation (LTP) in mGluR5 mutants was significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remained intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway. Some of the difference in CA1 LTP could lie at the level of expression, because the reduction of LTP in the mutants was no longer observed 20 min after tetanus in the presence of 2-amino-5-phosphonopentanoate. We propose that mGluR5 plays a key regulatory role in NMDAR-dependent LTP. These mutant mice were also impaired in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test. This is consistent with the hypothesis that LTP in the CA1 region may underlie spatial learning and memory.

Key words: hippocampus; gene targeting; long-term potentiation; metabotropic glutamate receptor 5; spatial learning; snyaptic function




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
M. C. Montana, L. F. Cavallone, K. K. Stubbert, A. D. Stefanescu, E. D. Kharasch, and R. W. Gereau IV
The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine
J. Pharmacol. Exp. Ther., September 1, 2009; 330(3): 834 - 843.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. Rylander, A. Recchia, F. Mela, A. Dekundy, W. Danysz, and M. A. Cenci
Pharmacological Modulation of Glutamate Transmission in a Rat Model of L-DOPA-Induced Dyskinesia: Effects on Motor Behavior and Striatal Nuclear Signaling
J. Pharmacol. Exp. Ther., July 1, 2009; 330(1): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
J. W. Rudy and P. Matus-Amat
DHPG activation of group 1 mGluRs in BLA enhances fear conditioning
Learn. Mem., June 24, 2009; 16(7): 421 - 425.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Xu, Y. Zhu, A. Contractor, and S. F. Heinemann
mGluR5 Has a Critical Role in Inhibitory Learning
J. Neurosci., March 25, 2009; 29(12): 3676 - 3684.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. Zhong, W. Liu, Z. Gu, and Z. Yan
Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization
J. Physiol., September 15, 2008; 586(18): 4465 - 4479.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Jeon, I. Song, W. Guido, K. Kim, E. Kim, U. Oh, and H.-S. Shin
Ablation of Ca2+ Channel {beta}3 Subunit Leads to Enhanced N-Methyl-D-aspartate Receptor-dependent Long Term Potentiation and Improved Long Term Memory
J. Biol. Chem., May 2, 2008; 283(18): 12093 - 12101.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. Dolen and M. F. Bear
Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome
J. Physiol., March 15, 2008; 586(6): 1503 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. L. Clem, T. Celikel, and A. L. Barth
Ongoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex
Science, January 4, 2008; 319(5859): 101 - 104.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. I. Boulware, H. Kordasiewicz, and P. G. Mermelstein
Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons
J. Neurosci., September 12, 2007; 27(37): 9941 - 9950.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Kirschstein, M. Bauer, L. Muller, C. Ruschenschmidt, M. Reitze, A. J. Becker, S. Schoch, and H. Beck
Loss of Metabotropic Glutamate Receptor-Dependent Long-Term Depression via Downregulation of mGluR5 after Status Epilepticus
J. Neurosci., July 18, 2007; 27(29): 7696 - 7704.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
B. H. Gabra, F. K. Kessler, J. K. Ritter, W. L. Dewey, and F. L. Smith
Decrease in N-Methyl-D-aspartic Acid Receptor-NR2B Subunit Levels by Intrathecal Short-Hairpin RNA Blocks Group I Metabotropic Glutamate Receptor-Mediated Hyperalgesia
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 186 - 194.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. J. Zhu and D. M. Lovinger
Persistent Synaptic Activity Produces Long-Lasting Enhancement of Endocannabinoid Modulation and Alters Long-Term Synaptic Plasticity
J Neurophysiol, June 1, 2007; 97(6): 4386 - 4389.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Wettschureck, M. van der Stelt, H. Tsubokawa, H. Krestel, A. Moers, S. Petrosino, G. Schutz, V. Di Marzo, and S. Offermanns
Forebrain-Specific Inactivation of Gq/G11 Family G Proteins Results in Age-Dependent Epilepsy and Impaired Endocannabinoid Formation
Mol. Cell. Biol., August 1, 2006; 26(15): 5888 - 5894.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Kuriu, A. Inoue, H. Bito, K. Sobue, and S. Okabe
Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms.
J. Neurosci., July 19, 2006; 26(29): 7693 - 7706.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. J. Volk, C. A. Daly, and K. M. Huber
Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression
J Neurophysiol, April 1, 2006; 95(4): 2427 - 2438.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. Homayoun and B. Moghaddam
Bursting of Prefrontal Cortex Neurons in Awake Rats is Regulated by Metabotropic Glutamate 5 (mGlu5) Receptors: Rate-dependent Influence and Interaction with NMDA Receptors
Cereb Cortex, January 1, 2006; 16(1): 93 - 105.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. S. Cowen, E. Djouma, and A. J. Lawrence
The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems
J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 590 - 600.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. Manahan-Vaughan and K.-H. Braunewell
The Metabotropic Glutamate Receptor, mGluR5, is a Key Determinant of Good and Bad Spatial Learning Performance and Hippocampal Synaptic Plasticity
Cereb Cortex, November 1, 2005; 15(11): 1703 - 1713.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
B. Poschel, B. Wroblewska, U. Heinemann, and D. Manahan-Vaughan
The Metabotropic Glutamate Receptor mGluR3 is Critically Required for Hippocampal Long-term Depression and Modulates Long-term Potentiation in the Dentate Gyrus of Freely Moving Rats
Cereb Cortex, September 1, 2005; 15(9): 1414 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. P. Tyszkiewicz and Z. Yan
{beta}-Amyloid Peptides Impair PKC-Dependent Functions of Metabotropic Glutamate Receptors in Prefrontal Cortical Neurons
J Neurophysiol, June 1, 2005; 93(6): 3102 - 3111.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. J. Bradbury, U. Campbell, D. Giracello, D. Chapman, C. King, L. Tehrani, N. D. P. Cosford, J. Anderson, M. A. Varney, and A. M. Strack
Metabotropic Glutamate Receptor mGlu5 Is a Mediator of Appetite and Energy Balance in Rats and Mice
J. Pharmacol. Exp. Ther., April 1, 2005; 313(1): 395 - 402.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. J. Maher, R. L. MacKinnon II, J. Bai, E. R. Chapman, and P. T. Kelly
Activation of Postsynaptic Ca2+ Stores Modulates Glutamate Receptor Cycling in Hippocampal Neurons
J Neurophysiol, January 1, 2005; 93(1): 178 - 188.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Moriyoshi, K. Iijima, H. Fujii, H. Ito, Y. Cho, and S. Nakanishi
Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors
PNAS, June 8, 2004; 101(23): 8614 - 8619.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S.-J. Wang and T. S. Sihra
Noncompetitive Metabotropic Glutamate5 Receptor Antagonist (E)-2-Methyl-6-styryl-pyridine (SIB1893) Depresses Glutamate Release through Inhibition of Voltage-Dependent Ca2+ Entry in Rat Cerebrocortical Nerve Terminals (Synaptosomes)
J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 951 - 958.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. Naie and D. Manahan-Vaughan
Regulation by Metabotropic Glutamate Receptor 5 of LTP in the Dentate Gyrus of Freely Moving Rats: Relevance for Learning and Memory Formation
Cereb Cortex, February 1, 2004; 14(2): 189 - 198.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Battaglia, C. L. Busceti, G. Molinaro, F. Biagioni, M. Storto, F. Fornai, F. Nicoletti, and V. Bruno
Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Contributes to the Development of Nigro-Striatal Damage Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
J. Neurosci., January 28, 2004; 24(4): 828 - 835.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K. Ye and S. H. Snyder
PIKE GTPase: a novel mediator of phosphoinositide signaling
J. Cell Sci., January 15, 2004; 117(2): 155 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. A. LYNCH
Long-Term Potentiation and Memory
Physiol Rev, January 1, 2004; 84(1): 87 - 136.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Kotecha, M. F. Jackson, A. Al-Mahrouki, J. C. Roder, B. A. Orser, and J. F. MacDonald
Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons
J. Biol. Chem., July 18, 2003; 278(30): 27742 - 27749.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Stoop, F. Conquet, B. Zuber, L. L. Voronin, and E. Pralong
Activation of Metabotropic Glutamate 5 and NMDA Receptors Underlies the Induction of Persistent Bursting and Associated Long-Lasting Changes in CA3 Recurrent Connections
J. Neurosci., July 2, 2003; 23(13): 5634 - 5644.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
G. G. Kinney, M. Burno, U. C. Campbell, L. M. Hernandez, D. Rodriguez, L. J. Bristow, and P. J. Conn
Metabotropic Glutamate Subtype 5 Receptors Modulate Locomotor Activity and Sensorimotor Gating in Rodents
J. Pharmacol. Exp. Ther., July 1, 2003; 306(1): 116 - 123.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
V. Coutinho and T. Knopfel
Book Review: Metabotropic Glutamate Receptors: Electrical and Chemical Signaling Properties
Neuroscientist, December 1, 2002; 8(6): 551 - 561.
[Abstract] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. J. Anderson, S. P. Rao, B. Rowe, D. R. Giracello, G. Holtz, D. F. Chapman, L. Tehrani, M. J. Bradbury, N. D. P. Cosford, and M. A. Varney
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization
J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1044 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Miura, M. Watanabe, S. Offermanns, M. I. Simon, and M. Kano
Group I Metabotropic Glutamate Receptor Signaling via Galpha q/Galpha 11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1
J. Neurosci., October 1, 2002; 22(19): 8379 - 8390.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. C. Faas, H. Adwanikar, R. W. Gereau IV, and P. Saggau
Modulation of Presynaptic Calcium Transients by Metabotropic Glutamate Receptor Activation: A Differential Role in Acute Depression of Synaptic Transmission and Long-Term Depression
J. Neurosci., August 15, 2002; 22(16): 6885 - 6890.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Heidinger, P. Manzerra, X. Q. Wang, U. Strasser, S.-P. Yu, D. W. Choi, and M. M. Behrens
Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons
J. Neurosci., July 1, 2002; 22(13): 5452 - 5461.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. M. Rodrigues, E. P. Bauer, C. R. Farb, G. E. Schafe, and J. E. LeDoux
The Group I Metabotropic Glutamate Receptor mGluR5 Is Required for Fear Memory Formation and Long-Term Potentiation in the Lateral Amygdala
J. Neurosci., June 15, 2002; 22(12): 5219 - 5229.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
G. Lopez-Bendito, R. Shigemoto, A. Fairen, and R. Lujan
Differential Distribution of Group I Metabotropic Glutamate Receptors during Rat Cortical Development
Cereb Cortex, June 1, 2002; 12(6): 625 - 638.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S.-C. Chuang, W. Zhao, S. R Young, F. Conquet, R. Bianchi, and R. K S Wong
Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells
J. Physiol., May 15, 2002; 541(1): 113 - 121.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. E. Zink, E. Anderson, J. Boyle, L. Hock, J. Rodriguez-Sierra, H. Xiong, H. E. Gendelman, and Y. Persidsky
Impaired Spatial Cognition and Synaptic Potentiation in a Murine Model of Human Immunodeficiency Virus Type 1 Encephalitis
J. Neurosci., March 15, 2002; 22(6): 2096 - 2105.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. T. Diagana, U. Thomas, S. N. Prokopenko, B. Xiao, P. F. Worley, and J. B. Thomas
Mutation of Drosophila homer Disrupts Control of Locomotor Activity and Behavioral Plasticity
J. Neurosci., January 15, 2002; 22(2): 428 - 436.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Sansig, T. J. Bushell, V. R. J. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, et al.
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7
J. Neurosci., November 15, 2001; 21(22): 8734 - 8745.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X.-T. Jin, C. J. Beaver, Q. Ji, and N. W. Daw
Effect of the Group I Metabotropic Glutamate Agonist DHPG on the Visual Cortex
J Neurophysiol, October 1, 2001; 86(4): 1622 - 1631.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. V. Catania, M. Bellomo, V. Di Giorgi-Gerevini, G. Seminara, R. Giuffrida, R. Romeo, A. De Blasi, and F. Nicoletti
Endogenous Activation of Group-I Metabotropic Glutamate Receptors Is Required for Differentiation and Survival of Cerebellar Purkinje Cells
J. Neurosci., October 1, 2001; 21(19): 7664 - 7673.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Mannaioni, M. J. Marino, O. Valenti, S. F. Traynelis, and P. J. Conn
Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function
J. Neurosci., August 15, 2001; 21(16): 5925 - 5934.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-y. Lan, V. A. Skeberdis, T. Jover, X. Zheng, M. V. L. Bennett, and R. S. Zukin
Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking
J. Neurosci., August 15, 2001; 21(16): 6058 - 6068.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Kleppisch, V. Voigt, R. Allmann, and S. Offermanns
G{alpha}q-Deficient Mice Lack Metabotropic Glutamate Receptor-Dependent Long-Term Depression But Show Normal Long-Term Potentiation in the Hippocampal CA1 Region
J. Neurosci., July 15, 2001; 21(14): 4943 - 4948.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
K. M. Huber, J. C. Roder, and M. F. Bear
Chemical Induction of mGluR5- and Protein Synthesis-Dependent Long-Term Depression in Hippocampal Area CA1
J Neurophysiol, July 1, 2001; 86(1): 321 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
F. Ango, J.-P. Pin, J. C. Tu, B. Xiao, P. F. Worley, J. Bockaert, and L. Fagni
Dendritic and Axonal Targeting of Type 5 Metabotropic Glutamate Receptor Is Regulated by Homer1 Proteins and Neuronal Excitation
J. Neurosci., December 1, 2000; 20(23): 8710 - 8716.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. G. Chapman
Glutamate and Epilepsy
J. Nutr., April 1, 2000; 130(4): 1043 - 1043.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
S. N. Gomperts, R. Carroll, R. C. Malenka, and R. A. Nicoll
Distinct Roles for Ionotropic and Metabotropic Glutamate Receptors in the Maturation of Excitatory Synapses
J. Neurosci., March 15, 2000; 20(6): 2229 - 2237.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. M. Grover and C. Yan
Evidence for Involvement of Group II/III Metabotropic Glutamate Receptors in NMDA Receptor-Independent Long-Term Potentiation in Area CA1 of Rat Hippocampus
J Neurophysiol, December 1, 1999; 82(6): 2956 - 2969.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. B. Sawtell, K. M. Huber, J. C. Roder, and M. F. Bear
Induction of NMDA Receptor-Dependent Long-Term Depression in Visual Cortex Does Not Require Metabotropic Glutamate Receptors
J Neurophysiol, December 1, 1999; 82(6): 3594 - 3597.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. M. Nicolle, P. J. Colombo, M. Gallagher, and M. McKinney
Metabotropic Glutamate Receptor-Mediated Hippocampal Phosphoinositide Turnover Is Blunted in Spatial Learning-Impaired Aged Rats
J. Neurosci., November 1, 1999; 19(21): 9604 - 9610.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N Kato, T Tanaka, K Yamamoto, and Y Isomura
Distinct temporal profiles of activity-dependent calcium increase in pyramidal neurons of the rat visual cortex
J. Physiol., September 1, 1999; 519(2): 467 - 479.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. A. Varney, N. D. P. Cosford, C. Jachec, S. P. Rao, A. Sacaan, F.-F. Lin, L. Bleicher, E. M. Santori, P. J. Flor, H. Allgeier, et al.
SIB-1757 and SIB-1893: Selective, Noncompetitive Antagonists of Metabotropic Glutamate Receptor Type 5
J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 170 - 181.
[Abstract] [Full Text]

Home page
 Learn. Mem.Home page
D. Balschun, D. Manahan-Vaughan, T. Wagner, T. Behnisch, K. G. Reymann, and W. Wetzel
A Specific Role for Group I mGluRs in Hippocampal LTP and Hippocampus-Dependent Spatial Learning
Learn. Mem., March 1, 1999; 6(2): 138 - 152.
[Abstract] [Full Text]

Home page
 Learn. Mem.Home page
Z. Jia, Y. Lu, J. Henderson, F. Taverna, C. Romano, W. Abramow-Newerly, J. M. Wojtowicz, and J. Roder
Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5
Learn. Mem., September 1, 1998; 5(4): 331 - 343.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
V. W. Wilsch, T. Behnisch, T. Jager, K. G. Reymann, and D. Balschun
When Are Class I Metabotropic Glutamate Receptors Necessary for Long-Term Potentiation?
J. Neurosci., August 15, 1998; 18(16): 6071 - 6080.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. Minami, R. W. Gereau IV, M. Minami, S. F. Heinemann, and R. A. Harris
Effects of Ethanol and Anesthetics on Type 1 and 5 Metabotropic Glutamate Receptors Expressed in Xenopus laevis Oocytes
Mol. Pharmacol., January 1, 1998; 53(1): 148 - 156.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P. J. Flor, A. Neki, T. Abe, S. Nakanishi, et al.
Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus
J. Neurosci., October 1, 1997; 17(19): 7503 - 7522.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-