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Volume 17, Number 14, Issue of July 15, 1997 pp. 5493-5502
Copyright ©1997 Society for Neuroscience

HNMP-1: A Novel Hematopoietic and Neural Membrane Protein Differentially Regulated in Neural Development and Injury

Received Sept. 6, 1996; revised April 24, 1997; accepted May 7, 1997.

Laurel M. Bolin, Tom McNeil, Linda A. Lucian, Brigitte DeVaux, Karin Franz-Bacon, Daniel M. Gorman, Sandra Zurawski, Richard Murray, and Terrill K. McClanahan

DNAX Research Institute, Palo Alto, California 94304-1104

The hnmp-1 (hematopoietic neural membrane protein) gene encodes a protein with striking similarity to the tetra-transmembrane-spanning protein encoded by pmp22. hnmp-1 was cloned from an elutriated human monocyte library and is expressed in various human hematopoietic and lymphoid lineages as well as adult mouse spleen and thymus. In the mouse nervous system, HNMP-1 mRNA is temporally expressed by Schwann cells during sciatic nerve myelination. Dorsal root ganglia sensory and spinal cord alpha -motoneurons acquire HNMP-1 protein selectively throughout development. In the fiber tracts of the spinal cord and in sciatic nerve, HNMP-1 protein is axon-associated. Additionally a rapid and sustained level of HNMP-1 expression is observed in response to acute PNS injury. HNMP-1 is constituitively induced in sciatic nerve of Trembler J mice, which are mutant for pmp22 and have a demyelinating/hypomyelinating phenotype. The expression pattern of HNMP-1 suggests a possible role for this molecule during active myelination.

Key words: Schwann cell; DRG; sensory neuron; motoneuron; regeneration; PMP22; hematopoiesis; development




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