QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (21) Citing Articles via Google Scholar Google Scholar Articles by Samoriski, G. M. Articles by Applegate, C. D. Search for Related Content PubMed PubMed Citation Articles by Samoriski, G. M. Articles by Applegate, C. D.

 Previous Article  |  Next Article 

Volume 17, Number 14, Issue of July 15, 1997 pp. 5581-5590
Copyright ©1997 Society for Neuroscience

Repeated Generalized Seizures Induce Time-Dependent Changes in the Behavioral Seizure Response Independent of Continued Seizure Induction

Received Aug. 23, 1996; revised April 21, 1997; accepted April 24, 1997.

Gary M. Samoriski and Craig D. Applegate

Program in Neuroscience and The Comprehensive Epilepsy Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642

This study examined both the acute and long-lasting changes in seizure susceptibility that occur in response to the repeated induction of generalized seizure activity. Daily flurothyl-induced generalized clonic seizures resulted in a progressive decrease in both the generalized seizure threshold and the latency to the first myoclonic jerk. The threshold reduction was significant as early as the second trial and was maximal by trial 5. However, a minimum of eight seizures was necessary for the maximal reduction to be long-lasting. The present study also examined the effects of the number of seizures and the duration of the stimulation-free interval on the type of generalized seizure expressed. During the induction phase of the experiment, only generalized clonic seizures ("forebrain seizures") were expressed. If, however, the animal was retested after a 1, 2, 3, or 4 week stimulation-free interval, a progressive increase in both the proportion of animals expressing "brainstem seizure" behaviors and the median seizure score was observed. The progression of flurothyl-induced generalized seizure behaviors was significantly altered if (1) a minimum of eight generalized clonic seizures had been expressed, and (2) a minimum of a 2 week stimulation-free interval followed. Fewer generalized clonic seizures failed to reliably produce changes in seizure phenotype, even after extended stimulus-free intervals. These data indicate that specific kindling processes are initiated during the interval of repeated seizure induction and evolve in the absence of continued seizure induction. Furthermore, these mechanisms of epileptogenesis were found to be manifest predominantly as a change in the seizure phenotype expressed and to proceed independent of changes in the generalized seizure threshold.

Key words: epileptogenesis; generalized clonic seizure; generalized tonic seizure; kindling; flurothyl; mouse

This article has been cited by other articles:

				H. J. Wenzel, C. A. Robbins, L.-H. Tsai, and P. A. Schwartzkroin Abnormal Morphological and Functional Organization of the Hippocampus in a p35 Mutant Model of Cortical Dysplasia Associated with Spontaneous Seizures J. Neurosci., February 1, 2001; 21(3): 983 - 998. [Abstract] [Full Text] [PDF]

				M. H. M. Bibb, R. R. Diehl, and D. Linden Neurocardiogenic Syncope N. Engl. J. Med., December 17, 1998; 339(25): 1857 - 1857. [Full Text]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help