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Volume 17, Number 14, Issue of July 15, 1997 pp. 5610-5621
Copyright ©1997 Society for Neuroscience

Temporal Dynamics of Graded Synaptic Transmission in the Lobster Stomatogastric Ganglion

Received March 5, 1997; revised April 29, 1997; accepted April 30, 1997.

Yair Manor, Farzan Nadim, L. F. Abbott, and Eve Marder

Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02254

Synaptic transmission between neurons in the stomatogastric ganglion of the lobster Panulirus interruptus is a graded function of membrane potential, with a threshold for transmitter release in the range of 50 to 60 mV. We studied the dynamics of graded transmission between the lateral pyloric (LP) neuron and the pyloric dilator (PD) neurons after blocking action potential-mediated transmission with 0.1 µM tetrodotoxin. We compared the graded IPSPs (gIPSPs) from LP to PD neurons evoked by square pulse presynaptic depolarizations with those potentials evoked by realistic presynaptic waveforms of variable frequency, amplitude, and duty cycle. The gIPSP shows frequency-dependent synaptic depression. The recovery from depression is slow, and as a result, the gIPSP is depressed at normal pyloric network frequencies. Changes in the duration of the presynaptic depolarization produce nonintuitive changes in the amplitude and time course of the postsynaptic responses, which are again frequency-dependent. Taken together, these data demonstrate that the measurements of synaptic efficacy that are used to understand neural network function are best made using presynaptic waveforms and patterns of activity that mimic those in the functional network.

Key words: graded synaptic transmission; pyloric network; central pattern generation; oscillations; synaptic depression; inhibition

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