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Previous Article | Next Article
Volume 17, Number 15, Issue of August 1, 1997 pp. 5830-5842
Copyright ©1997 Society for NeuroscienceOCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons
Received March 10, 1997; revised May 5, 1997; accepted May 12, 1997.
Yoshihiro Yoshihara1, 2, 3, Miwa Kawasaki1, Atsushi Tamada1, 3, Hiroko Fujita3, Hideyuki Hayashi2, Hiroyuki Kagamiyama2, and Kensaku Mori1, 3 1 Department of Neuroscience, Osaka Bioscience Institute, Suita, Osaka 565, Japan, 2 Department of Biochemistry, Osaka Medical College, Takatsuki, Osaka 569, Japan, and 3 Laboratory for Neuronal Recognition Molecules, Frontier Research Program, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-01, Japan
Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal surface glycoprotein expressed by subsets of both olfactory and vomeronasal axons in a zone-specific manner. OCAM is a novel homophilic adhesion molecule belonging to the immunoglobulin superfamily with striking structural homology to neural cell adhesion molecule. In both the main and accessory olfactory systems, OCAM mRNA is expressed by sensory neurons in restricted chemoreceptor expression zones, and OCAM protein-expressing axons project to the glomeruli in the corresponding zones of the main and accessory bulbs. OCAM protein is expressed on subsets of growing sensory axons in explant cultures even in the absence of the target bulb. These results demonstrate a precisely coordinated zonal expression of chemoreceptors and OCAM and suggest that OCAM may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
Key words: OCAM; cell adhesion molecule; immunoglobulin superfamily; NCAM; olfactory system; odorant receptors; primary olfactory axons; zone-to-zone projection
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