 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 17, Number 15, Issue of August 1, 1997 pp. 5830-5842
Copyright ©1997 Society for NeuroscienceOCAM: A New Member of the Neural Cell Adhesion Molecule Family Related to Zone-to-Zone Projection of Olfactory and Vomeronasal Axons
Received March 10, 1997; revised May 5, 1997; accepted May 12, 1997.
Yoshihiro Yoshihara1, 2, 3, Miwa Kawasaki1, Atsushi Tamada1, 3, Hiroko Fujita3, Hideyuki Hayashi2, Hiroyuki Kagamiyama2, and Kensaku Mori1, 3 1 Department of Neuroscience, Osaka Bioscience Institute, Suita, Osaka 565, Japan, 2 Department of Biochemistry, Osaka Medical College, Takatsuki, Osaka 569, Japan, and 3 Laboratory for Neuronal Recognition Molecules, Frontier Research Program, The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-01, Japan
Zone-to-zone projection of olfactory and vomeronasal sensory axons underlies the topographic and functional mapping of chemoreceptor expression zones of the sensory epithelia onto zonally arranged glomeruli in the main and accessory olfactory bulbs. Here we identified OCAM (R4B12 antigen), an axonal surface glycoprotein expressed by subsets of both olfactory and vomeronasal axons in a zone-specific manner. OCAM is a novel homophilic adhesion molecule belonging to the immunoglobulin superfamily with striking structural homology to neural cell adhesion molecule. In both the main and accessory olfactory systems, OCAM mRNA is expressed by sensory neurons in restricted chemoreceptor expression zones, and OCAM protein-expressing axons project to the glomeruli in the corresponding zones of the main and accessory bulbs. OCAM protein is expressed on subsets of growing sensory axons in explant cultures even in the absence of the target bulb. These results demonstrate a precisely coordinated zonal expression of chemoreceptors and OCAM and suggest that OCAM may play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
Key words: OCAM; cell adhesion molecule; immunoglobulin superfamily; NCAM; olfactory system; odorant receptors; primary olfactory axons; zone-to-zone projection
This article has been cited by other articles:
R. Tirindelli, M. Dibattista, S. Pifferi, and A. Menini
From Pheromones to Behavior
Physiol Rev, July 1, 2009; 89(3): 921 - 956.
[Abstract] [Full Text] [PDF]
N. Miyasaka, K. Morimoto, T. Tsubokawa, S.-i. Higashijima, H. Okamoto, and Y. Yoshihara
From the Olfactory Bulb to Higher Brain Centers: Genetic Visualization of Secondary Olfactory Pathways in Zebrafish
J. Neurosci., April 15, 2009; 29(15): 4756 - 4767.
[Abstract] [Full Text] [PDF]
L. Belluscio and D. M. Cummings
Charting Plasticity in the Regenerating Maps of the Mammalian Olfactory Bulb
Neuroscientist, June 1, 2008; 14(3): 251 - 263.
[Abstract] [PDF]
C. D. Duggan, S. DeMaria, A. Baudhuin, D. Stafford, and J. Ngai
Foxg1 Is Required for Development of the Vertebrate Olfactory System
J. Neurosci., May 14, 2008; 28(20): 5229 - 5239.
[Abstract] [Full Text] [PDF]
N. Ichinohe, A. Knight, M. Ogawa, T. Ohshima, K. Mikoshiba, Y. Yoshihara, T. Terashima, and K. S. Rockland
Unusual Patch-Matrix Organization in the Retrosplenial Cortex of the reeler Mouse and Shaking Rat Kawasaki
Cereb Cortex, May 1, 2008; 18(5): 1125 - 1138.
[Abstract] [Full Text] [PDF]
B. Murdoch and A. J. Roskams
A Novel Embryonic Nestin-Expressing Radial Glia-Like Progenitor Gives Rise to Zonally Restricted Olfactory and Vomeronasal Neurons
J. Neurosci., April 16, 2008; 28(16): 4271 - 4282.
[Abstract] [Full Text] [PDF]
T. Ishii and P. Mombaerts
Expression of Nonclassical Class I Major Histocompatibility Genes Defines a Tripartite Organization of the Mouse Vomeronasal System
J. Neurosci., March 5, 2008; 28(10): 2332 - 2341.
[Abstract] [Full Text] [PDF]
J. H. Cho, M. Lepine, W. Andrews, J. Parnavelas, and J.-F. Cloutier
Requirement for Slit-1 and Robo-2 in Zonal Segregation of Olfactory Sensory Neuron Axons in the Main Olfactory Bulb
J. Neurosci., August 22, 2007; 27(34): 9094 - 9104.
[Abstract] [Full Text] [PDF]
D.-J. Zou, A. T. Chesler, C. E. Le Pichon, A. Kuznetsov, X. Pei, E. L. Hwang, and S. Firestein
Absence of Adenylyl Cyclase 3 Perturbs Peripheral Olfactory Projections in Mice
J. Neurosci., June 20, 2007; 27(25): 6675 - 6683.
[Abstract] [Full Text] [PDF]
E. Feldmesser, D. Bercovich, N. Avidan, S. Halbertal, L. Haim, R. Gross-Isseroff, S. Goshen, and D. Lancet
Mutations in Olfactory Signal Transduction Genes Are Not a Major Cause of Human Congenital General Anosmia
Chem Senses, January 1, 2007; 32(1): 21 - 30.
[Abstract] [Full Text] [PDF]
K. Mori, Y. K. Takahashi, K. M. Igarashi, and M. Yamaguchi
Maps of Odorant Molecular Features in the Mammalian Olfactory Bulb
Physiol Rev, April 1, 2006; 86(2): 409 - 433.
[Abstract] [Full Text] [PDF]
K. Miyamichi, S. Serizawa, H. M. Kimura, and H. Sakano
Continuous and Overlapping Expression Domains of Odorant Receptor Genes in the Olfactory Epithelium Determine the Dorsal/Ventral Positioning of Glomeruli in the Olfactory Bulb
J. Neurosci., April 6, 2005; 25(14): 3586 - 3592.
[Abstract] [Full Text] [PDF]
S.-i. Yoshihara, K. Omichi, M. Yanazawa, K. Kitamura, and Y. Yoshihara
Arx homeobox gene is essential for development of mouse olfactory system
Development, February 15, 2005; 132(4): 751 - 762.
[Abstract] [Full Text] [PDF]
K. M. Igarashi and K. Mori
Spatial Representation of Hydrocarbon Odorants in the Ventrolateral Zones of the Rat Olfactory Bulb
J Neurophysiol, February 1, 2005; 93(2): 1007 - 1019.
[Abstract] [Full Text] [PDF]
N. Miyasaka, Y. Sato, and Y. Yoshihara
Axon Guidance of Olfactory Sensory Neurons in Zebrafish
Chem Senses, January 1, 2005; 30(suppl_1): i92 - i93.
[Full Text] [PDF]
J. S. John and B. Key
A Model for Axon Navigation Based on Glycocodes in the Primary Olfactory System
Chem Senses, January 1, 2005; 30(suppl_1): i123 - i124.
[Full Text] [PDF]
A. Kolterud, M. Alenius, L. Carlsson, and S. Bohm
The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity
Development, November 1, 2004; 131(21): 5319 - 5326.
[Abstract] [Full Text] [PDF]
Y. K. Takahashi, M. Kurosaki, S. Hirono, and K. Mori
Topographic Representation of Odorant Molecular Features in the Rat Olfactory Bulb
J Neurophysiol, October 1, 2004; 92(4): 2413 - 2427.
[Abstract] [Full Text] [PDF]
D. M. Lin, Y. H. Yang, J. A. Scolnick, L. J. Brunet, H. Marsh, V. Peng, Y. Okazaki, Y. Hayashizaki, T. P. Speed, and J. Ngai
Spatial patterns of gene expression in the olfactory bulb
PNAS, August 24, 2004; 101(34): 12718 - 12723.
[Abstract] [Full Text] [PDF]
P. Giacobini, A. S. Kopin, P. M. Beart, L. D. Mercer, A. Fasolo, and S. Wray
Cholecystokinin Modulates Migration of Gonadotropin-Releasing Hormone-1 Neurons
J. Neurosci., May 19, 2004; 24(20): 4737 - 4748.
[Abstract] [Full Text] [PDF]
J. W. Lewcock and R. R. Reed
A feedback mechanism regulates monoallelic odorant receptor expression
PNAS, January 27, 2004; 101(4): 1069 - 1074.
[Abstract] [Full Text] [PDF]
C. L. Iwema, H. Fang, D. B. Kurtz, S. L. Youngentob, and J. E. Schwob
Odorant Receptor Expression Patterns Are Restored in Lesion-Recovered Rat Olfactory Epithelium
J. Neurosci., January 14, 2004; 24(2): 356 - 369.
[Abstract] [Full Text] [PDF]
M. Kaneko and A. Nighorn
Interaxonal Eph-Ephrin Signaling May Mediate Sorting of Olfactory Sensory Axons in Manduca sexta
J. Neurosci., December 17, 2003; 23(37): 11523 - 11538.
[Abstract] [Full Text] [PDF]
A. Hansen, S. H. Rolen, K. Anderson, Y. Morita, J. Caprio, and T. E. Finger
Correlation between Olfactory Receptor Cell Type and Function in the Channel Catfish
J. Neurosci., October 15, 2003; 23(28): 9328 - 9339.
[Abstract] [Full Text] [PDF]
M. Alenius and S. Bohm
Differential function of RNCAM isoforms in precise target selection of olfactory sensory neurons
Development, March 1, 2003; 130(5): 917 - 927.
[Abstract] [Full Text] [PDF]
M. Taniguchi, H. Nagao, Y. K. Takahashi, M. Yamaguchi, S. Mitsui, T. Yagi, K. Mori, and T. Shimizu
Distorted Odor Maps in the Olfactory Bulb of Semaphorin 3A-Deficient Mice
J. Neurosci., February 15, 2003; 23(4): 1390 - 1397.
[Abstract] [Full Text] [PDF]
B. Goetze, H. Breer, and J. Strotmann
A Long-term Culture System for Olfactory Explants with Intrinsically Fluorescent Cell Populations
Chem Senses, November 1, 2002; 27(9): 817 - 824.
[Abstract] [Full Text] [PDF]
A. Walz, I. Rodriguez, and P. Mombaerts
Aberrant Sensory Innervation of the Olfactory Bulb in Neuropilin-2 Mutant Mice
J. Neurosci., May 15, 2002; 22(10): 4025 - 4035.
[Abstract] [Full Text] [PDF]
N. Kinoshita, T. Mizuno, and Y. Yoshihara
Adenovirus-mediated WGA Gene Delivery for Transsynaptic Labeling of Mouse Olfactory Pathways
Chem Senses, March 1, 2002; 27(3): 215 - 223.
[Abstract] [Full Text] [PDF]
B. Key and J. St John
Axon Navigation in the Mammalian Primary Olfactory Pathway: Where to Next?
Chem Senses, March 1, 2002; 27(3): 245 - 260.
[Abstract] [Full Text] [PDF]
M. D. Christensen, E. H. Holbrook, R. M. Costanzo, and J. E. Schwob
Rhinotopy is Disrupted During the Re-innervation of the Olfactory Bulb that Follows Transection of the Olfactory Nerve
Chem Senses, May 1, 2001; 26(4): 359 - 369.
[Abstract] [Full Text] [PDF]
E. B. Little, K. L. Crossin, L. A. Krushel, G. M. Edelman, and B. A. Cunningham
A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes
PNAS, February 15, 2001; (2001) 41597098.
[Abstract] [Full Text]
G. A. Schwarting, C. Kostek, N. Ahmad, C. Dibble, L. Pays, and A. W. Puschel
Semaphorin 3A Is Required for Guidance of Olfactory Axons in Mice
J. Neurosci., October 15, 2000; 20(20): 7691 - 7697.
[Abstract] [Full Text] [PDF]
M.-C. Amoureux, B. A. Cunningham, G. M. Edelman, and K. L. Crossin
N-CAM Binding Inhibits the Proliferation of Hippocampal Progenitor Cells and Promotes Their Differentiation to a Neuronal Phenotype
J. Neurosci., May 15, 2000; 20(10): 3631 - 3640.
[Abstract] [Full Text] [PDF]
J. W. Scott and T. Brierley
A Functional Map in Rat Olfactory Epithelium
Chem Senses, December 1, 1999; 24(6): 679 - 690.
[Abstract] [Full Text] [PDF]
M. Tanaka, H. Treloar, R. G. Kalb, C. A. Greer, and S. M. Strittmatter
Go protein-dependent survival of primary accessory olfactory neurons
PNAS, November 23, 1999; 96(24): 14106 - 14111.
[Abstract] [Full Text] [PDF]
W. Rossler, L. A. Oland, M. R. Higgins, J. G. Hildebrand, and L. P. Tolbert
Development of a Glia-Rich Axon-Sorting Zone in the Olfactory Pathway of the Moth Manduca sexta
J. Neurosci., November 15, 1999; 19(22): 9865 - 9877.
[Abstract] [Full Text] [PDF]
R. J. Pasterkamp, F. De Winter, A. J. G. D. Holtmaat, and J. Verhaagen
Evidence for a Role of the Chemorepellent Semaphorin III and Its Receptor Neuropilin-1 in the Regeneration of Primary Olfactory Axons
J. Neurosci., December 1, 1998; 18(23): 9962 - 9976.
[Abstract] [Full Text] [PDF]
W. J. Dreyer
The area code hypothesis revisited: Olfactory receptors and other related transmembrane receptors may function as the last digits in a cell surface code for assembling embryos
PNAS, August 4, 1998; 95(16): 9072 - 9077.
[Abstract] [Full Text] [PDF]
E. B. Little, K. L. Crossin, L. A. Krushel, G. M. Edelman, and B. A. Cunningham
A short segment within the cytoplasmic domain of the neural cell adhesion molecule (N-CAM) is essential for N-CAM-induced NF-kappa B activity in astrocytes
PNAS, February 27, 2001; 98(5): 2238 - 2243.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|