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Volume 17, Number 15,
Issue of August 1, 1997
pp. 6011-6020
Copyright ©1997 Society for Neuroscience
Excitotoxic Lesions of the Amygdala Fail to Produce Impairment in
Visual Learning for Auditory Secondary Reinforcement But Interfere
with Reinforcer Devaluation Effects in Rhesus Monkeys
Received Feb. 4, 1997; revised April 30, 1997; accepted May 22, 1997.
Ludi e Málková1,
David Gaffan2, and
Elisabeth A. Murray1
1 Laboratory of Neuropsychology, National Institute of
Mental Health, Bethesda, Maryland 20892, and 2 Department
of Experimental Psychology, Oxford University, Oxford OX1 3UD, England,
United Kingdom
Aspiration lesions of the amygdala were found previously to produce
a severe impairment in visual discrimination learning for auditory
secondary reinforcement in rhesus monkeys ().
To determine whether excitotoxic amygdala lesions would also produce
this effect, we trained four naive rhesus monkeys on the same task. The
monkeys were required to learn 40 new visual discrimination problems
per session in a situation in which visual choices were guided by an
auditory secondary reinforcer that had been previously associated with
food reward. Bilateral excitotoxic lesions of the amygdala had no
effect on the rate of learning visual discrimination problems for
auditory secondary reinforcement. We also tested the amygdalectomized
monkeys on a reinforcer devaluation task and compared their performance
with a group of three normal monkeys. The monkeys first learned to discriminate 60 pairs of objects, baited with two different food rewards. Each of the food rewards was then devalued by selective satiation in two separate experimental sessions. Normal controls tended
to avoid displacing objects that covered the devalued food to a
significantly greater degree than did the amygdalectomized monkeys,
indicating that the excitotoxic amygdala damage interfered with
reinforcer devaluation effects. Our results are consistent with the
idea that the amygdala is necessary for learning the association
between stimuli and the value of particular food rewards; however, the
amygdala is not necessary for maintaining the value of secondary
reinforcers, once they have been learned.
Key words:
amygdala;
ibotenic acid;
visual discrimination;
auditory;
secondary reinforcement;
reinforcer devaluation;
rhesus monkey
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