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Volume 17, Number 16, Issue of August 15, 1997 pp. 6409-6423
Copyright ©1997 Society for Neuroscience

Physiology and Plasticity of Morphologically Identified Cells in the Mormyrid Electrosensory Lobe

Received Dec. 12, 1996; revised May 22, 1997; accepted May 28, 1997.

Curtis C. Bell¹, Angel Caputi², and Kirsty Grant³

¹ R. S. Dow Neurological Sciences Institute, Legacy Good Samaritan Hospital and Medical Center, Portland, Oregon 97209, ² Division de Neuroanatomia Comparada, Instituto de Investigaciones Biologicas Clemente Estable, Montevideo, 11600 Uruguay, and ³ Institut Alfred Fessard, Centre National de la Recherche Scientifique, 91190 Gif sur Yvette, France

The electrosensory lobe (ELL) of mormyrid electric fish is the first stage in the central processing of sensory input from electroreceptors. The responses of cells in ELL to electrosensory input are strongly affected by corollary discharge signals associated with the motor command that drives the electric organ discharge (EOD). This study used intracellular recording and staining to describe the physiology of three major cell types in the mormyrid ELL: the medium ganglion cell, the large ganglion cell, and the large fusiform cell. The medium ganglion cell is a Purkinje-like interneuron, whereas the large ganglion and large fusiform cells are efferent neurons that convey electrosensory information to higher stages of the system.

Clear differences were observed among the three cell types. Medium ganglion cells showed two types of spikes, a small narrow spike and a large broad spike that were probably of axonal and dendro-somatic origin, respectively, whereas the large ganglion and large fusiform cells showed only large narrow spikes. Most of the medium ganglion cells and all of the large ganglion cells were inhibited by electrosensory stimuli in the center of their receptive fields, whereas the large fusiform cells were excited by such stimuli.

Responses to the EOD corollary discharge were different in the three cell types, and these responses underwent plastic changes after a few minutes of pairing with an electrosensory stimulus. Plastic changes were also observed in medium and large ganglion cells after the corollary discharge was paired with depolarizing, intracellular current pulses.

Key words: mormyrid; electric fish; electrosensory; cerebellum; plasticity; corollary discharge; efference copy

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