 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 17, Number 17, Issue of September 1, 1997 pp. 6783-6797
Copyright ©1997 Society for NeuroscienceCellular-Synaptic Generation of Sleep Spindles, Spike-and-Wave Discharges, and Evoked Thalamocortical Responses in the Neocortex of the Rat
Received April 23, 1997; revised June 2, 1997; accepted June 16, 1997.
Adam Kandel and György Buzsáki Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102
Thalamocortical neuronal oscillations underlie various field potentials that are expressed in the neocortex, including sleep spindles and high voltage spike-and-wave patterns (HVSs). The mechanism of extracellular current generation in the neocortex was studied in the anesthetized and awake rat. Field potentials and unit activity were recorded simultaneously along trajectories perpendicular to the cortical layers at spatial intervals of 100 µm by multiple-site recording silicon probes. Current source density (CSD) analysis revealed that the spatial positions of sinks in layers IV, V-VI, and II-III and of the accompanying sources were similar during sleep spindles, HVSs, and thalamic-evoked responses, although their relative strengths and timings differed. The magnitude and relative timing of the multiple pairs of sinks and sources determined the amplitude variability of HVSs and sleep spindles. The presence of temporally shifted dipoles was also supported by the time distribution of unit discharges in different layers. Putative interneurons discharged with repetitive bursts of 300-500 Hz. The spike component of HVSs was associated with fast field oscillations (400-600 Hz "ripples"). Discharges of pyramidal cells were phase-locked to the ripples. These findings indicate that the major extracellular currents underlying sleep spindles, HVSs, and evoked responses result from activation of intracortical circuitries. We hypothesize that the fast field ripples reflect summed IPSPs in pyramidal cells resulting from the high frequency barrage of interneurons.
Key words: oscillation; petit mal epilepsy; interneurons; field potential; EEG; membrane currents; thalamocortical system
This article has been cited by other articles:
S. R. Jones, D. L. Pritchett, M. A. Sikora, S. M. Stufflebeam, M. Hamalainen, and C. I. Moore
Quantitative Analysis and Biophysically Realistic Neural Modeling of the MEG Mu Rhythm: Rhythmogenesis and Modulation of Sensory-Evoked Responses
J Neurophysiol, December 1, 2009; 102(6): 3554 - 3572.
[Abstract] [Full Text] [PDF]
G. A. Ojemann, D. P. Corina, N. Corrigan, J. Schoenfield-McNeill, A. Poliakov, L. Zamora, and S. Zanos
Neuronal correlates of functional magnetic resonance imaging in human temporal cortex
Brain, September 22, 2009; (2009) awp227v1.
[Abstract] [Full Text] [PDF]
C. Dejean, C. E. Gross, B. Bioulac, and T. Boraud
Dynamic Changes in the Cortex-Basal Ganglia Network After Dopamine Depletion in the Rat
J Neurophysiol, July 1, 2008; 100(1): 385 - 396.
[Abstract] [Full Text] [PDF]
S. R. Jones, D. L. Pritchett, S. M. Stufflebeam, M. Hamalainen, and C. I. Moore
Neural Correlates of Tactile Detection: A Combined Magnetoencephalography and Biophysically Based Computational Modeling Study
J. Neurosci., October 3, 2007; 27(40): 10751 - 10764.
[Abstract] [Full Text] [PDF]
M. Tsanov and D. Manahan-Vaughan
The Adult Visual Cortex Expresses Dynamic Synaptic Plasticity That Is Driven by the Light/Dark Cycle
J. Neurosci., August 1, 2007; 27(31): 8414 - 8421.
[Abstract] [Full Text] [PDF]
M. Tsanov and D. Manahan-Vaughan
Intrinsic, Light-Independent and Visual Activity-Dependent Mechanisms Cooperate in the Shaping of the Field Response in Rat Visual Cortex
J. Neurosci., August 1, 2007; 27(31): 8422 - 8429.
[Abstract] [Full Text] [PDF]
F. Ferrarelli, R. Huber, M. J. Peterson, M. Massimini, M. Murphy, B. A. Riedner, A. Watson, P. Bria, and G. Tononi
Reduced Sleep Spindle Activity in Schizophrenia Patients
Am J Psychiatry, March 1, 2007; 164(3): 483 - 492.
[Abstract] [Full Text] [PDF]
M. H.P. Kole, A. U. Brauer, and G. J. Stuart
Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model
J. Physiol., January 15, 2007; 578(2): 507 - 525.
[Abstract] [Full Text] [PDF]
K. M. Rodgers, A. M. Benison, and D. S. Barth
Two-Dimensional Coincidence Detection in the Vibrissa/Barrel Field
J Neurophysiol, October 1, 2006; 96(4): 1981 - 1990.
[Abstract] [Full Text] [PDF]
G. Marin, J. Mpdozis, E. Sentis, T. Ossandon, and J. C. Letelier
Oscillatory Bursts in the Optic Tectum of Birds Represent Re-Entrant Signals from the Nucleus Isthmi Pars Parvocellularis
J. Neurosci., July 27, 2005; 25(30): 7081 - 7089.
[Abstract] [Full Text] [PDF]
A. Fontanini and D. B. Katz
7 to 12 Hz Activity in Rat Gustatory Cortex Reflects Disengagement From a Fluid Self-Administration Task
J Neurophysiol, May 1, 2005; 93(5): 2832 - 2840.
[Abstract] [Full Text] [PDF]
R. J. Staba, T. D. Ard, A. M. Benison, and D. S. Barth
Intracortical Pathways Mediate Nonlinear Fast Oscillation (>200 Hz) Interactions Within Rat Barrel Cortex
J Neurophysiol, May 1, 2005; 93(5): 2934 - 2939.
[Abstract] [Full Text] [PDF]
T. J. Blanche, M. A. Spacek, J. F. Hetke, and N. V. Swindale
Polytrodes: High-Density Silicon Electrode Arrays for Large-Scale Multiunit Recording
J Neurophysiol, May 1, 2005; 93(5): 2987 - 3000.
[Abstract] [Full Text] [PDF]
J. R. Gibson, M. Beierlein, and B. W. Connors
Functional Properties of Electrical Synapses Between Inhibitory Interneurons of Neocortical Layer 4
J Neurophysiol, January 1, 2005; 93(1): 467 - 480.
[Abstract] [Full Text] [PDF]
R. Hanajima, R. Chen, P. Ashby, A. M. Lozano, W. D. Hutchison, K. D. Davis, and J. O. Dostrovsky
Very Fast Oscillations Evoked by Median Nerve Stimulation in the Human Thalamus and Subthalamic Nucleus
J Neurophysiol, December 1, 2004; 92(6): 3171 - 3182.
[Abstract] [Full Text] [PDF]
R. J Staba, P. C Bergmann, and D. S Barth
Dissociation of slow waves and fast oscillations above 200 Hz during GABA application in rat somatosensory cortex
J. Physiol., November 15, 2004; 561(1): 205 - 214.
[Abstract] [Full Text] [PDF]
K. F. Ahrens and D. Kleinfeld
Current Flow in Vibrissa Motor Cortex Can Phase-Lock With Exploratory Rhythmic Whisking in Rat
J Neurophysiol, September 1, 2004; 92(3): 1700 - 1707.
[Abstract] [Full Text] [PDF]
F.-Z. Shaw
Is Spontaneous High-Voltage Rhythmic Spike Discharge in Long Evans Rats an Absence-Like Seizure Activity?
J Neurophysiol, January 1, 2004; 91(1): 63 - 77.
[Abstract] [Full Text]
R. Maex and E. De Schutter
Resonant Synchronization in Heterogeneous Networks of Inhibitory Neurons
J. Neurosci., November 19, 2003; 23(33): 10503 - 10514.
[Abstract] [Full Text] [PDF]
J. Csicsvari, D. A. Henze, B. Jamieson, K. D. Harris, A. Sirota, P. Bartho, K. D. Wise, and G. Buzsaki
Massively Parallel Recording of Unit and Local Field Potentials With Silicon-Based Electrodes
J Neurophysiol, August 1, 2003; 90(2): 1314 - 1323.
[Abstract] [Full Text] [PDF]
N. Brunel and X.-J. Wang
What Determines the Frequency of Fast Network Oscillations With Irregular Neural Discharges? I. Synaptic Dynamics and Excitation-Inhibition Balance
J Neurophysiol, July 1, 2003; 90(1): 415 - 430.
[Abstract] [Full Text] [PDF]
N. K. Logothetis
The Underpinnings of the BOLD Functional Magnetic Resonance Imaging Signal
J. Neurosci., May 15, 2003; 23(10): 3963 - 3971.
[Full Text] [PDF]
R. J. Staba, B. Brett-Green, M. Paulsen, and D. S. Barth
Effects of Ventrobasal Lesion and Cortical Cooling on Fast Oscillations (>200 Hz) in Rat Somatosensory Cortex
J Neurophysiol, May 1, 2003; 89(5): 2380 - 2388.
[Abstract] [Full Text] [PDF]
D. S. Barth
Submillisecond Synchronization of Fast Electrical Oscillations in Neocortex
J. Neurosci., March 15, 2003; 23(6): 2502 - 2510.
[Abstract] [Full Text] [PDF]
D. L. Buhl, K. D. Harris, S. G. Hormuzdi, H. Monyer, and G. Buzsaki
Selective Impairment of Hippocampal Gamma Oscillations in Connexin-36 Knock-Out Mouse In Vivo
J. Neurosci., February 1, 2003; 23(3): 1013 - 1018.
[Abstract] [Full Text] [PDF]
R. J. Staba, C. L. Wilson, A. Bragin, I. Fried, and J. Engel Jr
Quantitative Analysis of High-Frequency Oscillations (80-500 Hz) Recorded in Human Epileptic Hippocampus and Entorhinal Cortex
J Neurophysiol, October 1, 2002; 88(4): 1743 - 1752.
[Abstract] [Full Text] [PDF]
M. S. Jones and D. S. Barth
Effects of Bicuculline Methiodide on Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex
J Neurophysiol, August 1, 2002; 88(2): 1016 - 1025.
[Abstract] [Full Text] [PDF]
I. Timofeev, F. Grenier, M. Bazhenov, A. R Houweling, T. J Sejnowski, and M. Steriade
Short- and medium-term plasticity associated with augmenting responses in cortical slabs and spindles in intact cortex of cats in vivo
J. Physiol., July 15, 2002; 542(2): 583 - 598.
[Abstract] [Full Text] [PDF]
A. R Houweling, M. Bazhenov, I. Timofeev, F. Grenier, M. Steriade, and T. J Sejnowski
Frequency-selective augmenting responses by short-term synaptic depression in cat neocortex
J. Physiol., July 15, 2002; 542(2): 599 - 617.
[Abstract] [Full Text] [PDF]
M. A Castro-Alamancos and E. Oldford
Cortical sensory suppression during arousal is due to the activity-dependent depression of thalamocortical synapses
J. Physiol., May 15, 2002; 541(1): 319 - 331.
[Abstract] [Full Text] [PDF]
A. Bragin, I. Mody, C. L. Wilson, and J. Engel Jr
Local Generation of Fast Ripples in Epileptic Brain
J. Neurosci., March 1, 2002; 22(5): 2012 - 2021.
[Abstract] [Full Text] [PDF]
H. K. M. Meeren, J. P. M. Pijn, E. L. J. M. Van Luijtelaar, A. M. L. Coenen, and F. H. Lopes da Silva
Cortical Focus Drives Widespread Corticothalamic Networks during Spontaneous Absence Seizures in Rats
J. Neurosci., February 15, 2002; 22(4): 1480 - 1495.
[Abstract] [Full Text] [PDF]
F. Grenier, I. Timofeev, and M. Steriade
Focal Synchronization of Ripples (80-200 Hz) in Neocortex and Their Neuronal Correlates
J Neurophysiol, October 1, 2001; 86(4): 1884 - 1898.
[Abstract] [Full Text] [PDF]
Y. Kawaguchi
Distinct Firing Patterns of Neuronal Subtypes in Cortical Synchronized Activities
J. Neurosci., September 15, 2001; 21(18): 7261 - 7272.
[Abstract] [Full Text] [PDF]
M. Steriade
Impact of Network Activities on Neuronal Properties in Corticothalamic Systems
J Neurophysiol, July 1, 2001; 86(1): 1 - 39.
[Abstract] [Full Text] [PDF]
S. Ogawa, T.-M. Lee, R. Stepnoski, W. Chen, X.-H. Zhu, and K. Ugurbil
An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds
PNAS, September 26, 2000; 97(20): 11026 - 11031.
[Abstract] [Full Text] [PDF]
M. S. Jones, K. D. MacDonald, B. Choi, F. E. Dudek, and D. S. Barth
Intracellular Correlates of Fast (>200 Hz) Electrical Oscillations in Rat Somatosensory Cortex
J Neurophysiol, September 1, 2000; 84(3): 1505 - 1518.
[Abstract] [Full Text] [PDF]
F. Amzica and M. Steriade
Neuronal and Glial Membrane Potentials during Sleep and Paroxysmal Oscillations in the Neocortex
J. Neurosci., September 1, 2000; 20(17): 6648 - 6665.
[Abstract] [Full Text] [PDF]
H. Blumenfeld and D. A. McCormick
Corticothalamic Inputs Control the Pattern of Activity Generated in Thalamocortical Networks
J. Neurosci., July 1, 2000; 20(13): 5153 - 5162.
[Abstract] [Full Text] [PDF]
J. C. Prechtl, T. H. Bullock, and D. Kleinfeld
Direct evidence for local oscillatory current sources and intracortical phase gradients in turtle visual cortex
PNAS, January 18, 2000; 97(2): 877 - 882.
[Abstract] [Full Text] [PDF]
M. Steriade and F. Amzica
Intracellular Study of Excitability in the Seizure-Prone Neocortex In Vivo
J Neurophysiol, December 1, 1999; 82(6): 3108 - 3122.
[Abstract] [Full Text] [PDF]
M. A. Kisley and G. L. Gerstein
Trial-to-Trial Variability and State-Dependent Modulation of Auditory-Evoked Responses in Cortex
J. Neurosci., December 1, 1999; 19(23): 10451 - 10460.
[Abstract] [Full Text] [PDF]
M. S. Jones and D. S. Barth
Spatiotemporal Organization of Fast (>200 Hz) Electrical Oscillations in Rat Vibrissa/Barrel Cortex
J Neurophysiol, September 1, 1999; 82(3): 1599 - 1609.
[Abstract] [Full Text] [PDF]
M. Steriade and D. Contreras
Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. I. Role of Neocortex and Thalamus
J Neurophysiol, September 1, 1998; 80(3): 1439 - 1455.
[Abstract] [Full Text] [PDF]
M. Steriade, F. Amzica, D. Neckelmann, and I. Timofeev
Spike-Wave Complexes and Fast Components of Cortically Generated Seizures. II. Extra- and Intracellular Patterns
J Neurophysiol, September 1, 1998; 80(3): 1456 - 1479.
[Abstract] [Full Text] [PDF]
M. J. Hartmann and J. M. Bower
Oscillatory Activity in the Cerebellar Hemispheres of Unrestrained Rats
J Neurophysiol, September 1, 1998; 80(3): 1598 - 1604.
[Abstract] [Full Text] [PDF]
M. Steriade, I. Timofeev, F. Grenier, and N. Durmuller
Role of Thalamic and Cortical Neurons in Augmenting Responses and Self-Sustained Activity: Dual Intracellular Recordings In Vivo
J. Neurosci., August 15, 1998; 18(16): 6425 - 6443.
[Abstract] [Full Text] [PDF]
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Computational Models of Thalamocortical Augmenting Responses
J. Neurosci., August 15, 1998; 18(16): 6444 - 6465.
[Abstract] [Full Text] [PDF]
M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski
Cellular and Network Models for Intrathalamic Augmenting Responses During 10-Hz Stimulation
J Neurophysiol, May 1, 1998; 79(5): 2730 - 2748.
[Abstract] [Full Text] [PDF]
G. Buzsaki and A. Kandel
Somadendritic Backpropagation of Action Potentials in Cortical Pyramidal Cells of the Awake Rat
J Neurophysiol, March 1, 1998; 79(3): 1587 - 1591.
[Abstract] [Full Text] [PDF]
J. Csicsvari, H. Hirase, A. Czurko, A. Mamiya, and G. Buzsaki
Fast Network Oscillations in the Hippocampal CA1 Region of the Behaving Rat
J. Neurosci., August 15, 1999; 19(16): RC20 - RC20.
[Abstract] [Full Text] [PDF]
M. A. Castro-Alamancos
Neocortical Synchronized Oscillations Induced by Thalamic Disinhibition In Vivo
J. Neurosci., September 15, 1999; 19(18): RC27 - RC27.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|