 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
Volume 17, Number 18, Issue of September 15, 1997 pp. 6952-6960
Copyright ©1997 Society for NeuroscienceInvolvement of Sphingosine 1-Phosphate in Nerve Growth Factor-Mediated Neuronal Survival and Differentiation
Received March 7, 1997; revised June 12, 1997; accepted June 27, 1997.
Lisa Cseh Edsall, Grisha G. Pirianov, and Sarah Spiegel Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007
Sphingolipid metabolites, such as ceramide and sphingosine-1-phosphate (SPP), are emerging as a new class of second messengers involved in cellular proliferation, differentiation, and apoptosis. Nerve growth factor (NGF), a neurotrophic factor for pheochromocytoma PC12 cells, induced a biphasic increase in the activity of sphingosine kinase, the enzyme that catalyzes the formation of SPP. This activation was blocked by K252a, an inhibitor of tyrosine kinase A (trkA). A rapid 1.7-fold increase was followed by a marked prolonged increase reaching a maximum of fourfold to fivefold stimulation with a concomitant increase in SPP levels and a corresponding decrease in endogenous sphingosine levels. Levels of ceramide, the precursor of sphingosine, were only slightly decreased by NGF in serum-containing medium. However, NGF decreased the elevation of ceramide induced by serum withdrawal. Treatment of PC12 cells with SPP did not induce neurite outgrowth or neurofilament expression, yet it enhanced neurofilament expression elicited by suboptimal doses of NGF. Moreover, SPP also protected PC12 cells from apoptosis induced by serum withdrawal. To further substantiate a role for SPP in the cytoprotective actions of NGF, we found that N,N-dimethylsphingosine, a competitive inhibitor of sphingosine kinase, also induced apoptosis and interfered with the survival effect of NGF. These effects were counteracted by exogenous SPP. Moreover, other structurally related compounds, such as dihydrosphingosine 1-phosphate and lysophosphatidic acid, had no significant protective effects. Our results suggest that activation of sphingosine kinase and subsequent formation of SPP may play an important role in the differentiation and survival effects induced by NGF.
Key words: NGF; sphingolipid metabolites; sphingosine 1-phosphate; apoptosis; neuronal differentiation; trkA; signal transduction
This article has been cited by other articles:
S. G. Laychock, S. M. Sessanna, M.-H. Lin, and L. D. Mastrandrea
Sphingosine 1-Phosphate Affects Cytokine-Induced Apoptosis in Rat Pancreatic Islet {beta}-Cells
Endocrinology, October 1, 2006; 147(10): 4705 - 4712.
[Abstract] [Full Text] [PDF]
V. Pernet and A. Di Polo
Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo
Brain, April 1, 2006; 129(4): 1014 - 1026.
[Abstract] [Full Text] [PDF]
J. S. Kang, Y. D. Yoon, M. H. Han, S.-B. Han, K. Lee, K. H. Lee, S.-K. Park, and H. M. Kim
Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-{alpha}-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-{kappa}B/Rel Signaling Pathways
Mol. Pharmacol., March 1, 2006; 69(3): 941 - 949.
[Abstract] [Full Text] [PDF]
R. V. Stahelin, J. H. Hwang, J.-H. Kim, Z.-Y. Park, K. R. Johnson, L. M. Obeid, and W. Cho
The Mechanism of Membrane Targeting of Human Sphingosine Kinase 1
J. Biol. Chem., December 30, 2005; 280(52): 43030 - 43038.
[Abstract] [Full Text] [PDF]
K. R. Johnson, K. Y. Johnson, H. G. Crellin, B. Ogretmen, A. M. Boylan, R. A. Harley, and L. M. Obeid
Immunohistochemical Distribution of Sphingosine Kinase 1 in Normal and Tumor Lung Tissue
J. Histochem. Cytochem., September 1, 2005; 53(9): 1159 - 1166.
[Abstract] [Full Text] [PDF]
Y. Kariya, A. Kihara, M. Ikeda, F. Kikuchi, S. Nakamura, S. Hashimoto, C.-H. Choi, Y.-M. Lee, and Y. Igarashi
Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis
Genes Cells, June 1, 2005; 10(6): 605 - 615.
[Abstract] [Full Text] [PDF]
L. D. Mastrandrea, S. M. Sessanna, and S. G. Laychock
Sphingosine Kinase Activity and Sphingosine-1 Phosphate Production in Rat Pancreatic Islets and INS-1 Cells: Response to Cytokines
Diabetes, May 1, 2005; 54(5): 1429 - 1436.
[Abstract] [Full Text] [PDF]
V. Limaye, X. Li, C. Hahn, P. Xia, M. C. Berndt, M. A. Vadas, and J. R. Gamble
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members
Blood, April 15, 2005; 105(8): 3169 - 3177.
[Abstract] [Full Text] [PDF]
D. Fischer, V. Petkova, S. Thanos, and L. I. Benowitz
Switching Mature Retinal Ganglion Cells to a Robust Growth State In Vivo: Gene Expression and Synergy with RhoA Inactivation
J. Neurosci., October 6, 2004; 24(40): 8726 - 8740.
[Abstract] [Full Text] [PDF]
N. Urtz, A. Olivera, E. Bofill-Cardona, R. Csonga, A. Billich, D. Mechtcheriakova, F. Bornancin, M. Woisetschlager, J. Rivera, and T. Baumruker
Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to Fc{varepsilon}RI Are Mediated by Its Interaction with Lyn Kinase
Mol. Cell. Biol., October 1, 2004; 24(19): 8765 - 8777.
[Abstract] [Full Text] [PDF]
W. Wu, R. D. Mosteller, and D. Broek
Sphingosine Kinase Protects Lipopolysaccharide-Activated Macrophages from Apoptosis
Mol. Cell. Biol., September 1, 2004; 24(17): 7359 - 7369.
[Abstract] [Full Text] [PDF]
R. E. Toman, S. G. Payne, K. R. Watterson, M. Maceyka, N. H. Lee, S. Milstien, J. W. Bigbee, and S. Spiegel
Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension
J. Cell Biol., August 2, 2004; 166(3): 381 - 392.
[Abstract] [Full Text] [PDF]
M.-T. Park, J.-A Choi, M.-J. Kim, H.-D. Um, S. Bae, C.-M. Kang, C.-K. Cho, S. Kang, H. Y. Chung, Y.-S. Lee, et al.
Suppression of Extracellular Signal-related Kinase and Activation of p38 MAPK Are Two Critical Events Leading to Caspase-8- and Mitochondria-mediated Cell Death in Phytosphingosine-treated Human Cancer Cells
J. Biol. Chem., December 12, 2003; 278(50): 50624 - 50634.
[Abstract] [Full Text] [PDF]
H. Liu, R. E. Toman, S. K. Goparaju, M. Maceyka, V. E. Nava, H. Sankala, S. G. Payne, M. Bektas, I. Ishii, J. Chun, et al.
Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis
J. Biol. Chem., October 10, 2003; 278(41): 40330 - 40336.
[Abstract] [Full Text] [PDF]
K. Itagaki and C. J. Hauser
Sphingosine 1-Phosphate, a Diffusible Calcium Influx Factor Mediating Store-operated Calcium Entry
J. Biol. Chem., July 18, 2003; 278(30): 27540 - 27547.
[Abstract] [Full Text] [PDF]
A. C. Yopp, G. J. Randolph, and J. S. Bromberg
Leukotrienes, Sphingolipids, and Leukocyte Trafficking
J. Immunol., July 1, 2003; 171(1): 5 - 10.
[Full Text] [PDF]
A. Kihara, M. Ikeda, Y. Kariya, E.-Y. Lee, Y.-M. Lee, and Y. Igarashi
Sphingosine-1-phosphate Lyase Is Involved in the Differentiation of F9 Embryonal Carcinoma Cells to Primitive Endoderm
J. Biol. Chem., April 11, 2003; 278(16): 14578 - 14585.
[Abstract] [Full Text] [PDF]
X. Shu, W. Wu, R. D. Mosteller, and D. Broek
Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases
Mol. Cell. Biol., November 15, 2002; 22(22): 7758 - 7768.
[Abstract] [Full Text] [PDF]
H. Le Stunff, I. Galve-Roperh, C. Peterson, S. Milstien, and S. Spiegel
Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
J. Cell Biol., September 16, 2002; 158(6): 1039 - 1049.
[Abstract] [Full Text] [PDF]
K. R. Johnson, K. P. Becker, M. M. Facchinetti, Y. A. Hannun, and L. M. Obeid
PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane. EXTRACELLULAR RELEASE OF SPHINGOSINE-1-PHOSPHATE INDUCED BY PHORBOL 12-MYRISTATE 13-ACETATE (PMA)
J. Biol. Chem., September 13, 2002; 277(38): 35257 - 35262.
[Abstract] [Full Text] [PDF]
E. Lacana, M. Maceyka, S. Milstien, and S. Spiegel
Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity
J. Biol. Chem., August 30, 2002; 277(36): 32947 - 32953.
[Abstract] [Full Text] [PDF]
S. Spiegel and S. Milstien
Sphingosine 1-Phosphate, a Key Cell Signaling Molecule
J. Biol. Chem., July 12, 2002; 277(29): 25851 - 25854.
[Full Text] [PDF]
T.-Y. Chin, H.-M. Hwang, and S.-H. Chueh
Distinct Effects of Different Calcium-Mobilizing Agents on Cell Death in NG108-15 Neuroblastoma X Glioma Cells
Mol. Pharmacol., March 1, 2002; 61(3): 486 - 494.
[Abstract] [Full Text] [PDF]
H. M. ROSENFELDT, J. P. HOBSON, M. MACEYKA, A. OLIVERA, V. E. NAVA, S. MILSTIEN, and S. SPIEGEL
EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
FASEB J, December 1, 2001; 15(14): 2649 - 2659.
[Abstract] [Full Text] [PDF]
S. S. Castillo and D. Teegarden
Ceramide Conversion to Sphingosine-1-Phosphate is Essential for Survival in C3H10T1/2 Cells
J. Nutr., November 1, 2001; 131(11): 2826 - 2830.
[Abstract] [Full Text] [PDF]
O. Cuvillier and T. Levade
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria
Blood, November 1, 2001; 98(9): 2828 - 2836.
[Abstract] [Full Text] [PDF]
T. Murate, Y. Banno, K. T-Koizumi, K. Watanabe, N. Mori, A. Wada, Y. Igarashi, A. Takagi, T. Kojima, H. Asano, et al.
Cell Type-specific Localization of Sphingosine Kinase 1a in Human Tissues
J. Histochem. Cytochem., July 1, 2001; 49(7): 845 - 856.
[Abstract] [Full Text] [PDF]
Y. Xu, Y.-j. Xiao, L. M. Baudhuin, and B. M. Schwartz
The Role and Clinical Applications of Bioactive Lysolipids in Ovarian Cancer
Reproductive Sciences, January 1, 2001; 8(1): 1 - 13.
[Abstract] [PDF]
V. E. Nava, O. Cuvillier, L. C. Edsall, K. Kimura, S. Milstien, E. P. Gelmann, and S. Spiegel
Sphingosine Enhances Apoptosis of Radiation-resistant Prostate Cancer Cells
Cancer Res., August 1, 2000; 60(16): 4468 - 4474.
[Abstract] [Full Text]
S. M. Mandala, R. Thornton, I. Galve-Roperh, S. Poulton, C. Peterson, A. Olivera, J. Bergstrom, M. B. Kurtz, and S. Spiegel
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
PNAS, June 14, 2000; (2000) 120146897.
[Abstract] [Full Text]
D.-S. Im, C. E. Heise, N. Ancellin, B. F. O'Dowd, G.-j. Shei, R. P. Heavens, M. R. Rigby, T. Hla, S. Mandala, G. McAllister, et al.
Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8
J. Biol. Chem., May 5, 2000; 275(19): 14281 - 14286.
[Abstract] [Full Text] [PDF]
F. Wang, J. R. Van Brocklyn, L. Edsall, V. E. Nava, and S. Spiegel
Sphingosine-1-phosphate Inhibits Motility of Human Breast Cancer Cells Independently of Cell Surface Receptors
Cancer Res., December 1, 1999; 59(24): 6185 - 6191.
[Abstract] [Full Text] [PDF]
A. Olivera, T. Kohama, L. Edsall, V. Nava, O. Cuvillier, S. Poulton, and S. Spiegel
Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-phosphate and Promotes Cell Growth and Survival
J. Cell Biol., November 1, 1999; 147(3): 545 - 558.
[Abstract] [Full Text] [PDF]
R. T. Windh, M.-J. Lee, T. Hla, S. An, A. J. Barr, and D. R. Manning
Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins
J. Biol. Chem., September 24, 1999; 274(39): 27351 - 27358.
[Abstract] [Full Text] [PDF]
A. OLIVERA, L. EDSALL, S. POULTON, A. KAZLAUSKAS, and S. SPIEGEL
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLC{gamma}
FASEB J, September 1, 1999; 13(12): 1593 - 1600.
[Abstract] [Full Text]
N. Auge, M. Nikolova-Karakashian, S. Carpentier, S. Parthasarathy, A. Negre-Salvayre, R. Salvayre, A. H. Merrill Jr., and T. Levade
Role of Sphingosine 1-Phosphate in the Mitogenesis Induced by Oxidized Low Density Lipoprotein in Smooth Muscle Cells via Activation of Sphingomyelinase, Ceramidase, and Sphingosine Kinase
J. Biol. Chem., July 30, 1999; 274(31): 21533 - 21538.
[Abstract] [Full Text] [PDF]
J. A. Weiner and J. Chun
Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid
PNAS, April 27, 1999; 96(9): 5233 - 5238.
[Abstract] [Full Text] [PDF]
C. H. Liu, S. Thangada, M.-J. Lee, J. R. Van Brocklyn, S. Spiegel, and T. Hla
Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1
Mol. Biol. Cell, April 1, 1999; 10(4): 1179 - 1190.
[Abstract] [Full Text]
J. R. Van Brocklyn, Z. Tu, L. C. Edsall, R. R. Schmidt, and S. Spiegel
Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218
J. Biol. Chem., February 19, 1999; 274(8): 4626 - 4632.
[Abstract] [Full Text] [PDF]
T. Kohama, A. Olivera, L. Edsall, M. M. Nagiec, R. Dickson, and S. Spiegel
Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase
J. Biol. Chem., September 11, 1998; 273(37): 23722 - 23728.
[Abstract] [Full Text] [PDF]
J. R. Van Brocklyn, M.-J. Lee, R. Menzeleev, A. Olivera, L. Edsall, O. Cuvillier, D. M. Thomas, P. J.P. Coopman, S. Thangada, C. H. Liu, et al.
Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival
J. Cell Biol., July 13, 1998; 142(1): 229 - 240.
[Abstract] [Full Text] [PDF]
A. Olivera, T. Kohama, Z. Tu, S. Milstien, and S. Spiegel
Purification and Characterization of Rat Kidney Sphingosine Kinase
J. Biol. Chem., May 15, 1998; 273(20): 12576 - 12583.
[Abstract] [Full Text] [PDF]
S. O. Yoon, P. Casaccia-Bonnefil, B. Carter, and M. V. Chao
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
J. Neurosci., May 1, 1998; 18(9): 3273 - 3281.
[Abstract] [Full Text] [PDF]
O. Cuvillier, L. Edsall, and S. Spiegel
Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells
J. Biol. Chem., May 19, 2000; 275(21): 15691 - 15700.
[Abstract] [Full Text] [PDF]
H. Liu, M. Sugiura, V. E. Nava, L. C. Edsall, K. Kono, S. Poulton, S. Milstien, T. Kohama, and S. Spiegel
Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform
J. Biol. Chem., June 23, 2000; 275(26): 19513 - 19520.
[Abstract] [Full Text] [PDF]
S. M. Pitson, P. A. B. Moretti, J. R. Zebol, P. Xia, J. R. Gamble, M. A. Vadas, R. J. D'Andrea, and B. W. Wattenberg
Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation. A DOMINANT-NEGATIVE SPHINGOSINE KINASE
J. Biol. Chem., October 20, 2000; 275(43): 33945 - 33950.
[Abstract] [Full Text] [PDF]
E. P. de Chaves, M. Bussiere, B. MacInnis, D. E. Vance, R. B. Campenot, and J. E. Vance
Ceramide Inhibits Axonal Growth and Nerve Growth Factor Uptake without Compromising the Viability of Sympathetic Neurons
J. Biol. Chem., September 21, 2001; 276(39): 36207 - 36214.
[Abstract] [Full Text] [PDF]
S. M. Mandala, R. Thornton, I. Galve-Roperh, S. Poulton, C. Peterson, A. Olivera, J. Bergstrom, M. B. Kurtz, and S. Spiegel
Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death
PNAS, July 5, 2000; 97(14): 7859 - 7864.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|