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Volume 17, Number 18, Issue of September 15, 1997 pp. 7053-7059
Copyright ©1997 Society for Neuroscience

Abeta Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

Received April 4, 1997; revised June 4, 1997; accepted July 1, 1997.

Michael C. Irizarry1, Ferdie Soriano2, Megan McNamara1, Keith J. Page1, Dale Schenk2, Dora Games2, and Bradley T. Hyman1

1 Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, 02114 and 2 Athena Neurosciences, South San Francisco, California 94080

The PDAPP transgenic mouse overexpresses human amyloid precursor protein V717F (PDAPP minigene) and develops age-related cerebral amyloid-beta protein (Abeta ) deposits similar to senile plaques in Alzheimer's disease. We find age-related cortical and limbic Abeta deposition that begins at 8 months and progresses to cover 20-50% of the neuropil in cingulate cortex, entorhinal cortex, and hippocampus of 18-month-old heterozygotic animals. The regional patterns of transgene expression and amyloid deposition suggest that Abeta deposits occur at the terminals of overexpressing neurons. Amyloid deposition is associated with dystrophic neurites and extensive gliosis. However, stereological analysis shows that there is no overt neuronal loss in entorhinal cortex, CA1 hippocampal subfield, or cingulate cortex through 18 months of age. In addition, there is no apparent loss of mRNA encoding neuronal synaptic, cytoskeletal, or metabolic proteins. Thus, widespread Abeta deposition in 18-month-old heterozygotic mice produces neuritic alterations and gliosis without widespread neuronal death.

Key words: transgenic mice; Alzheimer's disease; hippocampus; amyloid; amyloid precursor protein; cingulate cortex; entorhinal cortex; neuritic dystrophy; synaptophysin; microtubule associated protein-2; cytochrome oxidase; glial fibrillary acidic protein




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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Neurology, June 25, 2002; 58(12): 1791 - 1800.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Am. J. Pathol., September 1, 2001; 159(3): 1061 - 1068.
[Abstract] [Full Text] [PDF]

Home page
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J. Neurosci., June 15, 2001; 21(12): 4125 - 4133.
[Abstract] [Full Text] [PDF]

Home page
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Am. J. Pathol., January 1, 2001; 158(1): 173 - 177.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
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Attenuated Host Resistance against Mycobacterium bovis BCG Infection in Mice Lacking Osteopontin
Infect. Immun., August 1, 1999; 67(8): 4223 - 4230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
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Presence of Sodium Dodecyl Sulfate-Stable Amyloid {beta}-Protein Dimers in the Hippocampus CA1 Not Exhibiting Neurofibrillary Tangle Formation
Am. J. Pathol., July 1, 1999; 155(1): 23 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
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Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice
Am. J. Pathol., June 1, 1999; 154(6): 1673 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
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PNAS, April 27, 1999; 96(9): 5274 - 5279.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Y. Hsia, E. Masliah, L. McConlogue, G.-Q. Yu, G. Tatsuno, K. Hu, D. Kholodenko, R. C. Malenka, R. A. Nicoll, and L. Mucke
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
PNAS, March 16, 1999; 96(6): 3228 - 3233.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Moechars, I. Dewachter, K. Lorent, D. Reverse, V. Baekelandt, A. Naidu, I. Tesseur, K. Spittaels, C. V. D. Haute, F. Checler, et al.
Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain
J. Biol. Chem., March 5, 1999; 274(10): 6483 - 6492.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Goedert and M. Hasegawa
The Tauopathies : Toward an Experimental Animal Model
Am. J. Pathol., January 1, 1999; 154(1): 1 - 6.
[Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Enya, M. Morishima-Kawashima, M. Yoshimura, Y. Shinkai, K. Kusui, K. Khan, D. Games, D. Schenk, S. Sugihara, H. Yamaguchi, et al.
Appearance of Sodium Dodecyl Sulfate-Stable Amyloid ß-Protein (Aß) Dimer in the Cortex During Aging
Am. J. Pathol., January 1, 1999; 154(1): 271 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. R. PICCIOTTO and K. WICKMAN
Using Knockout and Transgenic Mice to Study Neurophysiology and Behavior
Physiol Rev, October 1, 1998; 78(4): 1131 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. H. Smith, M. Nakamura, T. K. McIntosh, J. Wang, A. Rodriguez, X.-H. Chen, R. Raghupathi, K. E. Saatman, J. Clemens, M. L. Schmidt, et al.
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Am. J. Pathol., September 1, 1998; 153(3): 1005 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Nishimura, T. Uetsuki, S. U. Dani, Y. Ohsawa, I. Saito, H. Okamura, Y. Uchiyama, and K. Yoshikawa
Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer
J. Neurosci., April 1, 1998; 18(7): 2387 - 2398.
[Abstract] [Full Text] [PDF]

Home page
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Science, October 17, 1997; 278(5337): 412 - 419.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Y. Yoshiike, K. Tanemura, O. Murayama, T. Akagi, M. Murayama, S. Sato, X. Sun, N. Tanaka, and A. Takashima
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J. Biol. Chem., August 17, 2001; 276(34): 32293 - 32299.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
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J. Biol. Chem., June 8, 2001; 276(24): 21562 - 21570.
[Abstract] [Full Text] [PDF]

Home page
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