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Previous Article | Next Article
Volume 17, Number 19, Issue of October 1, 1997 pp. 7503-7522
Copyright ©1997 Society for NeuroscienceDifferential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus
Received March 28, 1997; revised July 14, 1997; accepted July 16, 1997.
Ryuichi Shigemoto1, Ayae Kinoshita1, Eiki Wada1, Sakashi Nomura3, Hitoshi Ohishi1, Masahiko Takada1, Peter J. Flor4, Akio Neki2, Takaaki Abe2, Shigetada Nakanishi2, and Noboru Mizuno1 Departments of 1 Morphological Brain Science and 2 Biological Sciences,
Faculty of Medicine, and 3 College of Medical Technology, Kyoto University, Kyoto 606, Japan, and 4 Novartis Pharma Inc., Nervous System Research, CH-4002 Basel, Switzerland Neurotransmission in the hippocampus is modulated variously through presynaptic metabotropic glutamate receptors (mGluRs). To establish the precise localization of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning of the three major hippocampal pathways: the perforant path, mossy fiber, and Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a, mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to postsynaptic elements. The medial perforant path was strongly immunoreactive for mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The mossy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer collateral was labeled only for mGluR7a. Electron microscopy further revealed the spatial segregation of group II and group III mGluRs within presynaptic elements. Immunolabeling for the group III receptors was predominantly observed in presynaptic active zones of asymmetrical and symmetrical synapses, whereas that for the group II receptor (mGluR2) was found in preterminal rather than terminal portions of axons. Target cell-specific segregation of receptors, first reported for mGluR7a (), was also apparent for the other group III mGluRs, suggesting that transmitter release is differentially regulated by 2-amino-4-phosphonobutyrate-sensitive mGluRs in individual synapses on single axons according to the identity of postsynaptic neurons.
Key words: metabotropic glutamate receptor; hippocampus; perforant path; mossy fiber; Schaffer collateral; axon terminal; preterminal; immunohistochemistry; lesion
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PNAS, January 22, 2002; 99(2): 1041 - 1046.
[Abstract] [Full Text] [PDF]
G. Sansig, T. J. Bushell, V. R. J. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, et al.
Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7
J. Neurosci., November 15, 2001; 21(22): 8734 - 8745.
[Abstract] [Full Text] [PDF]
D. D. Schoepp
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
J. Pharmacol. Exp. Ther., October 1, 2001; 299(1): 12 - 20.
[Abstract] [Full Text] [PDF]
G. Mannaioni, M. J. Marino, O. Valenti, S. F. Traynelis, and P. J. Conn
Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function
J. Neurosci., August 15, 2001; 21(16): 5925 - 5934.
[Abstract] [Full Text] [PDF]
J.-y. Lan, V. A. Skeberdis, T. Jover, X. Zheng, M. V. L. Bennett, and R. S. Zukin
Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking
J. Neurosci., August 15, 2001; 21(16): 6058 - 6068.
[Abstract] [Full Text] [PDF]
M. Mori, C. Heuss, B. H Gahwiler, and U. Gerber
Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures
J. Physiol., August 15, 2001; 535(1): 115 - 123.
[Abstract] [Full Text] [PDF]
R. A. Wright, M. B. Arnold, W. J. Wheeler, P. L. Ornstein, and D. D. Schoepp
[3H]LY341495 Binding to Group II Metabotropic Glutamate Receptors in Rat Brain
J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 453 - 460.
[Abstract] [Full Text] [PDF]
J. Pamidimukkala and M. Hay
Frequency dependence of endocytosis in aortic baroreceptor neurons and role of group III mGluRs
Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H387 - H395.
[Abstract] [Full Text] [PDF]
J. Kilbride, A. M. Rush, M. J. Rowan, and R. Anwyl
Presynaptic Group II mGluR Inhibition of Short-Term Depression in the Medial Perforant Path of the Dentate Gyrus In Vitro
J Neurophysiol, June 1, 2001; 85(6): 2509 - 2515.
[Abstract] [Full Text] [PDF]
E Jankowska
Spinal interneuronal systems: identification, multifunctional character and reconfigurations in mammals
J. Physiol., May 15, 2001; 533(1): 31 - 40.
[Abstract] [Full Text] [PDF]
C. E. Gee, G. Woodhall, and J.-C. Lacaille
Synaptically Activated Calcium Responses in Dendrites of Hippocampal Oriens-Alveus Interneurons
J Neurophysiol, April 1, 2001; 85(4): 1603 - 1613.
[Abstract] [Full Text] [PDF]
C. A. Reid, R. Fabian-Fine, and A. Fine
Postsynaptic Calcium Transients Evoked by Activation of Individual Hippocampal Mossy Fiber Synapses
J. Neurosci., April 1, 2001; 21(7): 2206 - 2214.
[Abstract] [Full Text] [PDF]
P. M. L. IV, B. Wroblewska, J. M. Sarvey, and J. H. Neale
{beta}-NAAG Rescues LTP From Blockade by NAAG in Rat Dentate Gyrus via the Type 3 Metabotropic Glutamate Receptor
J Neurophysiol, March 1, 2001; 85(3): 1097 - 1106.
[Abstract] [Full Text] [PDF]
G. B. Awatramani and M. M. Slaughter
Intensity-Dependent, Rapid Activation of Presynaptic Metabotropic Glutamate Receptors at a Central Synapse
J. Neurosci., January 15, 2001; 21(2): 741 - 749.
[Abstract] [Full Text] [PDF]
V. Neugebauer, P.-S. Chen, and W. D. Willis
Groups II and III Metabotropic Glutamate Receptors Differentially Modulate Brief and Prolonged Nociception in Primate STT Cells
J Neurophysiol, December 1, 2000; 84(6): 2998 - 3009.
[Abstract] [Full Text] [PDF]
F. Ango, J.-P. Pin, J. C. Tu, B. Xiao, P. F. Worley, J. Bockaert, and L. Fagni
Dendritic and Axonal Targeting of Type 5 Metabotropic Glutamate Receptor Is Regulated by Homer1 Proteins and Neuronal Excitation
J. Neurosci., December 1, 2000; 20(23): 8710 - 8716.
[Abstract] [Full Text] [PDF]
K. Toth, G. Suares, J. J. Lawrence, E. Philips-Tansey, and C. J. McBain
Differential Mechanisms of Transmission at Three Types of Mossy Fiber Synapse
J. Neurosci., November 15, 2000; 20(22): 8279 - 8289.
[Abstract] [Full Text] [PDF]
C. Normann, D. Peckys, C. H. Schulze, J. Walden, P. Jonas, and J. Bischofberger
Associative Long-Term Depression in the Hippocampus Is Dependent on Postsynaptic N-Type Ca2+ Channels
J. Neurosci., November 15, 2000; 20(22): 8290 - 8297.
[Abstract] [Full Text] [PDF]
J. L. Hardison, M. M. Okazaki, and J. V. Nadler
Modest Increase in Extracellular Potassium Unmasks Effect of Recurrent Mossy Fiber Growth
J Neurophysiol, November 1, 2000; 84(5): 2380 - 2389.
[Abstract] [Full Text] [PDF]
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