 |
 Previous Article | Next Article 
Volume 17, Number 21,
Issue of November 1, 1997
pp. 8083-8092
Copyright ©1997 Society for Neuroscience
Parapinopsin, a Novel Catfish Opsin Localized to the Parapineal
Organ, Defines a New Gene Family
Received June 4, 1997; accepted Aug. 8, 1997.
Seth Blackshaw and
Solomon H. Snyder
Johns Hopkins University School of Medicine, Departments of
Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry,
Baltimore, Maryland 21205
Multiple sites of extraretinal photoreception are present in
vertebrates, but the molecular basis of extraretinal phototransduction is poorly understood. This study reports the cloning of the first opsin
specifically expressed in the directly photosensitive pineal and
parapineal of cold-blooded vertebrates. This opsin, identified in
channel catfish and termed parapinopsin, defines a new gene family of
vertebrate photopigments and is expressed in a majority of
parapinealocytes and a subset of pineal photoreceptor cells. Parapinopsin shows a caudal-rostral gradient of expression within the
pineal organ. This study also reports the cloning of partial cDNAs
encoding the channel catfish orthologues of rhodopsin and the red cone
pigment the full complement of retinal opsins in the species.
In situ hybridization studies using probes derived from
these retinal opsins, together with parapinopsin, reveal no expression
of retinal opsins in pineal and parapineal organ and no expression of
any opsin tested in the "deep brain," iris, or dermal melanophores.
These data imply that phototransduction in these sites of extraretinal
photoreception must be mediated by novel opsins.
Key words:
pineal;
parapineal;
parapinopsin;
opsin;
deep brain;
iris;
skin;
taste bud;
extraretinal;
in situ
hybridization
This article has been cited by other articles:
|
|
|
|
 
S. N. Peirson, S. Halford, and R. G. Foster
The evolution of irradiance detection: melanopsin and the non-visual opsins
Phil Trans R Soc B,
October 12, 2009;
364(1531):
2849 - 2865.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Shichida and T. Matsuyama
Evolution of opsins and phototransduction
Phil Trans R Soc B,
October 12, 2009;
364(1531):
2881 - 2895.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tsukamoto, D. L. Farrens, M. Koyanagi, and A. Terakita
The Magnitude of the Light-induced Conformational Change in Different Rhodopsins Correlates with Their Ability to Activate G Proteins
J. Biol. Chem.,
July 31, 2009;
284(31):
20676 - 20683.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Takechi, S. Seno, and S. Kawamura
Identification of cis-Acting Elements Repressing Blue Opsin Expression in Zebrafish UV Cones and Pineal Cells
J. Biol. Chem.,
November 14, 2008;
283(46):
31625 - 31632.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. D. Snelson, K. Santhakumar, M. E. Halpern, and J. T. Gamse
Tbx2b is required for the development of the parapineal organ
Development,
May 1, 2008;
135(9):
1693 - 1702.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Griffin, M. Costigan, G. J. Brenner, C. Him Eddie Ma, J. Scholz, A. Moss, A. J. Allchorne, G. L. Stahl, and C. J. Woolf
Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity
J. Neurosci.,
August 8, 2007;
27(32):
8699 - 8708.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-Y. Su, D.-G. Luo, A. Terakita, Y. Shichida, H.-W. Liao, M. A. Kazmi, T. P. Sakmar, and K.-W. Yau
Parietal-eye phototransduction components and their potential evolutionary implications.
Science,
March 17, 2006;
311(5767):
1617 - 1621.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. C. Klein
The 2004 Aschoff/Pittendrigh Lecture: Theory of the Origin of the Pineal Gland-- A Tale of Conflict and Resolution
J Biol Rhythms,
August 1, 2004;
19(4):
264 - 279.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. K. Bowmaker and H.-J. Wagner
Pineal organs of deep-sea fish: photopigments and structure
J. Exp. Biol.,
June 15, 2004;
207(14):
2379 - 2387.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Koyanagi, E. Kawano, Y. Kinugawa, T. Oishi, Y. Shichida, S. Tamotsu, and A. Terakita
Bistable UV pigment in the lamprey pineal
PNAS,
April 27, 2004;
101(17):
6687 - 6691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Bailey and V. M. Cassone
Opsin Photoisomerases in the Chick Retina and Pineal Gland: Characterization, Localization, and Circadian Regulation
Invest. Ophthalmol. Vis. Sci.,
March 1, 2004;
45(3):
769 - 775.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. E. Knox, E. Salcedo, K. Mathiesz, J. Schaefer, W.-H. Chou, L. V. Chadwell, W. C. Smith, S. G. Britt, and R. B. Barlow
Heterologous Expression of Limulus Rhodopsin
J. Biol. Chem.,
October 17, 2003;
278(42):
40493 - 40502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. D. Rollag, D. M. Berson, and I. Provencio
Melanopsin, Ganglion-Cell Photoreceptors, and Mammalian Photoentrainment
J Biol Rhythms,
June 1, 2003;
18(3):
227 - 234.
[Abstract]
[PDF]
|
|
|
|
|
|
|
C. M. Constance, C. B. Green, H. Tei, and G. D. Block
Bulla gouldiana period exhibits unique regulation at the mrnA and Protein Levels
J Biol Rhythms,
October 1, 2002;
17(5):
413 - 427.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Forsell, P. Ekstrom, I. N. Flamarique, and B. Holmqvist
Expression of pineal ultraviolet- and green-like opsins in the pineal organ and retina of teleosts
J. Exp. Biol.,
March 9, 2002;
204(14):
2517 - 2525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Cowan, J. Thai, S. Krajewski, J. C. Reed, D. W. Nicholson, S. H. Kaufmann, and A. J. Roskams
Caspases 3 and 9 Send a Pro-Apoptotic Signal from Synapse to Cell Body in Olfactory Receptor Neurons
J. Neurosci.,
September 15, 2001;
21(18):
7099 - 7109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Kojima, H. Mano, and Y. Fukada
Vertebrate Ancient-Long Opsin: A Green-Sensitive Photoreceptive Molecule Present in Zebrafish Deep Brain and Retinal Horizontal Cells
J. Neurosci.,
April 15, 2000;
20(8):
2845 - 2851.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Philp, J. Garcia-Fernandez, B. Soni, R. Lucas, J Bellingham, and R. Foster
Vertebrate ancient (VA) opsin and extraretinal photoreception in the Atlantic salmon (Salmo salar)
J. Exp. Biol.,
January 6, 2000;
203(12):
1925 - 1936.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Kawamura, N. S. Blow, and S. Yokoyama
Genetic Analyses of Visual Pigments of the Pigeon (Columba livia)
Genetics,
December 1, 1999;
153(4):
1839 - 1850.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Blackshaw and S. H. Snyder
Encephalopsin: A Novel Mammalian Extraretinal Opsin Discretely Localized in the Brain
J. Neurosci.,
May 15, 1999;
19(10):
3681 - 3690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Max, A. Surya, J. S. Takahashi, R. F. Margolskee, and B. E. Knox
Light-dependent Activation of Rod Transducin by Pineal Opsin
J. Biol. Chem.,
October 9, 1998;
273(41):
26820 - 26826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Blackshaw and S. H. Snyder
Developmental Expression Pattern of Phototransduction Components in Mammalian Pineal Implies a Light-Sensing Function
J. Neurosci.,
November 1, 1997;
17(21):
8074 - 8082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. E. Demas, L. J. Kriegsfeld, S. Blackshaw, P. Huang, S. C. Gammie, R. J. Nelson, and S. H. Snyder
Elimination of Aggressive Behavior in Male Mice Lacking Endothelial Nitric Oxide Synthase
J. Neurosci.,
October 1, 1999;
19(19):
RC30 - RC30.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
