 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
Volume 17, Number 21, Issue of November 1, 1997 pp. 8169-8177
Copyright ©1997 Society for NeuroscienceInhibition of Synaptic Transmission by Neuropeptide Y in Rat Hippocampal Area CA1: Modulation of Presynaptic Ca2+ Entry
Received May 9, 1997; revised Aug. 11, 1997; accepted Aug. 15, 1997.
Jing Qian1, William F. Colmers2, and Peter Saggau1 1 Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, and 2 Department of Pharmacology, University of Alberta, Edmonton, Canada T6G 2H7
Neuropeptide Y (NPY) agonists inhibit glutamate release by a presynaptic action at the CA3-CA1 synapse of rat hippocampus. We have examined the relationship between [Capre]t via presynaptic, voltage-dependent calcium channels (VDCCs), measured optically by using the fluorescent calcium indicator fura-2, and transmitter release, measured electrophysiologically. Activation of presynaptic NPY Y2 receptors reduced [Capre]t and thereby inhibited synaptic transmission. Multiple calcium channels are involved in synaptic transmission at this synapse. Activation of Y2 receptors inhibits N-type, P/Q-type, and unidentified presynaptic VDCCs. The inhibition of each of these calcium channel types contributes to the reduction of [Capre]t by Y2 receptors. Activation of adenosine receptors fully occluded the inhibition of presynaptic calcium influx by Y2 receptors but not the inhibition by GABAB receptors, suggesting a convergent action for Y2 and adenosine receptors, probably by coupling to the same G-protein.
Key words: hippocampus; presynaptic calcium; synaptic transmission; neuropeptide Y; Y2 receptor; fura-2
This article has been cited by other articles:
V. A. Ledoux, T. Smejkalova, R. M. May, B. M. Cooke, and C. S. Woolley
Estradiol Facilitates the Release of Neuropeptide Y to Suppress Hippocampus-Dependent Seizures
J. Neurosci., February 4, 2009; 29(5): 1457 - 1468.
[Abstract] [Full Text] [PDF]
A. R. Gutman, Y. Yang, K. J. Ressler, and M. Davis
The Role of Neuropeptide Y in the Expression and Extinction of Fear-Potentiated Startle
J. Neurosci., November 26, 2008; 28(48): 12682 - 12690.
[Abstract] [Full Text] [PDF]
J. Baufreton and M. D. Bevan
D2-like dopamine receptor-mediated modulation of activity-dependent plasticity at GABAergic synapses in the subthalamic nucleus
J. Physiol., April 15, 2008; 586(8): 2121 - 2142.
[Abstract] [Full Text] [PDF]
D. Kroeger and F. Amzica
Hypersensitivity of the Anesthesia-Induced Comatose Brain
J. Neurosci., September 26, 2007; 27(39): 10597 - 10607.
[Abstract] [Full Text] [PDF]
J. Qian and J. L. Noebels
Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse.
J. Neurosci., May 31, 2006; 26(22): 6089 - 6095.
[Abstract] [Full Text] [PDF]
B. Tu, O. Timofeeva, Y. Jiao, and J. V. Nadler
Spontaneous Release of Neuropeptide Y Tonically Inhibits Recurrent Mossy Fiber Synaptic Transmission in Epileptic Brain
J. Neurosci., February 16, 2005; 25(7): 1718 - 1729.
[Abstract] [Full Text] [PDF]
T. D. Moran, W. F. Colmers, and P. A. Smith
Opioid-Like Actions of Neuropeptide Y in Rat Substantia Gelatinosa: Y1 Suppression of Inhibition and Y2 Suppression of Excitation
J Neurophysiol, December 1, 2004; 92(6): 3266 - 3275.
[Abstract] [Full Text] [PDF]
A. Scheuber, R. Miles, and J. C. Poncer
Presynaptic Cav2.1 and Cav2.2 Differentially Influence Release Dynamics at Hippocampal Excitatory Synapses
J. Neurosci., November 17, 2004; 24(46): 10402 - 10409.
[Abstract] [Full Text] [PDF]
T. M. Hoogland and P. Saggau
Facilitation of L-Type Ca2+ Channels in Dendritic Spines by Activation of {beta}2 Adrenergic Receptors
J. Neurosci., September 29, 2004; 24(39): 8416 - 8427.
[Abstract] [Full Text] [PDF]
R. Bertram, J. Swanson, M. Yousef, Z.-P. Feng, and G. W. Zamponi
A Minimal Model for G Protein-Mediated Synaptic Facilitation and Depression
J Neurophysiol, September 1, 2003; 90(3): 1643 - 1653.
[Abstract] [Full Text] [PDF]
A. Bacci, J. R. Huguenard, and D. A. Prince
Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons
PNAS, December 24, 2002; 99(26): 17125 - 17130.
[Abstract] [Full Text] [PDF]
A. R. Pentney, S. C. Baraban, and W. F. Colmers
NPY Sensitivity and Postsynaptic Properties of Heterotopic Neurons in the MAM Model of Malformation-Associated Epilepsy
J Neurophysiol, November 1, 2002; 88(5): 2745 - 2754.
[Abstract] [Full Text] [PDF]
G. C. Faas, H. Adwanikar, R. W. Gereau IV, and P. Saggau
Modulation of Presynaptic Calcium Transients by Metabotropic Glutamate Receptor Activation: A Differential Role in Acute Depression of Synaptic Transmission and Long-Term Depression
J. Neurosci., August 15, 2002; 22(16): 6885 - 6890.
[Abstract] [Full Text] [PDF]
Z. Xiang, J. R. Huguenard, and D. A. Prince
Synaptic Inhibition of Pyramidal Cells Evoked by Different Interneuronal Subtypes in Layer V of Rat Visual Cortex
J Neurophysiol, August 1, 2002; 88(2): 740 - 750.
[Abstract] [Full Text] [PDF]
R. Bejar, R. Yasuda, H. Krugers, K. Hood, and M. Mayford
Transgenic Calmodulin-Dependent Protein Kinase II Activation: Dose-Dependent Effects on Synaptic Plasticity, Learning, and Memory
J. Neurosci., July 1, 2002; 22(13): 5719 - 5726.
[Abstract] [Full Text] [PDF]
R. Bertram, M. I. Arnot, and G. W. Zamponi
Role for G Protein Gbeta gamma Isoform Specificity in Synaptic Signal Processing: A Computational Study
J Neurophysiol, May 1, 2002; 87(5): 2612 - 2623.
[Abstract] [Full Text] [PDF]
A. J. Straiker, C. R. Borden, and J. M. Sullivan
G-Protein alpha Subunit Isoforms Couple Differentially to Receptors that Mediate Presynaptic Inhibition at Rat Hippocampal Synapses
J. Neurosci., April 1, 2002; 22(7): 2460 - 2468.
[Abstract] [Full Text] [PDF]
H. Guo, P. A. Castro, R. D. Palmiter, and S. C. Baraban
Y5 Receptors Mediate Neuropeptide Y Actions at Excitatory Synapses in Area CA3 of the Mouse Hippocampus
J Neurophysiol, January 1, 2002; 87(1): 558 - 566.
[Abstract] [Full Text] [PDF]
O. Yermolaieva, J. Chen, P. R. Couceyro, and T. Hoshi
Cocaine- and Amphetamine-Regulated Transcript Peptide Modulation of Voltage-Gated Ca2+ Signaling in Hippocampal Neurons
J. Neurosci., October 1, 2001; 21(19): 7474 - 7480.
[Abstract] [Full Text] [PDF]
J. Qian and J. L. Noebels
Presynaptic Ca2+ Channels and Neurotransmitter Release at the Terminal of a Mouse Cortical Neuron
J. Neurosci., June 1, 2001; 21(11): 3721 - 3728.
[Abstract] [Full Text] [PDF]
R. D. King, M. C. Wiest, and P. R. Montague
Extracellular Calcium Depletion as a Mechanism of Short-Term Synaptic Depression
J Neurophysiol, May 1, 2001; 85(5): 1952 - 1959.
[Abstract] [Full Text] [PDF]
M Hirasawa, S B Kombian, and Q J Pittman
Oxytocin retrogradely inhibits evoked, but not miniature, EPSCs in the rat supraoptic nucleus: role of N- and P/Q-type calcium channels
J. Physiol., May 1, 2001; 532(3): 595 - 607.
[Abstract] [Full Text] [PDF]
M. Massimini and F. Amzica
Extracellular Calcium Fluctuations and Intracellular Potentials in the Cortex During the Slow Sleep Oscillation
J Neurophysiol, March 1, 2001; 85(3): 1346 - 1350.
[Abstract] [Full Text] [PDF]
Q.-Q. Sun, J. R Huguenard, and D. A Prince
Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons
J. Physiol., February 15, 2001; 531(1): 67 - 79.
[Abstract] [Full Text] [PDF]
Q.-Q. Sun, G. Akk, J. R Huguenard, and D. A Prince
Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons
J. Physiol., February 15, 2001; 531(1): 81 - 94.
[Abstract] [Full Text] [PDF]
E. Terasawa and D. L. Fernandez
Neurobiological Mechanisms of the Onset of Puberty in Primates
Endocr. Rev., February 1, 2001; 22(1): 111 - 151.
[Abstract] [Full Text]
A. Thorsell, M. Michalkiewicz, Y. Dumont, R. Quirion, L. Caberlotto, R. Rimondini, A. A. Mathé, and M. Heilig
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
PNAS, October 26, 2000; (2000) 220232997.
[Abstract] [Full Text]
M. Mizuno, M. Gearing, and E. Terasawa
The Role of Neuropeptide Y in the Progesterone-Induced Luteinizing Hormone-Releasing Hormone Surge in Vivo in Ovariectomized Female Rhesus Monkeys
Endocrinology, May 1, 2000; 141(5): 1772 - 1779.
[Abstract] [Full Text] [PDF]
M. C. Wiest, D. M. Eagleman, R. D. King, and P. R. Montague
Dendritic Spikes and Their Influence on Extracellular Calcium Signaling
J Neurophysiol, March 1, 2000; 83(3): 1329 - 1337.
[Abstract] [Full Text] [PDF]
M. W. Y. Ho, A. G. Beck-Sickinger, and W. F. Colmers
Neuropeptide Y5 Receptors Reduce Synaptic Excitation in Proximal Subiculum, But Not Epileptiform Activity in Rat Hippocampal Slices
J Neurophysiol, February 1, 2000; 83(2): 723 - 734.
[Abstract] [Full Text] [PDF]
J. Qian and J. L. Noebels
Presynaptic Ca2+ Influx at a Mouse Central Synapse with Ca2+ Channel Subunit Mutations
J. Neurosci., January 1, 2000; 20(1): 163 - 170.
[Abstract] [Full Text] [PDF]
L.-G. Wu, R. E. Westenbroek, J. G. G. Borst, W. A. Catterall, and B. Sakmann
Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses
J. Neurosci., January 15, 1999; 19(2): 726 - 736.
[Abstract] [Full Text] [PDF]
J. Qian and P. Saggau
Modulation of Transmitter Release by Action Potential Duration at the Hippocampal CA3-CA1 Synapse
J Neurophysiol, January 1, 1999; 81(1): 288 - 298.
[Abstract] [Full Text] [PDF]
D. M. Egelman and P. R. Montague
Computational Properties of Peri-Dendritic Calcium Fluctuations
J. Neurosci., November 1, 1998; 18(21): 8580 - 8589.
[Abstract] [Full Text] [PDF]
V. P. Bindokas, C. C. Lee, W. F. Colmers, and R. J. Miller
Changes in Mitochondrial Function Resulting from Synaptic Activity in the Rat Hippocampal Slice
J. Neurosci., June 15, 1998; 18(12): 4570 - 4587.
[Abstract] [Full Text] [PDF]
A. Thorsell, M. Michalkiewicz, Y. Dumont, R. Quirion, L. Caberlotto, R. Rimondini, A. A. Mathe, and M. Heilig
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression
PNAS, November 7, 2000; 97(23): 12852 - 12857.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|