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Volume 17, Number 21, Issue of November 1, 1997 pp. 8259-8269
Copyright ©1997 Society for Neuroscience

OSM-9, A Novel Protein with Structural Similarity to Channels, Is Required for Olfaction, Mechanosensation, and Olfactory Adaptation in Caenorhabditis elegans

Received June 27, 1997; accepted Aug. 19, 1997.

Heather A. Colbert, Tracy L. Smith, and Cornelia I. Bargmann

Howard Hughes Medical Institute, Programs in Developmental Biology, Neuroscience, and Genetics, Department of Anatomy, The University of California, San Francisco, California 94143-0452

Although cyclic nucleotide-gated channels mediate sensory transduction in olfaction and vision, other forms of sensory transduction are independent of these channels. Caenorhabditis elegans cyclic nucleotide-gated channel mutants respond normally to some olfactory stimuli and to osmotic stimuli, suggesting that these chemosensory responses use an alternative sensory transduction pathway. One gene that may act in this pathway is osm-9, which is required for each of these responses as well as a mechanosensory response to nose touch. osm-9 encodes a protein with ankyrin repeats and multiple predicted transmembrane domains that has limited similarity to the Drosophila phototransduction channels transient receptor potential (TRP) and TRP-like (TRPL). The sequence of OSM-9 and other TRP-like genes reveals a previously unsuspected diversity of mammalian and invertebrate genes in this family. osm-9 is required for the activity of the predicted G-protein-coupled odorant receptor ODR-10, which acts in the AWA olfactory neurons; its similarity to other G-protein-regulated transduction channels suggests that OSM-9 is involved in AWA signaling. osm-9:: GFP fusion genes are expressed in a subset of chemosensory, mechanosensory, and osmosensory neurons. osm-9 also affects olfactory adaptation within neurons that require the cyclic nucleotide-gated channel for olfaction; in these neurons, the gene has a regulatory function and not a primary role in sensory transduction.

Key words: olfaction; C. elegans; mechanosensation; sensory transduction; signaling pathways; olfactory adaptation; TRP channels




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TRP2: A candidate transduction channel for mammalian pheromone sensory signaling
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U. Wissenbach, B. A. Niemeyer, T. Fixemer, A. Schneidewind, C. Trost, A. Cavalie, K. Reus, E. Meese, H. Bonkhoff, and V. Flockerzi
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Cellular and Subcellular Localization, N-terminal Acylation, and Calcium Binding of Caenorhabditis elegans Protein Phosphatase with EF-hands
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J.-B. Peng, X.-Z. Chen, U. V. Berger, P. M. Vassilev, E. M. Brown, and M. A. Hediger
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