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Volume 17, Number 21,
Issue of November 1, 1997
pp. 8259-8269
Copyright ©1997 Society for Neuroscience
OSM-9, A Novel Protein with Structural Similarity to Channels, Is
Required for Olfaction, Mechanosensation, and Olfactory Adaptation in
Caenorhabditis elegans
Received June 27, 1997; accepted Aug. 19, 1997.
Heather A. Colbert,
Tracy L. Smith, and
Cornelia I. Bargmann
Howard Hughes Medical Institute, Programs in Developmental Biology,
Neuroscience, and Genetics, Department of Anatomy, The University of
California, San Francisco, California 94143-0452
Although cyclic nucleotide-gated channels mediate sensory
transduction in olfaction and vision, other forms of sensory
transduction are independent of these channels. Caenorhabditis
elegans cyclic nucleotide-gated channel mutants respond
normally to some olfactory stimuli and to osmotic stimuli, suggesting
that these chemosensory responses use an alternative sensory
transduction pathway. One gene that may act in this pathway is
osm-9, which is required for each of these responses as
well as a mechanosensory response to nose touch. osm-9
encodes a protein with ankyrin repeats and multiple predicted
transmembrane domains that has limited similarity to the
Drosophila phototransduction channels transient receptor potential (TRP) and TRP-like (TRPL). The sequence of OSM-9 and other
TRP-like genes reveals a previously unsuspected diversity of mammalian
and invertebrate genes in this family. osm-9 is required for the activity of the predicted G-protein-coupled odorant receptor ODR-10, which acts in the AWA olfactory neurons; its similarity to
other G-protein-regulated transduction channels suggests that OSM-9 is
involved in AWA signaling. osm-9:: GFP fusion
genes are expressed in a subset of chemosensory, mechanosensory, and
osmosensory neurons. osm-9 also affects olfactory
adaptation within neurons that require the cyclic nucleotide-gated
channel for olfaction; in these neurons, the gene has a regulatory
function and not a primary role in sensory transduction.
Key words:
olfaction;
C. elegans;
mechanosensation;
sensory transduction;
signaling pathways;
olfactory adaptation;
TRP
channels
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|
|
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|
|
|
|
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|
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|
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|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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[Full Text]
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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[PDF]
|
|
|
|
|
|
|
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117(12):
2449 - 2460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Alessandri-Haber, O. A. Dina, J. J. Yeh, C. A. Parada, D. B. Reichling, and J. D. Levine
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[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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167(1):
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[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Drew, D. K. Rohrer, M. P. Price, K. E. Blaver, D. A. Cockayne, P. Cesare, and J. N. Wood
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556(3):
691 - 710.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Zhang, I. Sokolchik, G. Blanco, and J. Y. Sze
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131(7):
1629 - 1638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sukharev and D. P. Corey
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February 10, 2004;
2004(219):
re4 - re4.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Nilius, J. Vriens, J. Prenen, G. Droogmans, and T. Voets
TRPV4 calcium entry channel: a paradigm for gating diversity
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286(2):
C195 - C205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Liu and E. R. Liman
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December 9, 2003;
100(25):
15160 - 15165.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Liedtke, D. M. Tobin, C. I. Bargmann, and J. M. Friedman
Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans
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100(suppl_2):
14531 - 14536.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Yu, R. F. Pretot, T. R. Burglin, and P. W. Sternberg
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November 1, 2003;
130(21):
5217 - 5227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Gao, L. Wu, and R. G. O'Neil
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J. Biol. Chem.,
July 11, 2003;
278(29):
27129 - 27137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sidi, R. W. Friedrich, and T. Nicolson
NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction
Science,
July 4, 2003;
301(5629):
96 - 99.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mizuno, N. Matsumoto, M. Imai, and M. Suzuki
Impaired osmotic sensation in mice lacking TRPV4
Am J Physiol Cell Physiol,
July 1, 2003;
285(1):
C96 - C101.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Suzuki, A. Mizuno, K. Kodaira, and M. Imai
Impaired Pressure Sensation in Mice Lacking TRPV4
J. Biol. Chem.,
June 13, 2003;
278(25):
22664 - 22668.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-L. Zhou, A. F. Batiza, S. H. Loukin, C. P. Palmer, C. Kung, and Y. Saimi
The transient receptor potential channel on the yeast vacuole is mechanosensitive
PNAS,
June 10, 2003;
100(12):
7105 - 7110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Strange
From Genes to Integrative Physiology: Ion Channel and Transporter Biology in Caenorhabditis elegans
Physiol Rev,
April 1, 2003;
83(2):
377 - 415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Xu, H. Zhao, W. Tian, K. Yoshida, J.-B. Roullet, and D. M. Cohen
Regulation of a Transient Receptor Potential (TRP) Channel by Tyrosine Phosphorylation. SRC FAMILY KINASE-DEPENDENT TYROSINE PHOSPHORYLATION OF TRPV4 ON TYR-253 MEDIATES ITS RESPONSE TO HYPOTONIC STRESS
J. Biol. Chem.,
March 21, 2003;
278(13):
11520 - 11527.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. M. Nolan, T. R. Sarafi-Reinach, J. G. Horne, A. M. Saffer, and P. Sengupta
The DAF-7 TGF-beta signaling pathway regulates chemosensory receptor gene expression in C. elegans
Genes & Dev.,
December 1, 2002;
16(23):
3061 - 3073.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Watanabe, J. Vriens, S. H. Suh, C. D. Benham, G. Droogmans, and B. Nilius
Heat-evoked Activation of TRPV4 Channels in a HEK293 Cell Expression System and in Native Mouse Aorta Endothelial Cells
J. Biol. Chem.,
November 27, 2002;
277(49):
47044 - 47051.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Di Palma, I. A. Belyantseva, H. J. Kim, T. F. Vogt, B. Kachar, and K. Noben-Trauth
From the Cover: Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice
PNAS,
November 12, 2002;
99(23):
14994 - 14999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. G. Leypold, C. R. Yu, T. Leinders-Zufall, M. M. Kim, F. Zufall, and R. Axel
Altered sexual and social behaviors in trp2 mutant mice
PNAS,
April 30, 2002;
99(9):
6376 - 6381.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Watanabe, J. B. Davis, D. Smart, J. C. Jerman, G. D. Smith, P. Hayes, J. Vriens, W. Cairns, U. Wissenbach, J. Prenen, et al.
Activation of TRPV4 Channels (hVRL-2/mTRP12) by Phorbol Derivatives
J. Biol. Chem.,
April 12, 2002;
277(16):
13569 - 13577.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Minke and B. Cook
TRP Channel Proteins and Signal Transduction
Physiol Rev,
April 1, 2002;
82(2):
429 - 472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Cinelli, D. Wang, P. Chen, W. Liu, and M. Halpern
Calcium Transients in the Garter Snake Vomeronasal Organ
J Neurophysiol,
March 1, 2002;
87(3):
1449 - 1472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X.-Z. S. Xu, F. Moebius, D. L. Gill, and C. Montell
Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform
PNAS,
September 4, 2001;
(2001)
191360198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Muller, J. G. J. Hoenderop, C. H. van Os, and R. J. M. Bindels
The epithelial calcium channel, ECaC1: molecular details of a novel player in renal calcium handling
Nephrol. Dial. Transplant.,
July 1, 2001;
16(7):
1329 - 1335.
[Full Text]
| |
