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Previous Article | Next Article
Volume 17, Number 21, Issue of November 1, 1997 pp. 8300-8312
Copyright ©1997 Society for NeuroscienceExpression of Neural RNA-Binding Proteins in the Postnatal CNS: Implications of Their Roles in Neuronal and Glial Cell Development
Received May 14, 1997; revised Aug. 18, 1997; accepted Aug. 19, 1997.
Shin-ichi Sakakibara1 and Hideyuki Okano1, 2 1 Department of Neuroanatomy, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565, Japan, and 2 Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Shinagawa, Tokyo 140, Japan
There is an increasing interest in the role of RNA-binding proteins during neural development. Mouse-Musashi-1 (m-Msi-1) is a mouse neural RNA-binding protein with sequence similarity to Drosophila musashi (d-msi), which is essential for neural development. m-Msi-1 is highly enriched in neural precursor cells that are capable of generating both neurons and glia during embryonic CNS development. The present study characterized m-Msi-1-expressing cells in the postnatal and adult CNS. Postnatally, m-Msi-1 was expressed in proliferative neuronal precursors in the external granule cell layer of the cerebellum and in the anterior corner of the subventricular zone of the lateral ventricles. In gliogenesis, the persistent expression of m-Msi-1 was observed in cells of the astrocyte lineage ranging from proliferative glial precursors in the subventricular zone (SVZ) to differentiated astrocytes in the parenchyma. In addition, we showed that m-Msi-1 was still expressed in proliferating cells in the adult SVZ, which may contain neural precursor or stem cells. Another neural RNA-binding protein Hu (the mammalian homolog of a Drosophila neuronal RNA-binding protein Elav) was present in postmitotic neurons throughout the development of the CNS, and its pattern of expression was compared with that of m-Msi-1. These observations imply that these two RNA-binding proteins may be involved in the development of neurons and glia by regulating gene expression at the post-transcriptional level.
Key words: RNA-binding proteins; postnatal CNS; mouse-Musashi-1 (m-Msi-1); Hu; Drosophila musashi; neuronal and glial precursor cells; astrocyte lineage
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